Benmamar-Badel A, Owens T, Wlodarczyk A (2020) Protective microglial subset in development, aging, and disease: lessons from transcriptomic studies. Front Immunol 11:430

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Zhong D, Li G (2019) The role of microglia in viral encephalitis: a review. J Neuroinflammation 16:76

Article  PubMed  PubMed Central  Google Scholar 

Chhatbar C, Prinz M (2021) The roles of microglia in viral encephalitis: from sensome to therapeutic targeting. Cell Mol Immunol 18:250–258

Article  CAS  PubMed  Google Scholar 

Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL (2014) Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol 88:1080–1089

Article  PubMed  PubMed Central  Google Scholar 

Davis LE, DeBiasi R, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA, King MK, DeMasters BK, Tyler KL (2006) West Nile virus neuroinvasive disease. Ann Neurol 60:286–300

Article  PubMed  Google Scholar 

Feng W, Zhang Y, Wang Z, Xu H, Wu T, Marshall C, Gao J, Xiao M (2020) Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance. Alzheimers Res Ther 12:125

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franco R, Fernández-Suárez D (2015) Alternatively activated microglia and macrophages in the central nervous system. Prog Neurobiol 131:65–86

Article  CAS  PubMed  Google Scholar 

Ghoshal A, Das S, Ghosh S, Mishra MK, Sharma V, Koli P, Sen E, Basu A (2007) Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia 55:483–496

Article  PubMed  Google Scholar 

Han J, Zhu K, Zhang XM, Harris RA (2019) Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders. Glia 67:217–231

Article  PubMed  Google Scholar 

Hashemiaghdam A, Mroczek M (2020) Microglia heterogeneity and neurodegeneration: the emerging paradigm of the role of immunity in Alzheimer’s disease. J Neuroimmunol 341:577185

Article  CAS  PubMed  Google Scholar 

Healy LM, Zia S, Plemel JR (2022) Towards a definition of microglia heterogeneity. Commun Biol 5:1114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hickman S, Izzy S, Sen P, Morsett L, El Khoury J (2018) Microglia in neurodegeneration. Nat Neurosci 21:1359–1369

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jurga AM, Paleczna M, Kuter KZ (2020) Overview of general and discriminating markers of differential microglia phenotypes. Front Cell Neurosci 14:198

Article  PubMed  PubMed Central  Google Scholar 

Kadowaki H, Nishitoh H, Urano F, Sadamitsu C, Matsuzawa A, Takeda K, Masutani H, Yodoi J, Urano Y, Nagano T, Ichijo H (2005) Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ 12:19–24

Kenkhuis B, Somarakis A, Kleindouwel LRT, van Roon-Mom WMC, Höllt T, van der Weerd L (2022) Co-expression patterns of microglia markers Iba1, TMEM119, and P2RY12 in Alzheimer’s disease. Neurobiol Dis 167:105684

Article  CAS  PubMed  Google Scholar 

Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, David E, Baruch K, Lara-Astaiso D, Toth B, Itzkovitz S, Colonna M, Schwartz M, Amit I (2017) A unique microglia type associated with restricting development of Alzheimer’s disease. Cell 169:1276-1290.e17

Article  CAS  PubMed  Google Scholar 

Kobayashi S, Orba Y, Yamaguchi H, Kimura T, Sawa H (2012) Accumulation of ubiquitinated proteins is related to West Nile virus-induced neuronal apoptosis. Neuropathology 32:398–405

Article  PubMed  Google Scholar 

Kobayashi S, Yoshii K, Phongphaew W, Muto M, Hirano M, Orba Y, Sawa H, Kariwa H (2020) West Nile virus capsid protein inhibits autophagy by AMP-activated protein kinase degradation in neurological disease development. PLoS Pathog 16:e1008238

Konishi H, Kobayashi M, Kunisawa T, Imai K, Sayo A, Malissen B, Crocker PR, Sato K, Kiyama H (2017) Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes. Glia 65:1927–1943

