Ransohoff RM (2016) How neuroinflammation contributes to neurodegeneration. Science 353(6301):777–783. https://doi.org/10.1126/science.aag2590

Article  CAS  PubMed  Google Scholar 

Hou Y, Dan X, Babbar M et al (2019) Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol 15(10):565–581. https://doi.org/10.1038/s41582-019-0244-7

Article  PubMed  Google Scholar 

Droge W, Schipper HM (2007) Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell 6(3):361–370. https://doi.org/10.1111/j.1474-9726.2007.00294.x

Article  CAS  PubMed  Google Scholar 

Gong Z, Huang J, Xu B et al (2019) Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice. J Neuroinflammation 16(1):62. https://doi.org/10.1186/s12974-019-1450-3

Article  PubMed  PubMed Central  Google Scholar 

Aguado J, d’Adda di Fagagna F, Wolvetang E (2020) Telomere transcription in ageing. Ageing Res Rev. https://doi.org/10.1016/j.arr.2020.101115

Article  PubMed  Google Scholar 

Sahin E, DePinho RA (2012) Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol 13(6):397–404. https://doi.org/10.1038/nrm3352

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lv X, Wang X, Wang Y et al (2019) Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism. Aging (Albany NY). 11(22):10356–10373. https://doi.org/10.18632/aging.102461

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ionescu-Tucker A, Cotman CW (2021) Emerging roles of oxidative stress in brain aging and Alzheimer’s disease. Neurobiol Aging 107:86–95. https://doi.org/10.1016/j.neurobiolaging.2021.07.014

Article  CAS  PubMed  Google Scholar 

Bai R, Guo J, Ye XY et al (2022) Oxidative stress: the core pathogenesis and mechanism of Alzheimer’s disease. Ageing Res Rev 77:101619. https://doi.org/10.1016/j.arr.2022.101619

Article  CAS  PubMed  Google Scholar 

Birben E, Sahiner UM, Sackesen C et al (2012) Oxidative stress and antioxidant defense. World Allergy Organ J 5(1):9–19. https://doi.org/10.1097/WOX.0b013e3182439613

Article  CAS  PubMed  PubMed Central  Google Scholar 

Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci 20(3):148–160. https://doi.org/10.1038/s41583-019-0132-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ao GZ, Chu XJ, Ji YY et al (2014) Antioxidant properties and PC12 cell protective effects of a novel curcumin analogue (2E,6E)-2,6-bis(3,5- dimethoxybenzylidene)cyclohexanone (MCH). Int J Mol Sci 15(3):3970–3988. https://doi.org/10.3390/ijms15033970

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao X, Liu J, Hu J et al (2008) Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca(2+) antagonism and antioxidant mechanisms. Eur J Pharmacol 591(1–3):21–27. https://doi.org/10.1016/j.ejphar.2008.06.045

Article  CAS  PubMed  Google Scholar 

Tower J (2015) Programmed cell death in aging. Ageing Res Rev 23(Pt A):90–100. https://doi.org/10.1016/j.arr.2015.04.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burgos-Barragan G, Wit N, Meiser J et al (2017) Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism. Nature 548(7669):549–554. https://doi.org/10.1038/nature23481

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caffrey A, McNulty H, Irwin RE et al (2019) Maternal folate nutrition and offspring health: evidence and current controversies. Proc Nutr Soc 78(2):208–220. https://doi.org/10.1017/S0029665118002689

Article  PubMed  Google Scholar 

Gallego-Lopez MDC, Ojeda ML, Romero-Herrera I et al (2022) Folic acid homeostasis and its pathways related to hepatic oxidation in adolescent rats exposed to binge drinking. Antioxidants (Basel). https://doi.org/10.3390/antiox11020362

Article  PubMed  PubMed Central  Google Scholar 

Mattson MP (2003) Will caloric restriction and folate protect against AD and PD? Neurology 60(4):690–695. https://doi.org/10.1212/01.wnl.0000042785.02850.11

