Non-adherence and epileptic emergency—reasons and solutions

Kwan P, Brodie MJ (2000) Early identification of refractory epilepsy. N Engl J Med 342(5):314–319

Article  CAS  PubMed  Google Scholar 

Kalilani L, Sun X, Pelgrims B, Noack-Rink M, Villanueva V (2018) The epidemiology of drug-resistant epilepsy: a systematic review and meta-analysis. Epilepsia 59(12):2179–2193

Article  PubMed  Google Scholar 

Chen Z, Brodie MJ, Liew D, Kwan P (2018) Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study. JAMA Neurol 75(3):279–286

Article  PubMed  Google Scholar 

Callaghan BC, Anand K, Hesdorffer D, Hauser WA, French JA (2007) Likelihood of seizure remission in an adult population with refractory epilepsy. Ann Neurol 62(4):382–389

Article  PubMed  Google Scholar 

Asadi-Pooya AA (2005) Drug compliance of children and adolescents with epilepsy. Seizure 14(6):393–395

Article  PubMed  Google Scholar 

Manjunath R, Davis KL, Candrilli SD, Ettinger AB (2009) Association of antiepileptic drug nonadherence with risk of seizures in adults with epilepsy. Epilepsy Behav 14(2):372–378

Article  PubMed  Google Scholar 

Awan SA, Khawaja I, Babar M, Khan F (2022) Prevalence of non-adherence to antiepileptic drugs in patients with epilepsy presenting to emergency with fits. Cureus 14(7):e27072

PubMed  PubMed Central  Google Scholar 

Tan M, Allemann SS, Qin XS, D’Souza WJ (2023) Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: a data linkage study using dispensed prescriptions. Epilepsia 64(3):641–653

Article  PubMed  Google Scholar 

Mendorf S, Prell T, Schönenberg A (2022) Detecting reasons for nonadherence to medication in adults with epilepsy: a review of self-report measures and key predictors. J Clin Med 11(15):4308

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Cao W, Sun H, Wang X, Li S, Ran X et al (2022) Potential clinical and biochemical markers for the prediction of drug-resistant epilepsy: a literature review. Neurobiol Dis 174:105872

Article  CAS  PubMed  Google Scholar 

Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T et al (2016) A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 15(4):391–404

Article  PubMed  PubMed Central  Google Scholar 

Touchette D, Shapiro N (2008) Medication compliance, adherence, and persistence: current status of behavioral and educational interventions to improve outcomes. J Manag Care Pharm 14(6):S2–S10

Google Scholar 

Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T et al (2012) A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol 73(5):691–705

Article  PubMed  PubMed Central  Google Scholar 

Arnet I, Haefeli W (1998) Compliance: Fakten – Perspektiven. Manag Care 3:27–31

Google Scholar 

Aznar-Lou I, Fernández A, Gil-Girbau M, Fajó-Pascual M, Moreno-Peral P, Peñarrubia-María MT et al (2017) Initial medication non-adherence: prevalence and predictive factors in a cohort of 1.6 million primary care patients. Br J Clin Pharmacol 83(6):1328–1340

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blaschke TF, Osterberg L, Vrijens B, Urquhart J (2012) Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories. Annu Rev Pharmacol Toxicol 52(1):275–301

Article  CAS  PubMed  Google Scholar 

Brodie MJ, Barry SJ, Bamagous GA, Norrie JD, Kwan P (2012) Patterns of treatment response in newly diagnosed epilepsy. Neurology 78(20):1548–1554

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G et al (2010) Definition of drug resistant epilepsy: consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies. Epilepsia 51(6):1069–1077

Article  CAS  PubMed  Google Scholar 

Lerche H (2020) Drug-resistant epilepsy—time to target mechanisms. Nat Rev Neurol 16(11):595–596

Article  PubMed  Google Scholar 

Löscher W (2005) How to explain multidrug resistance in epilepsy? Epilepsy Curr 5(3):107–112

Article  PubMed  PubMed Central  Google Scholar 

Löscher W, Potschka H, Sisodiya SM, Vezzani A (2020) Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options. Pharmacol Rev 72(3):606–638

