Khan, M. T., Verma, S. K., Maheshwari, S., Zahid, S. N. & Chaudhary, P. K. Neuromuscular dentistry: Occlusal diseases and posture. J. Oral. Biol. Craniofac. Res. 3, 146–150 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Sandoval-Munoz, C. P. & Haidar, Z. S. Neuro-Muscular Dentistry: the "diamond" concept of electro-stimulation potential for stomato-gnathic and oro-dental conditions. Head. Face Med 17, 16 (2021).

Article  Google Scholar 

Wang, G., Song, Z., Wang, J. & Qiu, C. Neuro-stomatology: an emerging inter-discipline worthy of attention. J. Chongqing Med. Univ. 46, 858–862 (2021).

Google Scholar 

Minoux, M. et al. Gene bivalency at Polycomb domains regulates cranial neural crest positional identity. Science 355, 11 (2017).

Article  Google Scholar 

Bataille, C. et al. Different sympathetic pathways control the metabolism of distinct bone envelopes. Bone 50, 1162–1172 (2012).

Article  PubMed  Google Scholar 

Nowinski, W. L. 3D Atlas of the brain, Head and Neck in 2953 pieces. Neuroinformatics 15, 395–400 (2017).

Article  PubMed  Google Scholar 

Shoja, M. M. et al. Anastomoses between lower cranial and upper cervical nerves: a comprehensive review with potential significance during skull base and neck operations, Part II: glossopharyngeal, vagus, accessory, and hypoglossal nerves and cervical spinal nerves 1-4. Clin. Anat. 27, 131–144 (2014).

Article  PubMed  Google Scholar 

Moss, M. L. An introduction to the neurobiology of oro-facial growth. Acta Biotheor. 21, 236–259 (1972).

Article  PubMed  Google Scholar 

Dierssen, M. Down syndrome: the brain in trisomic mode. Nat. Rev. Neurosci. 13, 844–858 (2012).

Article  PubMed  Google Scholar 

Messiaen, L. et al. Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome. JAMA J. Am. Med. Assoc. 302, 2111–2118 (2009).

Article  Google Scholar 

Yamanaka, S. et al. Circulatory CNP rescues craniofacial hypoplasia in Achondroplasia. J. Dent. Res. 96, 1526–1534 (2017).

Article  PubMed  Google Scholar 

Lv, X., Gao, F. & Cao, X. Skeletal interoception in bone homeostasis and pain. Cell Metab. 34, 1914–1931 (2022).

Article  PubMed  Google Scholar 

Cooper, R. R. Nerves in cortical bone. Science 160, 327–328 (1968).

Article  PubMed  Google Scholar 

Hohmann, E. L., Elde, R. P., Rysavy, J. A., Einzig, S. & Gebhard, R. L. Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers. Science 232, 868–871 (1986).

Article  PubMed  Google Scholar 

Dimitri, P. & Rosen, C. The central nervous system and bone metabolism: an evolving story. Calcif. Tissue Int. 100, 476–485 (2017).

Article  PubMed  Google Scholar 

Elefteriou, F. Impact of the autonomic nervous system on the skeleton. Physiol. Rev. 98, 1083–1112 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Wan, Q. Q. et al. Crosstalk between bone and nerves within bone. Adv. Sci. 8, 24 (2021).

Article  Google Scholar 

Fristad, I. Dental innervation: functions and plasticity after peripheral injury. Acta Odontol. Scand. 55, 236–254 (1997).

Article  PubMed  Google Scholar 

Kim, S. T. et al. Location of the mandibular canal and the topography of its neurovascular structures. J. Craniofac. Surg. 20, 936–939 (2009).

Article  PubMed  Google Scholar 

Renzi, G., Carboni, A., Perugini, M., Giovannetti, F. & Becelli, R. Posttraumatic trigeminal nerve impairment: a prospective analysis of recovery patterns in a series of 103 consecutive facial fractures. J. Oral. Maxillofac. Surg. 62, 1341–1346 (2004).

Article  PubMed  Google Scholar 

Tischfield, M. A. et al. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell 140, 74–87 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Newall, A. R., Orser, R. & Hunt, M. The control of oral secretions in bulbar ALS/MND. J. Neurol. Sci. 139, 43–44 (1996).