Article  CAS  PubMed  Google Scholar 

Li W, Ma Y, Li Z et al (2019) Folic acid decreases astrocyte apoptosis by preventing oxidative stress-induced telomere attrition. Int J Mol Sci. https://doi.org/10.3390/ijms21010062

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Li W, Zhou D et al (2022) Alleviating oxidative damage-induced telomere attrition: a potential mechanism for inhibition by folic acid of apoptosis in neural stem cells. Mol Neurobiol 59(1):590–602. https://doi.org/10.1007/s12035-021-02623-3

Article  CAS  PubMed  Google Scholar 

Ghasemi A, Jeddi S, Kashfi K (2021) The laboratory rat: Age and body weight matter. EXCLI J 20:1431–1445. https://doi.org/10.17179/excli2021-4072

Article  PubMed  PubMed Central  Google Scholar 

Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123(11):1939–1951. https://doi.org/10.1093/jn/123.11.1939

Article  CAS  PubMed  Google Scholar 

Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22(3):659–661. https://doi.org/10.1096/fj.07-9574LSF

Article  CAS  PubMed  Google Scholar 

Lin H, Chen H, Qi B et al (2021) Brain-derived extracellular vesicles mediated coagulopathy, inflammation and apoptosis after sepsis. Thromb Res 207:85–95. https://doi.org/10.1016/j.thromres.2021.09.014

Article  CAS  PubMed  Google Scholar 

Moore CL, Savenka AV, Basnakian AG (2021) TUNEL assay: a powerful tool for kidney injury evaluation. Int J Mol Sci. https://doi.org/10.3390/ijms22010412

Article  PubMed  PubMed Central  Google Scholar 

Sharifi-Sanjani M, Meeker AK, Mourkioti F (2017) Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH. Nat Protoc 12(9):1855–1870. https://doi.org/10.1038/nprot.2017.082

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barkovskaya MS, Bogomolov AG, Knauer NY et al (2017) Development of software and modification of Q-FISH protocol for estimation of individual telomere length in immunopathology. J Bioinform Comput Biol 15(2):1650041. https://doi.org/10.1142/S0219720016500414

Article  CAS  PubMed  Google Scholar 

Mourkioti F, Kustan J, Kraft P et al (2013) Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nat Cell Biol 15(8):895–904. https://doi.org/10.1038/ncb2790

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shoeb M, Kodali VK, Farris BY et al (2017) Oxidative stress, dna methylation, and telomere length changes in peripheral blood mononuclear cells after pulmonary exposure to metal-rich welding nanoparticles. NanoImpact 5:61–69. https://doi.org/10.1016/j.impact.2017.01.001

Article  PubMed  PubMed Central  Google Scholar 

Zhou D, Sun Y, Qian Z et al (2023) Long-term dietary folic acid supplementation attenuated aging-induced hippocampus atrophy and promoted glucose uptake in 25-month-old rats with cognitive decline. J Nutr Biochem. https://doi.org/10.1016/j.jnutbio.2023.109328

Article  PubMed  Google Scholar 

Zhang Y, Ding C, Cai Y et al (2021) Astilbin ameliorates oxidative stress and apoptosis in D-galactose-induced senescence by regulating the PI3K/Akt/m-TOR signaling pathway in the brains of mice. Int Immunopharmacol 99:108035. https://doi.org/10.1016/j.intimp.2021.108035

Article  CAS  PubMed  Google Scholar 

Chen HI, Ou HC, Chen CY et al (2020) Neuroprotective effect of rhodiola crenulata in d-galactose-induced aging model. Am J Chin Med 48(2):373–390. https://doi.org/10.1142/S0192415X20500196

Article  CAS  PubMed  Google Scholar 

Chauhan A, Chauhan V (2020) Beneficial effects of walnuts on cognition and brain health. Nutrients. https://doi.org/10.3390/nu12020550

Article  PubMed  PubMed Central  Google Scholar