Van Bekkum, D., Vos, O. & Weyzen, W. W. The pathogenesis of the secondary disease after foreign bone marrow transplantation in X-irradiated mice. J. Natl Cancer Inst. 23, 75–89 (1959).
Billingham, R. E. The biology of graft-versus-host reactions. Harvey Lect. 62, 21–78 (1966).
Passweg, J. R. et al. Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years. Bone Marrow Transplant. https://doi.org/10.1038/s41409-021-01227-8 (2021).
Article PubMed PubMed Central Google Scholar
Passweg, J. R. et al. Impact of the SARS-CoV-2 pandemic on hematopoietic cell transplantation and cellular therapies in Europe 2020: a report from the EBMT activity survey. Bone Marrow Transplant. 57, 742–752 (2022).
Article CAS PubMed PubMed Central Google Scholar
Niederwieser, D. et al. One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors. Haematologica 107, 1045–1053 (2022).
Holtan, S. G. et al. Disease progression, hospital readmissions, and clinical outcomes for patients with steroid-refractory acute graft-versus-host disease: a multicenter, retrospective study. Bone Marrow Transplant. 57, 1399–1404 (2022).
Article CAS PubMed PubMed Central Google Scholar
Filipovich, A. H. et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group report. Biol. Blood Marrow Transplant. 11, 945–956 (2005). This article reports the refined classification by the NIH that established that acute and chronic GVHD should be distinguished based on GVHD features and not time of onset.
Jagasia, M. H. et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. Biol. Blood Marrow Transplant. 21, 389–401.e1 (2015).
Harris, A. C. et al. International, multicenter standardization of acute graft-versus-host disease clinical data collection: a report from the Mount Sinai Acute GVHD International Consortium. Biol. Blood Marrow Transplant. 22, 4–10 (2016). This article refines acute GVHD diagnosis criteria to allow better standardization of data collection.
Cahn, J. Y. et al. Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: a joint Société Française de Greffe de Moëlle et Thérapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI), and International Bone Marrow Transplant Registry (IBMTR) prospective study. Blood 106, 1495–1500 (2005).
Article CAS PubMed PubMed Central Google Scholar
Schoemans, H. M. et al. The eGVHD app has the potential to improve the accuracy of graft-versus-host disease assessment: a multicenter randomized controlled trial. Haematologica 103, 1698–1707 (2018).
Article PubMed PubMed Central Google Scholar
Schoemans, H. M. et al. Accuracy and usability of the eGVHD app in assessing the severity of graft-versus-host disease at the 2017 EBMT annual congress. Bone Marrow Transplant. 53, 490–494 (2018).
Thomas, E. D. et al. One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood 49, 511–533 (1977).
Article CAS PubMed Google Scholar
Reshef, R. et al. Acute GVHD diagnosis and adjudication in a multicenter trial: a report from the BMT CTN 1202 biorepository study. J. Clin. Oncol. 39, 1878–1887 (2021).
Article PubMed PubMed Central Google Scholar
Greinix, H. T. et al. Improved outcome of patients with graft-versus-host disease after allogeneic hematopoietic cell transplantation for hematologic malignancies over time: an EBMT mega-file study. Haematologica 107, 1054–1063 (2022). This paper is the largest and most recent analysis of acute GVHD incidence, risk factors and outcomes.
Article CAS PubMed Google Scholar
Mielcarek, M. et al. Effects of race on survival after stem cell transplantation. Biol. Blood Marrow Transplant. 11, 231–239 (2005).
Sigmund, A. M. et al. Impact of race and geographic area of residence on outcomes after allogeneic stem cell transplant. Front. Oncol. https://doi.org/10.3389/fonc.2022.801879 (2022).
Article PubMed PubMed Central Google Scholar
Hamilton, B. K. et al. Racial differences in allogeneic hematopoietic cell transplantation outcomes among African Americans and whites. Bone Marrow Transplant. 50, 834–839 (2015).
Article CAS PubMed Google Scholar
Morishima, Y. et al. Significance of ethnicity in the risk of acute graft-versus-host disease and leukemia relapse after unrelated donor hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. 19, 1197–1203 (2013).
Article PubMed PubMed Central Google Scholar
Kanda, J. et al. Graft-versus-host disease after HLA-matched sibling bone marrow or peripheral blood stem cell transplantation: comparison of North American Caucasian and Japanese populations. Biol. Blood Marrow Transplant. 22, 744–751 (2016).
Article CAS PubMed PubMed Central Google Scholar
Khoury, H. J. et al. Improved survival after acute graft-versus-host disease diagnosis in the modern era. Haematologica 102, 958–966 (2017).
Article PubMed PubMed Central Google Scholar
El-Jawahri, A. et al. Improved treatment-related mortality and overall survival of patients with grade IV acute GVHD in the modern years. Biol. Blood Marrow Transplant. 22, 910–918 (2016).
Flowers, M. E. et al. Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria. Blood 117, 3214–3219 (2011).
Article CAS PubMed PubMed Central Google Scholar
Lee, S. J. et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 110, 4576–4583 (2007).
Article CAS PubMed Google Scholar
Hahn, T. et al. Risk factors for acute graft-versus-host disease after human leukocyte antigen-identical sibling transplants for adults with leukemia. J. Clin. Oncol. 26, 5728–5734 (2008).
Article PubMed PubMed Central Google Scholar
Gale, R. P. et al. Risk factors for acute graft-versus-host disease. Br. J. Haematol. 67, 397–406 (1987).
Article CAS PubMed Google Scholar
Kollman, C. et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 98, 2043–2051 (2001).
Article CAS PubMed Google Scholar
Bacigalupo, A. Post-transplant cyclophosphamide: overcoming the HLA barrier to hematopoietic stem cell transplants. Haematologica 107, 1230–1231 (2022).
Article PubMed PubMed Central Google Scholar
Im, A. et al. Risk factors for graft-versus-host disease in haploidentical hematopoietic cell transplantation using post-transplant cyclophosphamide. Biol. Blood Marrow Transplant. 26, 1459–1468 (2020).
Article CAS PubMed PubMed Central Google Scholar
Hansen, J. A., Chien, J. W., Warren, E. H., Zhao, L. P. & Martin, P. J. Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation. Curr. Opin. Hematol. 17, 483–492 (2010).
Article PubMed PubMed Central Google Scholar
Antin, J. H. & Ferrara, J. L. Cytokine dysregulation and acute graft-versus-host disease. Blood 80, 2964–2968 (1992).
Article CAS PubMed Google Scholar
Holler, E. et al. Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation. Blood 75, 1011–1016 (1990).
Article CAS PubMed Google Scholar
Storb, R. et al. Allogeneic hematopoietic cell transplantation following minimal intensity conditioning: predicting acute graft-versus-host disease and graft-versus-tumor effects. Biol. Blood Marrow Transplant. 19, 792–798 (2013).
Article CAS PubMed PubMed Central Google Scholar
Cooke, K. R., Olkiewicz, K., Erickson, N. & Ferrara, J. L. The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease. J. Endotoxin Res. 8, 441–448 (2002).
Article CAS PubMed Google Scholar
Holler, E. et al. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104, 889–894 (2004).
Article CAS PubMed Google Scholar
Holler, E. et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 107, 4189–4193 (2006).
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