Document Type : original article

Authors

1 Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Childern's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 pediatric Congenital Hematologic Disorders Research Center, Research Institute for Childern's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 marjan Shakiba , Pediatric Endocrinologist, Mofid Children Hospital,Shahid Beheshti Universityof Medical Science,Iran,Tehran

4 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

10.22038/ijp.2023.56986.4603

Abstract

Background: Leukemia is one of the most common malignancies in childhood, accounting for about 40 children per million children under the age of 15 years. Regarding the improvement in life expectancy and the prolonged life of patients with acute lymphoblastic leukemia, identifying the long-term complications and effects of treatment in patients is necessary.

Methods: The present applied study is a cohort study based on the case-control method. 50 patients who had improved acute lymphoblastic leukemia were selected as case group and in a sequential manner in Mofid Children Hospital.

50 other people who had no history of ALL disease were selected as the control group. All information gathering process including patient history, physical examination, and necessary tests were done step-by-step by pediatric hematology oncology subspeciality fellow and trained personnel with full supervision of Pediatric hematologist - oncologist. Blood samples were taken at 10-cc of fasting blood. Blood samples after centrifugation and storage at 20 ° C were used to measure serum fasting blood glucose, triglyceride (Slovak based on serum lipid profile), and insulin levels. All demographic information, BMI, clinical symptoms, laboratory tests, and treatments were recorded in both forms.

Finding: Based on the results of this study, the incidence of obesity was significantly higher in patients with ALL than other people. The risk of obesity in ALL patients is approximately

9 times higher than other people. In this study 6 (12%) patients in cases and 4 (%8) patients in controls had metabolic syndrome. The results showed that there was no statistically significant difference between the groups in the incidence of metabolic syndrome, insulin resistance, and visceral obesity.

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