We thank all of the members of the ANRS CO22 HEPATHER cohort Study Group, all the patients who participated in the HRQoL study, and all the healthcare staff involved in patient follow-up in each centre. Our thanks also to the INSERM-ANRS MIE for sponsoring, funding and supervising the ANRS CO22 HEPATHER cohort in collaboration with the French Association for the Study of the Liver (Association Française pour l’Etude du Foie: AFEF). Finally, we thank Jude Sweeney (Milan, Italy) for the English revision and copyediting of our manuscript. The ANRS/AFEF HEPATHER Study Group: Investigators Laurent Alric, Delphine Bonnet, Océane Camou (CHU Rangueil, Toulouse, France), Fabien Zoulim, Marianne Maynard, François Bailly, Bénédicte Poumaroux, Miroslava Subic (Hospices Civils de Lyon, Lyon, France), François Raffi, Eric Billaud, David Boutoille, Maeva Lefebvre, Elisabeth André-Garnier (Hôpital Hôtel-Dieu, Nantes, France), Paul Cales, Isabelle Hubert, Clémence Canivet, Françoise Lunel, Jérôme Boursier (CHU Angers, Angers, France), Tarik Asselah, Nathalie Boyer, Nathalie Giuily, Corinne Castelnau, Giovanna Scoazec (Hôpital Beaujon, Clichy, France), Stanislas Pol, Hélène Fontaine, Lucia Parlati, Emilie Rousseaud, Anaïs Vallet-Pichard, Philippe Sogni (Hôpital Cochin, Paris, France), Victor de Ledinghen, Juliette Foucher, Jean-Baptiste Hiriart, Paul Hermabessière, Marie Irlès-Depé (Hôpital Haut-Lévêque, Pessac, Bordeaux, France), Marc Bourlière, Si Nafa Si Ahmed, Valérie Oules, Rania Kibeche (Hôpital Saint Joseph, Marseille, France), Albert Tran, Rodolphe Anty, Eve Gelsi, Régine Truchi (CHU de Nice, Nice, France), Dominique Thabut, Saloua Hammeche, Joseph Moussali (Hôpital de la Pitié Salptétrière, Paris, France), Xavier Causse, Barbara De Dieuleveult, Brahim Ouarani, Damien Labarrière, Magali Jeulin (CHR La Source, Orléans, France), Nathalie Ganne, Véronique Grando-Lemaire, Pierre Nahon, Séverine Brulé, Lucie Del Pozo (Avicenne, Bobigny, France), Caroline Jezequel, Audrey Brener (CHU Rennes, Rennes, France), François Habersetzer, Thomas F. Baumert, Lawrence Serfaty, Pauline Simo-Noumbissie, Alexandre Bolle (Hôpitaux Universitaires de Strasbourg, Strasbourg, France), Jean-Pierre Bronowicki, Mouni Bensenane-Oussalah, Vincent Haghnejad, Sébastien Daude, Sarah Hadj-Rhouma (CHU de Nancy, Nancy, France), Georges-Philippe Pageaux, Dominique Larrey, Magda Meszaros (Hôpital Saint Eloi, Montpellier, France), Sophie Metivier, Christophe Bureau, Thibault Morales, Jean Marie Peron, Hélène Larrue (CHU Rangueil, Toulouse, France), Thomas Decaens, Marie-Noelle Hilleret, Charlotte Costentin, Bleuenn Brusset, Agnès Bonadona (CHU de Grenoble, Grenoble, France), Ghassan Riachi, Odile Goria, Fatima Paris, Hélène Montialoux (CHU Charles Nicolle, Rouen, France), Vincent Leroy, Giuliana Amaddeo, Anne Varaut, Mélanie Simoes, Rachida Amzal, Slim Fourati (Hôpital Henri Mondor, Créteil, France), Olivier Chazouillières, Tony Andreani, Bénédicte Angoulevant, Azeline Chevance (Hôpital Saint-Antoine, Paris, France), Jean-Charles Duclos Vallée, Audrey Coilly, Rodolphe Sobesky, Alina Pascale (Hôpital Paul Brousse, Villejuif, France), Benjamin Buchard, Armand Abergel, Maud Reymond, Chanteranne Brigitte, Léon Muti (Hôpital Estaing, Clermont-Ferrand, France), Vincent Di Martino (Hôpital Jean-Minjoz, Besançon, France), Claire Geist, Guillaume Conroy, Raphaëlle Riffault (Centre Hospitalier Régional, Metz, France), Isabelle Rosa, Camille