Hooper LG, Kaufman JD. Ambient air pollution and clinical implications for susceptible populations. Ann Am Thorac Soc. 2018;15(Suppl 2):S64–8.
Article PubMed PubMed Central Google Scholar
Health impacts [Internet]. [cited 2023 Apr 21]. Available from https://www.who.int/teams/environment-climate-change-and-health/air-quality-and-health/health-impacts.
Khreis H, Kelly C, Tate J, Parslow R, Lucas K, Nieuwenhuijsen M. Exposure to traffic-related air pollution and risk of development of childhood asthma: a systematic review and meta-analysis. Environ Int. 2017;100:1–31.
Article CAS PubMed Google Scholar
Burbank AJ, Peden DB. Assessing the impact of air pollution on childhood asthma morbidity: how, when and what to do. Curr Opin Allergy Clin Immunol. 2018;18(2):124–31.
Article PubMed PubMed Central Google Scholar
To T, Zhu J, Stieb D, Gray N, Fong I, Pinault L, et al. Early life exposure to air pollution and incidence of childhood asthma, allergic rhinitis and eczema. Eur Respir J [Internet]. 2020 Feb 1 [cited 2023 Apr 21];55(2). Available from https://erj.ersjournals.com/content/55/2/1900913.
Altman MC, Kattan M, O’Connor GT, Murphy RC, Whalen E, LeBeau P, et al. Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis. Lancet Planet Health. 2023;7(1):e33–44.
Article PubMed PubMed Central Google Scholar
Thurston GD, Balmes JR, Garcia E, Gilliland FD, Rice MB, Schikowski T, et al. Outdoor air pollution and new-onset airway disease. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2020;17(4):387–98.
Doiron D, Hoogh K de, Probst-Hensch N, Fortier I, Cai Y, Matteis SD, et al. Air pollution, lung function and COPD: results from the population-based UK Biobank study. Eur Respir J [Internet]. 2019 Jul 1 [cited 2023 Apr 21];54(1). Available from https://erj.ersjournals.com/content/54/1/1802140.
• Milner J, Hamilton I, Woodcock J, Williams M, Davies M, Wilkinson P, et al. Health benefits of policies to reduce carbon emissions. BMJ [Internet]. 2020 Mar 30 [cited 2023 Apr 21];368. Available from https://www.bmj.com/content/368/bmj.l6758. Summary of actions to reduce emissions.
Brugge D, Patton AP, Bob A, Reisner E, Lowe L, Bright O-JM, et al. Developing community-level policy and practice to reduce traffic-related air pollution exposure. Environ Justice Print. 2015 Jun;8(3):95–104.
Davison G, Barkjohn KK, Hagler GSW, Holder AL, Coefield S, Noonan C, et al. Creating clean air spaces during wildland fire smoke episodes: web summit summary. Front Public Health [Internet]. 2021 Feb 15 [cited 2023 Apr 21];9. Available from https://doi.org/10.3389/fpubh.2021.508971/full.
Laumbach RJ, Cromar KR. Personal interventions to reduce exposure to outdoor air pollution. Annu Rev Public Health. 2022;43(1):293–309.
• The evidence is clear: the time for action is now. We can halve emissions by 2030. — IPCC [Internet]. [cited 2023 Apr 21]. Available from https://www.ipcc.ch/2022/04/04/ipcc-ar6-wgiii-pressrelease/. Intergovernmental Panel on Climate Change report regarding the state of the science on global emissions and climate change.
House TW. FACT SHEET: Biden administration launches effort to improve ventilation and reduce the spread of COVID-19 in buildings [Internet]. The White House. 2022 [cited 2023 Apr 21]. Available from https://www.whitehouse.gov/briefing-room/statements-releases/2022/03/17/fact-sheet-biden-administration-launches-effort-to-improve-ventilation-and-reduce-the-spread-of-covid-19-in-buildings/.
Ramírez AS, Ramondt S, Van Bogart K, Zuniga RP. Public awareness of air pollution and health threats: challenges and opportunities for communication strategies to improve environmental health literacy. J Health Commun. 2019;24(1):75–83.
