Tecalco-Cruz AC, Perez-Alvarado IA, Ramirez-Jarquin JO, Rocha-Zavaleta L (2017) Nucleo-cytoplasmic transport of estrogen receptor alpha in breast cancer cells. Cell Signal 34:121–132
Article CAS PubMed Google Scholar
S L-T, R S. The dynamics of estrogen receptor status in breast cancer: re-shaping the paradigm. Clinical Cancer Research. 2007; 13: 6921–6925.
Maehara K, Hida T, Abe Y, Koga A, Ota K, Kutoh E (2003) Functional interference between estrogen-related receptor alpha and peroxisome proliferator-activated receptor alpha/9-cis-retinoic acid receptor alpha heterodimer complex in the nuclear receptor response element-1 of the medium chain acyl-coenzyme A dehydrogenase gene. J Mol Endocrinol 31:47–60
Article CAS PubMed Google Scholar
Klinge CM (2001) Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res 29:2905–2919
Article CAS PubMed PubMed Central Google Scholar
Spears M, Bartlettt J (2009) The potential role of estrogen receptors and the SRC family as targets for the treatment of breast cancer. Expert Opin Ther Targets 13:665–674
Article CAS PubMed Google Scholar
Dhingra K (2001) Selective estrogen receptor modulation: the search for an ideal hormonal therapy for breast cancer. Cancer Invest 19:649–659
Article CAS PubMed Google Scholar
Salazar MD, Ratnam M, Patki M, Kisovic I, Trumbly R, Iman M et al (2011) During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor alpha1 apoprotein. Breast Cancer Res 13:R18
Article CAS PubMed PubMed Central Google Scholar
Marquez-Garban DC, Deng G, Comin-Anduix B, Garcia AJ, Xing Y, Chen HW et al (2019) Antiestrogens in combination with immune checkpoint inhibitors in breast cancer immunotherapy. J Steroid Biochem Mol Biol 193:105415
Article CAS PubMed PubMed Central Google Scholar
Jingwei Y, Kun D, Jialu H, Ruimin Z, Jianhong Z (2020) Progress in the understanding of the mechanism of tamoxifen resistance in breast cancer. Front Pharmacol 11:592912
Holm C, Kok M, Michalides R, Fles R, Koornstra RHT, Wesseling J et al (2009) Phosphorylation of the oestrogen receptor α at serine 305 and prediction of tamoxifen resistance in breast cancer. J Pathol 217:372–379
Article CAS PubMed Google Scholar
Conde C, Osswald M, Sunkel CE (2013) All together now Polo joins the kinase network controlling the spindle assembly checkpoint in Drosophila. Fly 7:224–228
Article CAS PubMed PubMed Central Google Scholar
Fisk HA, Mattison CP, Winey M (2003) Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression. Proc Natl Acad Sci USA 100:14875–14880
Article CAS PubMed PubMed Central Google Scholar
Hirschhorn T, Barizilay L, Smorodinsky NI, Ehrlich M (2012) Differential regulation of Smad3 and of the Type II transforming growth factor-beta receptor in mitosis: implications for signaling. PLoS ONE. https://doi.org/10.1371/journal.pone.0043459
Article PubMed PubMed Central Google Scholar
Li XD, Winey M (2012) The MPS1 family of protein kinases. Annu Rev Biochem 81:561–585
Yu ZC, Huang YF, Shieh SY (2016) Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. Nucleic Acids Res 44:1133–1150
Article CAS PubMed Google Scholar
Huang H, Yang Y, Zhang W, Liu X, Yang G (2020) TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt-mTOR pathway. FEBS Open Bio 10:1542–1549
Article CAS PubMed PubMed Central Google Scholar
Xie Y, Wang A, Lin J, Wu L, Zhang H, Yang X et al (2017) Mps1/TTK: a novel target and biomarker for cancer. J Drug Target 25:112–118
Article CAS PubMed Google Scholar
Zheng L, Chen Z, Kawakami M, Chen Y, Roszik J, Mustachio LM et al (2019) Tyrosine threonine kinase inhibition eliminates lung cancers by augmenting apoptosis and polyploidy. Mol Cancer Ther 18:1775–1786
Article CAS PubMed Google Scholar
Sugimoto Y, Sawant DB, Fisk HA, Mao L, Li C, Chettiar S et al (2017) Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorg Med Chem 25:2156–2166
Article CAS PubMed Google Scholar
Pachis ST, Kops G (2018) Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis. Open Biol. https://doi.org/10.1098/rsob.180109
Article PubMed PubMed Central Google Scholar
Kaistha BP, Honstein T, Muller V, Bielak S, Sauer M, Kreider R et al (2014) Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells. Br J Cancer 111:1780–1787
Article CAS PubMed PubMed Central Google Scholar
Changhua Z, Qiu Z et al (2012) Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration. Breast Cancer Res 14:R45
Kangaspeska S, Hultsch S, Jaiswal A, Edgren H, Mpindi J-P, Eldfors S, Brück O, Aittokallio T (2016) Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer. BMC Cancer 16:378–394
Article PubMed PubMed Central Google Scholar
Zheng XQ, Guo JP, Yang H, Kanai M, He LL, Li YY et al (2014) Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERalpha in breast cancer. Oncogene 33:4985–4996
Article CAS PubMed Google Scholar
Lange CA, Yee D (2011) Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer. Endocr Relat Cancer 18:C19-24
Article CAS PubMed PubMed Central Google Scholar
Schwartz JA, Zhong L, Deighton-Collins S, Zhao C, Skafar DF (2002) Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-alpha alter its response to estradiol and 4-hydroxytamoxifen. J Biol Chem 277:13202–13209
Article CAS PubMed Google Scholar
Lannigan DA (2003) Estrogen receptor phosphorylation. Steroids 68:1–9
Article CAS PubMed Google Scholar
Rayala SK, Talukder AH, Balasenthil S, Tharakan R, Barnes CJ, Wang RA et al (2006) P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res 66:1694–1701
Article CAS PubMed Google Scholar
Park S, Song J, Joe CO, Shin I (2008) Akt stabilizes estrogen receptor alpha with the concomitant reduction in its transcriptional activity. Cell Signal 20:1368–1374
Article CAS PubMed Google Scholar
Slee RB, Grimes BR, Bansal R, Gore J, Blackburn C, Brown L et al (2014) Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther 13:307–315
Article CAS PubMed Google Scholar
Daniel J, Coulter J, Woo JH, Wilsbach K, Gabrielson E (2011) High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells. Proc Natl Acad Sci U S A 108:5384–5389
Article CAS PubMed PubMed Central Google Scholar
Faisal A, Mak GWY, Gurden MD, Xavier CPR, Anderhub SJ, Innocenti P et al (2017) Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy. Br J Cancer 116:1166–1176
Article CAS PubMed PubMed Central Google Scholar
Jemaa M, Galluzzi L, Kepp O, Senovilla L, Brands M, Boemer U et al (2013) Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ 20:1532–1545
Article CAS PubMed PubMed Central Google Scholar
He X, Zheng Z, Song T, Wei C, Ma H, Ma Q et al (2010) c-Abl regulates estrogen receptor alpha transcription activity through its stabilization by phosphorylation. Oncogene 29:2238–2251
Comments (0)