Article  PubMed  Google Scholar 

Tonomura, S. et al. Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study. Sci. Rep. 6, 9 (2016).

Article  Google Scholar 

Liu, X. H. et al. Perineural invasion in adenoid cystic carcinoma of the salivary glands: Where we are and where we need to go. Front. Oncol. 10, 10 (2020).

Google Scholar 

Saletu, A. et al. Controlled clinical and psychometric studies on the relation between periodontitis and depressive mood. J. Clin. Periodontol. 32, 1219–1225 (2005).

Article  PubMed  Google Scholar 

Harada, Y. et al. Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis. Pain 160, 2050–2062 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Labosky, P. A. & Kaestner, K. H. The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development. Mech. Dev. 76, 185–190 (1998).

Article  PubMed  Google Scholar 

Southard-Smith, E. M., Kos, L. & Pavan, W. J. Sox10 mutation disrupts neural crest development in DOM Hirschsprung mouse model. Nat. Genet 18, 60–64 (1998).

Article  PubMed  Google Scholar 

Martik, M. L. & Bronner, M. E. Riding the crest to get a head: neural crest evolution in vertebrates. Nat. Rev. Neurosci. 22, 616–626 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Chai, Y. et al. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127, 1671–1679 (2000).

Article  PubMed  Google Scholar 

Kulesa, P. M., Bailey, C. M., Kasemeier-Kulesa, J. C. & McLennan, R. Cranial neural crest migration: new rules for an old road. Dev. Biol. 344, 543–554 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Gong, S. G. Cranial neural crest: migratory cell behavior and regulatory networks. Exp. Cell Res. 325, 90–95 (2014).

Article  PubMed  Google Scholar 

AlSarheed, M. A comparative study of oral health amongst trisomy 21 children living in Riyadh, Saudi Arabia: Part 1 caries, malocclusion, trauma. Saudi. Dent. J. 27, 220–223 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Hanookai, D., Nowzari, H., Contreras, A., Morrison, J. L. & Slots, J. Herpesviruses and periodontopathic bacteria in trisomy 21 periodontitis. J. Periodont. 71, 376–384 (2000).

Article  PubMed  Google Scholar 

Díaz-Quevedo, A. A., Castillo-Quispe, H. M. L., Atoche-Socola, K. J. & Arriola-Guillén, L. E. Evaluation of the craniofacial and oral characteristics of individuals with Down syndrome: a review of the literature. J. Stomatol Oral. Maxillofac. Surg. 122, 583–587 (2021).

Article  PubMed  Google Scholar 

Suri, S., Tompson, B. D. & Atenafu, E. Prevalence and patterns of permanent tooth agenesis in Down syndrome and their association with craniofacial morphology. Angle Orthod. 81, 260–269 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Cuoghi, O. A. et al. Prevalence of dental anomalies in permanent dentition of brazilian individuals with down syndrome. Open Dent. J. 10, 469–473 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Nuernberg, M. A. A. et al. Periodontal status of individuals with Down syndrome: sociodemographic, behavioural and family perception influence. J. Intellect. Disabil. Res. 63, 1181–1192 (2019).

Article  PubMed  Google Scholar 

Lugović-Mihić, L., Pilipović, K., Crnarić, I., Šitum, M. & Duvančić, T. Differential diagnosis of cheilitis - how to classify cheilitis? Acta Clin. Croat. 57, 342–351 (2018).

PubMed  PubMed Central  Google Scholar 

Lott, I. T. & Head, E. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat. Rev. Neurol. 15, 135–147 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Ulualp, S. Outcomes of tongue base reduction and lingual tonsillectomy for residual pediatric obstructive sleep apnea after adenotonsillectomy. Int Arch. Otorhinolaryngol. 23, e415–e421 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Lammert, M., Friedman, J. M., Kluwe, L. & Mautner, V. F. Prevalence of neurofibromatosis 1 in German children at elementary school enrollment. Arch. Dermatol. 141, 71–74 (2005).

Article  PubMed  Google Scholar 

Rasmussen, S. A. & Friedman, J. M. NF1 gene and neurofibromatosis 1. Am. J. Epidemiol. 151, 33–40 (2000).

Article  PubMed  Google Scholar 

Singhal, D. et al. Craniofacial neurofibromatosis: treatment of the midface deformity. J. Cranio MaxilloFac. Surg. 42, 595–600 (2014).