Article PubMed PubMed Central Google Scholar
Reports [Internet]. Global initiative for asthma - GINA. [cited 2023 Apr 21]. Available from https://ginasthma.org/reports/.
Brigham EP, West NE. Diagnosis of asthma: diagnostic testing. Int Forum Allergy Rhinol. 2015;5(S1):S27–30.
• Kuruvilla ME, Lee FE-H, Lee GB. Understanding asthma phenotypes, endotypes, and mechanisms of disease. Clin Rev Allergy Immunol. 2019;56(2):219–33. A key review of endotypes, phenotypes, and biologic pathways in asthma.
Kaur R, Chupp G. Phenotypes and endotypes of adult asthma: moving toward precision medicine. J Allergy Clin Immunol. 2019;144(1):1–12.
Calhoun WJ, Chupp GL. The new era of add-on asthma treatments: where do we stand? Allergy Asthma Clin Immunol. 2022;18(1):42.
Article PubMed PubMed Central Google Scholar
Svenningsen S, Nair P. Asthma endotypes and an overview of targeted therapy for asthma. Front Med [Internet]. 2017 [cited 2023 Apr 21];4. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622943/.
Fahy JV. Type 2 inflammation in asthma — present in most, absent in many. Nat Rev Immunol. 2015;15(1):57–65.
Article CAS PubMed PubMed Central Google Scholar
Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006;203(6):1435–46.
Article CAS PubMed PubMed Central Google Scholar
Patel NN, Kohanski MA, Maina IW, Workman AD, Herbert DR, Cohen NA. Sentinels at the wall: epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation. Int Forum Allergy Rhinol. 2019;9(1):93–9.
Poulsen LK, Hummelshoj L. Triggers of IgE class switching and allergy development. Ann Med. 2007;39(6):440–56.
Article CAS PubMed Google Scholar
Locksley RM. Asthma and Allergic Inflammation. Cell. 2010;140(6):777–83.
Article CAS PubMed PubMed Central Google Scholar
Coverstone AM, Seibold MA, Peters MC. Diagnosis and management of T2-high asthma. J Allergy Clin Immunol Pract. 2020;8(2):442–50.
Payton AD, Perryman AN, Hoffman JR, Avula V, Wells H, Robinette C, et al. Cytokine signature clusters as a tool to compare changes associated with tobacco product use in upper and lower airway samples. Am J Physiol-Lung Cell Mol Physiol. 2022;322(5):L722–36.
Article PubMed PubMed Central Google Scholar
Holgate ST, Wenzel S, Postma DS, Weiss ST, Renz H, Sly PD. Asthma Nat Rev Dis Primer. 2015;1(1):15025.
• Fitzpatrick AM, Chipps BE, Holguin F, Woodruff PG. T2-“low” asthma: overview and management strategies. J Allergy Clin Immunol Pract. 2020;8(2):452–63. Key review of T2-low asthma, for which fewer targeted treatment strategies are available.
Kyriakopoulos C, Gogali A, Bartziokas K, Kostikas K. Identification and treatment of T2-low asthma in the era of biologics. ERJ Open Res [Internet]. 2021 [cited 2023 Apr 22];7(2). Available from https://openres.ersjournals.com/content/7/2/00309-2020.
Papaioannou AI, Diamant Z, Bakakos P, Loukides S. Towards precision medicine in severe asthma: Treatment algorithms based on treatable traits. Respir Med. 2018;1(142):15–22.
Tliba O, Panettieri RA. Paucigranulocytic asthma: uncoupling of airway obstruction from inflammation. J Allergy Clin Immunol. 2019;143(4):1287–94.
Menzies-Gow A, Corren J, Bourdin A, Chupp G, Israel E, Wechsler ME, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800–9.
Article CAS PubMed Google Scholar
Parnes JR, Molfino NA, Colice G, Martin U, Corren J, Menzies-Gow A. Targeting TSLP in asthma. J Asthma Allergy. 2022;3(15):749–65.
