The Next Challenges of Vestibular Implantation in Humans

Lucieer FMP, Van Hecke R, van Stiphout L, Duijn S, Pérez-Fornos A, Guinand N, Van Rompaey V, Kingma H, Joore M, van de Berg R (2020) Bilateral vestibulopathy: beyond imbalance and oscillopsia. J Neurol 267:241–255. https://doi.org/10.1007/s00415-020-10243-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun DQ, Ward BK, Semenov YR, Carey JP, Della Santina CC (2014) Bilateral vestibular deficiency: quality of life and economic implications. JAMA Otolaryngol - Head Neck Surg 140:527–534. https://doi.org/10.1001/jamaoto.2014.490

Article  PubMed  PubMed Central  Google Scholar 

Lucieer F, Vonk P, Guinand N, Stokroos R, Kingma H, van de Berg R (2016) Bilateral vestibular hypofunction: insights in etiologies, clinical subtypes, and diagnostics. Front Neurol 7:26. https://doi.org/10.3389/fneur.2016.00026

Article  CAS  PubMed  PubMed Central  Google Scholar 

Porciuncula F, Johnson CC, Glickman LB (2012) The effect of vestibular rehabilitation on adults with bilateral vestibular hypofunction: a systematic review. J Vestib Res Equilib Orientat 22:283–298. https://doi.org/10.3233/VES-120464

Article  Google Scholar 

Ward BK, Agrawal Y, Hoffman HJ, Carey JP, Della Santina CC (2013) Prevalence and impact of bilateral vestibular hypofunction: results from the 2008 US national health interview survey. JAMA Otolaryngol - Head Neck Surg 139:803–810. https://doi.org/10.1001/jamaoto.2013.3913

Article  PubMed  PubMed Central  Google Scholar 

Kingma H, van de Berg R (2016) Anatomy, physiology, and physics of the peripheral vestibular system. In: Furman JM, Lempert T (eds.) Handbook of Clinical Neurology, vol. 137. Elsevier B.V., pp.1–16. https://doi.org/10.1016/B978-0-444-63437-5.00001-7

Berthold E (1874) Ueber die Function der Bogengänge des Ohrlabyrinths. Arch für Ohrenheilkd 9:77–95. https://doi.org/10.1007/BF01803958

Article  Google Scholar 

Breuer J (1874) Ueber die Function der Bogengänge des Ohrlabyrinthes. Medizinische Jahrbücher 72–124.

Suzuki JI, Cohen B, Bender MB (1964) Compensatory eye movements induced by vertical semicircular canal stimulation. Exp Neurol 9:137–160. https://doi.org/10.1016/0014-4886(64)90013-5

Article  CAS  PubMed  Google Scholar 

Cohen B, Suzuki JI, Bender MB (1964) Eye movements from semicircular canal nerve stimulation in the cat. Ann Otol Rhinol Laryngol 73:153–169. https://doi.org/10.1177/000348946407300116

Article  CAS  PubMed  Google Scholar 

Suzuki JI, Goto K, Tokumasu K, Cohen B (1969) Implantation of electrodes near individual vestibular nerve branches in mammals. Ann Otol Rhinol Laryngol 78:815–826. https://doi.org/10.1177/000348946907800414

Article  CAS  PubMed  Google Scholar 

Goldberg JM, Smith CE, Fernández C (1984) Relation between discharge regularity and responses to externally applied galvanic currents in vestibular nerve afferents of the squirrel monkey. J Neurophysiol 51:1236–1256. https://doi.org/10.1152/jn.1984.51.6.1236

Article  CAS  PubMed  Google Scholar 

Smith CE, Goldberg JM (1986) A stochastic afterhyperpolarization model of repetitive activity in vestibular afferents. Biol Cybern 54:41–51. https://doi.org/10.1007/BF00337114

Article  CAS  PubMed  Google Scholar 

Robinson DA (1982) The use of matrices in analyzing the three-dimensional behavior of the vestibulo-ocular reflex. Biol Cybern 46:53–66. https://doi.org/10.1007/BF00335351

