Bilska M, Pawłowska A, Zakrzewska E, Chudzik A, Suszczyk D, Gogacz M et al (2020) Th17 Cells and IL-17 as novel immune targets in ovarian cancer therapy. J Oncol e8797683. https://doi.org/10.1155/2020/8797683
Cascão R, Moura RA, Perpétuo I, Canhão H, Vieira-Sousa E, Mourão AF et al (2010) Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis. Arthritis Res Ther 12:R196. https://doi.org/10.1186/ar3168
Article CAS PubMed PubMed Central Google Scholar
Castro G, Liu X, Ngo K, De Leon-Tabaldo A, Zhao S, Luna-Roman R et al (2017) RORγt and RORα signature genes in human Th17 cells. PLoS One 12:e0181868. https://doi.org/10.1371/journal.pone.0181868
Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A et al (2009) The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J Clin Invest 119:3011–3023. https://doi.org/10.1172/JCI39065
Article CAS PubMed PubMed Central Google Scholar
Chen P, Wang M, Li D, Jia Y, He N, Li W et al (2015) The Alteration and Clinical Significance of Th22/Th17/Th1 Cells in Patients with Chronic Myeloid Leukemia. J Immunol Res 2015:16123. https://doi.org/10.1155/2015/416123
Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS et al (2009) Critical regulation of early Th17 cell differentiation by IL-1 signaling. Immunity 30:576–587. https://doi.org/10.1016/j.immuni.2009.02.007
Article CAS PubMed PubMed Central Google Scholar
Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy - Dimensions. [cited 28 Mar 2021]. Available: https://app.dimensions.ai/details/patent/US-9272057-B2
Conroy T, Hammel P, Hebbar M, Ben Abdelghani M, Wei AC, Raoul J-L et al (2018) FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. N Engl J Med 379:2395–2406. https://doi.org/10.1056/NEJMoa1809775
Article CAS PubMed Google Scholar
De Simone V, Pallone F, Monteleone G, Stolfi C (2013) Role of TH17 cytokines in the control of colorectal cancer. Oncoimmunology 2:e26617. https://doi.org/10.4161/onci.26617
Duan Z, Miller HD, Fu X, Ge D, Jin B, Moustafa AA et al (2019) Th17 cells promote tumor growth in an immunocompetent orthotopic mouse model of prostate cancer. Am J Clin Exp Urol 7:249–261
PubMed PubMed Central Google Scholar
Egwuagu CE (2009) STAT3 in CD4+ T helper cell differentiation and inflammatory diseases. Cytokine 47:149–156. https://doi.org/10.1016/j.cyto.2009.07.003
Article CAS PubMed PubMed Central Google Scholar
Elessawi DF, Alkady MM, Ibrahim IM (2019) Diagnostic and prognostic value of serum IL-23 in colorectal cancer. Arab J Gastroenterol 20:65–68. https://doi.org/10.1016/j.ajg.2019.05.002
Fouser LA, Wright JF, Dunussi-Joannopoulos K, Collins M (2008) Th17 cytokines and their emerging roles in inflammation and autoimmunity. Immunol Rev 226:87–102. https://doi.org/10.1111/j.1600-065X.2008.00712.x
Article CAS PubMed Google Scholar
Gnerlich JL, Mitchem JB, Weir JS, Sankpal NV, Kashiwagi H, Belt BA et al (2010) Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer. J Immunol 185:4063–4071. https://doi.org/10.4049/jimmunol.0902609
Article CAS PubMed Google Scholar
He S, Fei M, Wu Y, Zheng D, Wan D, Wang L et al (2011) Distribution and Clinical Significance of Th17 Cells in the Tumor Microenvironment and Peripheral Blood of Pancreatic Cancer Patients. Int J Mol Sci 12:7424. https://doi.org/10.3390/ijms12117424
Article CAS PubMed PubMed Central Google Scholar
Hirota K, Martin B, Veldhoen M (2010) Development, regulation and functional capacities of Th17 cells. Semin Immunopathol 32:3–16. https://doi.org/10.1007/s00281-009-0187-y
Article CAS PubMed Google Scholar
Huang J, Lok V, Ngai CH, Zhang L, Yuan J, Lao XQ et al (2021) Worldwide Burden of, Risk Factors for, and Trends in Pancreatic Cancer. Gastroenterology 160:744–754. https://doi.org/10.1053/j.gastro.2020.10.007
Iida T, Iwahashi M, Katsuda M, Ishida K, Nakamori M, Nakamura M et al (2011) Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer. Oncol Rep 25:1271–1277. https://doi.org/10.3892/or.2011.1201
Article CAS PubMed Google Scholar
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ et al (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121–1133. https://doi.org/10.1016/j.cell.2006.07.035
Article CAS PubMed Google Scholar
Karabulut S, Afsar ÇU, Karabulut M, Alış H, Kılıc L, Çikot M et al (2016) Evaluation of Serum Interleukin-17 (IL-17) Levels as a Diagnostic Marker in Pancreatic Adenocarcinoma. J Gastrointest Cancer 47:47–54. https://doi.org/10.1007/s12029-015-9787-z
Article CAS PubMed Google Scholar