Barrault, Laurent Costes, Anne Wampach (Centre Hospitalier Intercommunal, Créteil, France), Véronique Loustaud-Ratti, Paul Carrier, Maryline Debette-Gratien, (CHU Limoges, Limoges, France), Christine Silvain, Valentin Rolle, Valérie Roumy, Astrid Guyot d’Asnières de Salins (Hôpital de la Milétrie, Poitiers, France), Philippe Mathurin, Guillaume Lassailly, Elise Lemaitre, Valérie Canva, Sébastien Dharancy, Alexandre Louvet (CHRU Claude Huriez, Lille, France), Anne Minello, Marianne Latournerie, Thomas Mouillot Léa Lerosey, Théophile Gerster (Dijon University Hospital, Dijon, France), Dominique Roulot, Zahia Ben Abdesselam, (Hôpital Avicenne, Bobigny, France), Louis D’Alteroche, Coralie Fleurent, Charlotte Nicolas, Laure Elkrief, Anaïs Jaillais (CHU Trousseau, 37044 Tours, France), Denis Ouzan (Institut Arnault Tzank, Saint-Laurent-du-Var, France), Jérôme Gournay, Caroline Chevalier, Isabelle Archambeaud (CHU de Nantes, Nantes, France), Isabelle Portal (CHU Timone, Marseille, France), Thông Dao (Hôpital de la Côte de Nacre, Caen, France), Moana Gelu-Simeon, Marie-Josée Lafrance, Lucie Catherine (CHU de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe). Methodology and Coordinating Centre Fabrice Carrat (coordinator), Frederic Chau, Céline Dorival, Isabelle Goderel, Clovis Lusivika-Nzinga, Jonathan Bellet, Jessica Chane-Teng, Grégory Pannetier, Jérôme Nicol (Sorbonne University & INSERM U1136—IPLESP, Paris, France). Sponsor Carole Cagnot, Anaïs Boston, Laura Nailler, Guillaume Le Meut, Cécile Moins, Elise Landry (INSERM-ANRS-MIE, Paris, France), Alpha Diallo (Pharmacovigilance coordinator), Ventzislava Petrov-Sanchez (coordinator). Scientific Committee Marc Bourlière (Hôpital St Joseph, Marseille), Jérôme Boursier (CHU Angers, Angers, France), Fabrice Carrat (Scientific Coordinator, Hôpital Saint-Antoine, Paris, France), Patrizia Carrieri (INSERM U912, Marseille, France), Elisabeth Delarocque-Astagneau (Inserm UMR1181, Paris), Victor De Ledinghen (Hôpital Haut-Lévêque, Pessac, Bordeaux, France), Céline Dorival (UPMC & INSERM U1136, Paris, France), Hélène Fontaine (Hôpital Cochin, Paris, France), Slim Fourati (Hôpital Henri Mondor, Créteil, France), Chantal Housset (Inserm UMR-S938 1 IFR65, Paris), Dominique Larrey (Hôpital Saint Eloi, Montpellier, France), Pierre Nahon (Hôpital Jean Verdier, Bondy, France), Georges-Philippe Pageaux (Hôpital Saint Eloi, Montpellier, France), Ventzislava Petrov-Sanchez (ANRS, Paris, France), Stanislas Pol (Principal Investigator, Hôpital Cochin, Paris, France), Mathias Bruyand (Agence Nationale de Santé Publique, Saint Maurice, France), Linda Wittkop (ISPED-INSERM U897, Bordeaux, France), Fabien Zoulim (Hospices Civils de Lyon, Lyon, France), Jessica Zucman-Rossi (Inserm U674/1162, Paris). Cécile Brouard (Agence Nationale de Santé Publique, Saint Maurice, France), Frederic Chau, Isabelle Goderel, Clovis Lusivika-Nzinga, Jonathan Bellet, Jessica Chane-Teng, Grégory Pannetier, Jérôme Nicol (Sorbonne University & INSERM U1136—IPLESP, Paris, France). Marianne L’hennaff (ARCAT-TRT-5-CHV, France), Michèle Sizorn (SOS hépatites, France); one representative from the INSERM-ANRS-MIE Pharmacovigilance team, Paris, France (Anaïs Boston, Alpha Diallo), Carole Cagnot (INSERM-ANRS-MIE, Paris, France), one member from Inserm Transfert, Paris, France (Alice Bousselet, Mireille Caralp), and one representative from each pharmaceutical company (MSD, Gilead, Abbvie).