Article  CAS  PubMed  Google Scholar 

Schultheis LW, Robinson DA (1981) Directional plasticity of the vestibuloocular reflex in the cat. Ann N Y Acad Sci 374:504–512. https://doi.org/10.1111/j.1749-6632.1981.tb30895.x

Article  CAS  PubMed  Google Scholar 

Melvill Jones G, Guitton D, Berthoz A (1988) Changing patterns of eye-head coordination during 6 h of optically reversed vision. Exp brain Res 69:531–544. https://doi.org/10.1007/BF00247307

Article  CAS  PubMed  Google Scholar 

Gong W, Merfeld DM (2000) Prototype neural semicircular canal prosthesis using patterned electrical stimulation. Ann Biomed Eng 28:572–581. https://doi.org/10.1114/1.293

Article  CAS  PubMed  Google Scholar 

Gong W, Merfeld DM (2002) System design and performance of a unilateral horizontal semicircular canal prosthesis. IEEE Trans Biomed Eng 49:175–181. https://doi.org/10.1109/10.979358

Article  PubMed  Google Scholar 

Merfeld DM, Haburcakova C, Gong W, Lewis RF (2007) Chronic vestibulo-ocular reflexes evoked by a vestibular prosthesis. IEEE Trans Biomed Eng 54:1005–1015. https://doi.org/10.1109/TBME.2007.891943

Article  PubMed  Google Scholar 

Nie K, Ling L, Bierer SM, Kaneko CRS, Fuchs AF, Oxford T, Rubinstein JT, Phillips JO (2013) An experimental vestibular neural prosthesis: design and preliminary results with rhesus monkeys stimulated with modulated pulses. IEEE Trans Biomed Eng 60:1685–1692. https://doi.org/10.1109/TBME.2013.2241433

Article  PubMed  Google Scholar 

Phillips C, Ling L, Oxford T, Nowack A, Nie K, Rubinstein JT, Phillips JO (2015) Longitudinal performance of an implantable vestibular prosthesis. Hear Res 322:200–211. https://doi.org/10.1016/j.heares.2014.09.003

Article  PubMed  Google Scholar 

Lewis RF, Haburcakova C, Gong W, Makary C, Merfeld DM (2010) Vestibuloocular reflex adaptation investigated with chronic motion-modulated electrical stimulation of semicircular canal afferents. J Neurophysiol 103:1066–1079. https://doi.org/10.1152/jn.00241.2009

Article  PubMed  Google Scholar 

Lewis RF, Nicoucar K, Gong W, Haburcakova C, Merfeld DM (2013) Adaptation of vestibular tone studied with electrical stimulation of semicircular canal afferents. J Assoc Res Otolaryngol 14:331–340. https://doi.org/10.1007/s10162-013-0376-1

Article  PubMed  PubMed Central  Google Scholar 

Della Santina CC, Migliaccio AA, Patel AH (2007) A multichannel semicircular canal neural prosthesis using electrical stimulation to restore 3-d vestibular sensation. IEEE Trans Biomed Eng 54:1016–1030. https://doi.org/10.1109/TBME.2007.894629

Article  PubMed  PubMed Central  Google Scholar 

Fridman GY, Davidovics NS, Dai C, Migliaccio AA, Della Santina CC (2010) Vestibulo-ocular reflex responses to a multichannel vestibular prosthesis incorporating a 3D coordinate transformation for correction of misalignment. J Assoc Res Otolaryngol 11:367–381. https://doi.org/10.1007/s10162-010-0208-5

Article  PubMed  PubMed Central  Google Scholar 

Dai C, Fridman GY, Chiang B, Davidovics NS, Melvin T-A, Cullen KE, Della Santina CC (2011) Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesis. Exp brain Res 210:595–606. https://doi.org/10.1007/s00221-011-2591-5

Article  PubMed  PubMed Central  Google Scholar 

Dai C, Fridman GY, Davidovics NS, Chiang B, Ahn JH, Della Santina CC (2011) Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis. Hear Res 281:74–83. https://doi.org/10.1016/j.heares.2011.08.008