Article  PubMed  Google Scholar 

Malmlov A, Bantle C, Aboellail T, Wagner K, Campbell CL, Eckley M, Chotiwan N, Gullberg RC, Perera R, Tjalkens R, Schountz T (2019) Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry of virus into brain via activated microglial cells. PLoS Negl Trop Dis 13:e0007071

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orihuela R, McPherson CA, Harry GJ (2016) Microglial M1/M2 polarization and metabolic states. Br J Pharmacol 173:649–665

Article  CAS  PubMed  Google Scholar 

Peng BH, Wang T (2019) West Nile virus induced cell death in the central nervous system. Pathogens 8

Petersen LR, Brault AC, Nasci RS (2013) West Nile virus: review of the literature. JAMA 310:308–315

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quick ED, Leser JS, Clarke P, Tyler KL (2014) Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection. J Virol 88:13005–13014

Article  PubMed  PubMed Central  Google Scholar 

Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi Y, Nagai H, Shimizu W, Saiki A, Ishikawa T, Elhanbly R, Kotani T, Murata Y, Saito Y, Naruse M, Shibasaki K, Oldenborg PA, Jung S, Matozaki T, Fukazawa Y, Ohnishi H (2019) Microglial SIRPα regulates the emergence of CD11c. Elife 8

Satoh JI, Kino Y, Yanaizu M, Ishida T, Saito Y (2019) Microglia express TMEM119 in the brains of Nasu-Hakola disease. Intractable Rare Dis Res 8:260–265

Article  PubMed  PubMed Central  Google Scholar 

Schoch CL, Ciufo S, Domrachev M, Hotton CL, Kannan S, Khovanskaya R, Leipe D, Mcveigh R, O'Neill K, Robbertse B, Sharma S, Soussov V, Sullivan JP, Sun L, Turner S, Karsch-Mizrachi I (2020) NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database (Oxford)

Seitz S, Clarke P, Tyler KL (2018) Pharmacologic depletion of microglia increases viral load in the brain and enhances mortality in murine models of flavivirus-induced encephalitis. J Virol 92

Shen X, Qiu Y, Wight AE, Kim HJ, Cantor H (2022) Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain. Proc Natl Acad Sci USA 119

Spiteri AG, Terry RL, Wishart CL, Ashhurst TM, Campbell IL, Hofer MJ, King NJC (2021) High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease. J Neuroinflammation 18:166

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stonedahl S, Clarke P, Tyler KL (2020) The role of microglia during West Nile virus infection of the central nervous system. Vaccines (Basel) 8

Stratoulias V, Venero JL, Tremblay M, Joseph B (2019) Microglial subtypes: diversity within the microglial community. EMBO J 38:e101997

Article  PubMed  PubMed Central  Google Scholar 

Takahashi K (2023) Microglial heterogeneity in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 82:140–149

Article  PubMed  Google Scholar 

Tan YL, Yuan Y, Tian L (2020) Microglial regional heterogeneity and its role in the brain. Mol Psychiatry 25:351–367

Article  PubMed  Google Scholar 

Todd BP, Chimenti MS, Luo Z, Ferguson PJ, Bassuk AG, Newell EA (2021) Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response. J Neuroinflammation 18:151

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ulbert S (2019) West Nile virus vaccines - current situation and future directions. Hum Vaccin Immunother 15:2337–2342

Article  PubMed  PubMed Central  Google Scholar 

Waltl I, Kalinke U (2022) Beneficial and detrimental functions of microglia during viral encephalitis. Trends Neurosci 45:158–170

Article  CAS  PubMed  Google Scholar 

Wendimu MY, Hooks SB (2022) Microglia phenotypes in aging and neurodegenerative diseases. Cells 11

Wlodarczyk A, Benmamar-Badel A, Cédile O, Jensen KN, Kramer I, Elsborg NB, Owens T (2018) CSF1R stimulation promotes increased neuroprotection by CD11c + microglia in EAE. Front Cell Neurosci 12:523

Article  CAS  PubMed  Google Scholar