Karpisheh V, Ahmadi M, Abbaszadeh-Goudarzi K, Mohammadpour Saray M, Barshidi A, Mohammadi H et al (2022) The role of Th17 cells in the pathogenesis and treatment of breast cancer. Cancer Cell Int 22:108. https://doi.org/10.1186/s12935-022-02528-8
Article CAS PubMed PubMed Central Google Scholar
Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27:485–517. https://doi.org/10.1146/annurev.immunol.021908.132710
Article CAS PubMed Google Scholar
Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S et al (2009) Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 114:1141–1149. https://doi.org/10.1182/blood-2009-03-208249
Article CAS PubMed PubMed Central Google Scholar
Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, Kolls J et al (2007) Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment. J Immunol 178:6730–6733. https://doi.org/10.4049/jimmunol.178.11.6730
Article CAS PubMed Google Scholar
Lafdil F, Miller AM, Ki SH, Gao B (2010) Th17 cells and their associated cytokines in liver diseases. Cell Mol Immunol 7:250–254. https://doi.org/10.1038/cmi.2010.5
Article CAS PubMed PubMed Central Google Scholar
Liao Y, Wang B, Huang Z-L, Shi M, Yu X-J, Zheng L et al (2013) Increased circulating Th17 cells after transarterial chemoembolization correlate with improved survival in stage III hepatocellular carcinoma: a prospective study. PLoS One 8:e60444. https://doi.org/10.1371/journal.pone.0060444
Li Y, Jie Y, Wang X, Lu J (2021) Serum IL-35 is decreased in overweight patients with rheumatoid arthritis: its correlation with Th1/Th2/Th17-related cytokines. BMC Immunol 22:42. https://doi.org/10.1186/s12865-021-00431-x
Article CAS PubMed PubMed Central Google Scholar
Liu J, Duan Y, Cheng X, Chen X, Xie W, Long H et al (2011) IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma. Biochem Biophys Res Commun 407:348–354. https://doi.org/10.1016/j.bbrc.2011.03.021
Article CAS PubMed Google Scholar
Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI et al (2015) IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. Cancer Res 75:4852–4862. https://doi.org/10.1158/0008-5472.CAN-15-0896
Article CAS PubMed PubMed Central Google Scholar
Liu X, Jin H, Zhang G, Lin X, Chen C, Sun J et al (2014) Intratumor IL-17-positive mast cells are the major source of the IL-17 that is predictive of survival in gastric cancer patients. PLoS One 9:e106834. https://doi.org/10.1371/journal.pone.0106834
Lu T, Yu S, Liu Y, Yin C, Ye J, Liu Z et al (2016) Aberrant Circulating Th17 Cells in Patients with B-Cell Non-Hodgkin’s Lymphoma. Bertolini F, editor. PLoS One 11:e0148044. https://doi.org/10.1371/journal.pone.0148044
McAllister F, Leach SD (2014) Targeting IL-17 for pancreatic cancer prevention. Oncotarget 5:9530–9531
Article PubMed PubMed Central Google Scholar
Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A et al (2008) Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112:362–373. https://doi.org/10.1182/blood-2007-11-120998
Article CAS PubMed PubMed Central Google Scholar
Muranski P, Restifo NP (2013) Essentials of Th17 cell commitment and plasticity. Blood 121:2402–2414. https://doi.org/10.1182/blood-2012-09-378653
Article CAS PubMed PubMed Central Google Scholar
Miossec P (2009) IL-17 and Th17 cells in human inflammatory diseases. Microbes Infect 11:625–630. https://doi.org/10.1016/j.micinf.2009.04.003
Article CAS PubMed Google Scholar
Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D et al (2010) Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 304:1073–1081. https://doi.org/10.1001/jama.2010.1275
Article CAS PubMed Google Scholar
Parikh PY, Lillemoe KD (2015) Surgical Management of Pancreatic Cancer—Distal Pancreatectomy. Semin Oncol 42:110–122. https://doi.org/10.1053/j.seminoncol.2014.12.010
Pan B, Shen J, Cao J, Zhou Y, Shang L, Jin S et al (2015) Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer. Sci Rep 5:16053. https://doi.org/10.1038/srep16053
Article CAS PubMed PubMed Central Google Scholar
Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR, Heink S et al (2010) γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity 33:351–363. https://doi.org/10.1016/j.immuni.2010.08.013
Article CAS PubMed PubMed Central Google Scholar
Rauen T, Juang Y-T, Hedrich CM, Kis-Toth K, Tsokos GC (2012) A novel isoform of the orphan receptor RORγt suppresses IL-17 production in human T cells. Genes Immun 13:346–350. https://doi.org/10.1038/gene.2011.85
Comments (0)