Article  PubMed  PubMed Central  Google Scholar 

Rubinstein JT, Nie K, Bierer S, Ling L, Phillips JO (2010) Signal processing for a vestibular neurostimulator. Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Int Conf 2010:6247. https://doi.org/10.1109/IEMBS.2010.5628064

Article  Google Scholar 

Phillips JO, Shepherd SJ, Nowack AL, Ling L, Bierer SM, Kaneko CRS, Phillips CMT, Nie K, Rubinstein JT (2012) Longitudinal performance of a vestibular prosthesis as assessed by electrically evoked compound action potential recording. Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Int Conf 2012:6128–6131. https://doi.org/10.1109/EMBC.2012.6347392

Article  Google Scholar 

Wall C, Kos MI, Guyot JP (2007) Eye movements in response to electric stimulation of the human posterior ampullary nerve. Ann Otol Rhinol Laryngol 116:369–374. https://doi.org/10.1177/000348940711600509

Article  PubMed  Google Scholar 

Pérez-Fornos A, Guinand N, van de Berg R, Stokroos R, Micera S, Kingma H, Pelizzone M, Guyot JP (2014) Artificial balance: restoration of the vestibulo-ocular reflex in humans with a prototype vestibular neuroprosthesis. Front Neurol 5:66. https://doi.org/10.3389/fneur.2014.00066

Rubinstein JT, Bierer S, Kaneko C, Ling L, Nie K, Oxford T, Newlands S, Santos F, Risi F, Abbas PJ, Phillips JO (2012) Implantation of the semicircular canals with preservation of hearing and rotational sensitivity: a vestibular neurostimulator suitable for clinical research. Otol Neurotol 33:789–796. https://doi.org/10.1097/MAO.0b013e318254ec24

Article  PubMed  PubMed Central  Google Scholar 

Boutros PJ, Schoo DP, Rahman M, Valentin NS, Chow MR, Ayiotis AI, Morris BJ, Hofner A, Rascon AM, Marx A, Deas R, Fridman GY, Davidovics NS, Ward BK, Treviño C, Bowditch SP, Roberts DC, Lane KE, Gimmon Y, Schubert MC, Carey JP, Jaeger A, Della Santina CC (2019) Continuous vestibular implant stimulation partially restores eye-stabilizing reflexes. JCI Insight 4. https://doi.org/10.1172/jci.insight.128397

Stultiens J, van de Berg R, Lewis R, Della Santina C, Van Stiphout L, Phillips J, Boutabla A, Glueckert R (2021) Symposium 9. The Next challenges of vestibular implantation in humans. In: The Association for Research in Otolaryngology (ARO) 44th Annual MidWinter Meeting. San Jose, CA, USA, pp 28–29.

Lewis RF (2016) Vestibular implants studied in animal models: clinical and scientific implications. J Neurophysiol 116:2777–2788. https://doi.org/10.1152/jn.00601.2016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merfeld DM, Gong W, Morrissey J, Saginaw M, Haburcakova C, Lewis RF (2006) Acclimation to chronic constant-rate peripheral stimulation provided by a vestibular prosthesis. IEEE Trans Biomed Eng 53:2362–2372. https://doi.org/10.1109/TBME.2006.883645

Article  PubMed  Google Scholar 

Lewis RF, Haburcakova C, Gong W, Karmali F, Merfeld DM (2012) Spatial and temporal properties of eye movements produced by electrical stimulation of semicircular canal afferents. J Neurophysiol 108:1511–1520. https://doi.org/10.1152/jn.01029.2011

Article  PubMed  PubMed Central  Google Scholar 

Lewis RF, Haburcakova C, Merfeld DM (2008) Roll tilt psychophysics in rhesus monkeys during vestibular and visual stimulation. J Neurophysiol 100:140–153. https://doi.org/10.1152/jn.01012.2007

Article  PubMed  PubMed Central  Google Scholar 

Lewis RF, Haburcakova C, Gong W, Lee D, Merfeld D (2013) Electrical stimulation of semicircular canal afferents affects the perception of head orientation. J Neurosci 33:9530–9535. https://doi.org/10.1523/JNEUROSCI.0112-13.2013

Article  CAS  PubMed  PubMed Central  Google Scholar 

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