Wu AY, Peebles RS. The emerging role of IL-23 in asthma and its clinical implications. Expert Rev Clin Immunol. 2023;19(1):1–5.
Article CAS PubMed Google Scholar
Peebles RS, Aronica MA. Proinflammatory pathways in the pathogenesis of asthma. Clin Chest Med. 2019;40(1):29–50.
Article PubMed PubMed Central Google Scholar
Zakeri A, Russo M. Dual role of toll-like receptors in human and experimental asthma models. Front Immunol. 2018;15(9):1027.
Shilovskiy IP, Nikolskii AA, Kurbacheva OM, Khaitov MR. Modern view of neutrophilic asthma molecular mechanisms and therapy. Biochem Mosc. 2020;85(8):854–68.
Sze E, Bhalla A, Nair P. Mechanisms and therapeutic strategies for non-T2 asthma. Allergy. 2020;75(2):311–25.
Kunkel SL, Standiford T, Kasahara K, Strieter RM. Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung. Exp Lung Res. 1991;17(1):17–23.
Article CAS PubMed Google Scholar
•• Nair P, Surette MG, Virchow JC. Neutrophilic asthma: misconception or misnomer? Lancet Respir Med. 2021;9(5):441–3. Reconsideration of airway neutrophilia as a more common response to several noxious exposures (including air pollution), and contextualization within the definition of neutrophilic asthma.
Article CAS PubMed Google Scholar
Crisford H, Sapey E, Rogers GB, Taylor S, Nagakumar P, Lokwani R, et al. Neutrophils in asthma: the good, the bad and the bacteria. Thorax. 2021;76(8):835–44.
Wenzel S. Asthma: defining of the persistent adult phenotypes. Lancet. 2006;1(368):804–13.
Pignatti P, Visca D, Cherubino F, Zampogna E, Saderi L, Zappa M, et al. Mixed granulocytic phenotype in asthmatic patients. Eur Respir J [Internet]. 2019 [cited 2023 Apr 8];54(suppl 63). Available from https://erj.ersjournals.com/content/54/suppl_63/PA2587.
Chu DK, Al-Garawi A, Llop-Guevara A, Pillai RA, Radford K, Shen P, et al. Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma. Allergy Asthma Clin Immunol. 2015;11(1):14.
Article PubMed PubMed Central Google Scholar
Therapeutic efficacy of IL-17A neutralization with corticosteroid treatment in a model of antigen-driven mixed-granulocytic asthma | Am J Physiol Lung Cell Mol Physiol [Internet]. [cited 2023 Apr 22]. Available from https://doi.org/10.1152/ajplung.00204.2020.
Pleil JD, Wallace MAG, Davis MD, Matty CM. The physics of human breathing: flow, timing, volume, and pressure parameters for normal, on-demand, and ventilator respiration. J Breath Res. 2021;15(4). https://doi.org/10.1088/1752-7163/ac2589.
Carvalho TC, Peters JI, Williams RO. Influence of particle size on regional lung deposition – what evidence is there? Int J Pharm. 2011;406(1):1–10.
Article CAS PubMed Google Scholar
•• Particle deposition in the respiratory tract. [Internet]. [cited 2023 Apr 22]. Available from https://www.scopus.com/record/display.uri?eid=2-s2.0-79951576216&origin=inward&txGid=aabeb681787c61e2c095da845c02f6de. Description of respiratory penetration of particles by size in the respiratory tract, fundamental to understanding of respiratory particulate matter exposure.
• Passage of Inhaled Particles Into the Blood Circulation in Humans | Circulation [Internet]. [cited 2023 Apr 22]. Available from https://doi.org/10.1161/hc0402.104118. Evidence of translocation of particulate matter air pollution into the systemic circulation.
Kwon H-S, Ryu MH, Carlsten C. Ultrafine particles: unique physicochemical properties relevant to health and disease. Exp Mol Med. 2020;52(3):318–28.
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