Article  PubMed  PubMed Central  Google Scholar 

Brodtkorb E, Samsonsen C, Sund JK, Bråthen G, Helde G, Reimers A (2016) Treatment non-adherence in pseudo-refractory epilepsy. Epilepsy Res 122:1–6

Article  PubMed  Google Scholar 

Karaźniewicz-Łada M, Główka AK, Mikulska AA, Główka FK (2021) Pharmacokinetic drug-drug interactions among antiepileptic drugs, including CBD, drugs used to treat COVID-19 and nutrients. Int J Mol Sci 22(17):9582. https://doi.org/10.3390/ijms22179582

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patsalos PN, Perucca E (2003) Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2(8):473–481

Article  CAS  PubMed  Google Scholar 

Johannessen SI, Landmark CJ (2010) Antiepileptic drug interactions—principles and clinical implications. Curr Neuropharmacol 8(3):254–267

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoppe B, Weber Y, Wolking S (2023) Interactions between anti-seizure medications and recommendations for combination treatment. Nervenarzt 94(2):149–158

Article  PubMed  Google Scholar 

Perucca E, Brodie MJ, Kwan P, Tomson T (2020) 30 years of second-generation antiseizure medications: impact and future perspectives. Lancet Neurol 19(6):544–556

Article  CAS  PubMed  Google Scholar 

Perucca E (2006) Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol 61(3):246–255

Article  CAS  PubMed  Google Scholar 

Giessmann T, May K, Modess C, Wegner D, Hecker U, Zschiesche M et al (2004) Carbamazepine regulates intestinal P‑glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. Clin Pharmacol Ther 76(3):192–200

Article  CAS  PubMed  Google Scholar 

de Boer A, van Hunsel F, Bast A (2015) Adverse food-drug interactions. Regul Toxicol Pharmacol 73(3):859–865

Article  PubMed  Google Scholar 

Kang YC, Chen MH, Lai SL (2015) Potentially unsafe herb-drug interactions between a commercial product of noni juice and phenytoin—a case report. Acta Neurol Taiwan 24(2):43–46

PubMed  Google Scholar 

Asadi-Pooya AA, Zeraatpisheh Z, Rostaminejad M, Damabi NM (2022) Caffeinated drinks, fruit juices, and epilepsy: a systematic review. Acta Neurol Scand 145(2):127–138

Article  PubMed  Google Scholar 

Alderson P (2004) Absence of evidence is not evidence of absence. Br Med J 328(7438):476–477

Article  Google Scholar 

Allemann S, Nieuwlaat R, van den Bemt B, Hersberger K, Arnet I (2016) Matching adherence interventions to patient determinants using the theoretical domains framework. Front Pharmacol 7:429

Article  PubMed  PubMed Central  Google Scholar 

Gadkari AS, McHorney CA (2012) Unintentional non-adherence to chronic prescription medications: how unintentional is it really? BMC Health Serv Res 12:98

Article  PubMed  PubMed Central  Google Scholar 

Wroe AL (2002) Intentional and unintentional nonadherence: a study of decision-making. J Behav Med 25(4):355–372

Article  PubMed  Google Scholar 

Castelan A, Nellen JF, van der Valk M, Nieuwkerk PT (2023) Intentional- but not unintentional medication non-adherence was related with beliefs about medicines among a multi-ethnic sample of people with HIV. AIDS Behav 27(4):1045–1054

Article  PubMed  Google Scholar 

Khatib R, Marshall K, Silcock J, Forrest C, Hall AS (2019) Adherence to coronary artery disease secondary prevention medicines: exploring modifiable barriers. Open Heart 6(2):e997

Article  PubMed  PubMed Central  Google Scholar 

Cadogan CA, Ryan C, Hughes CM (2016) Appropriate polypharmacy and medicine safety: when many is not too many. Drug Saf 39(2):109–116

Article  PubMed  Google Scholar 

Chapman SC, Horne R, Chater A, Hukins D, Smithson WH (2014) Patients’ perspectives on antiepileptic medication: relationships betwe

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