Effect of brain endurance training on fatigue and physical endurance among stroke survivors: a non-blinded randomized controlled trial

1. Jones SP, Baqai K, Clegg A, et al. Stroke in India: a systematic review of the incidence, prevalence, and case fatality. Int J Stroke 2022;17:132-40. doi: 10.1177/17474930211027834.

2. Satapathy P, Shabil M, Khatib MN, et al. Association of cardiometabolic index and risk of stroke: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 2025;34:108337. doi: 10.1016/j.jstrokecerebrovasdis.2025.108337.

3. English C, Simpson DB, Billinger SA, et al. A roadmap for research in post-stroke fatigue: consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable. Neurorehabilitation and Neural Repair. Int J Stroke 2024;19:133-44. doi: 10.1177/17474930231189135.

4. Jagadish A, Natarajan M, Guddattu V, Solomon JM. Prevalence of poststroke fatigue and its relationship with clinical characteristics among community-dwelling stroke survivors: a cross-sectional survey. Clin Epidemiol Global Health 2024;30:101812. doi: 10.1016/j.cegh.2024.101812.

5. Aali G, Drummond A, das Nair R, Shokraneh F. Post-stroke fatigue: a scoping review. F1000Res 2020;9:242. doi: 10.12688/f1000research.22880.2.

6. Zeng H, Yang J, Wu J, et al. The impact of post-stroke fatigue on inpatient rehabilitation outcomes: an observational study. PloS One 2024;19:e0302574. doi: 10.1371/journal.pone.0302574.

7. Paciaroni M, Acciarresi M. Poststroke fatigue. Stroke 2019;50:1927-33. doi: 10.1161/STROKEAHA.119.023552.

8. Kuppuswamy A. Post‐stroke fatigue–a multidimensional problem or a cluster of disorders? A case for phenotyping post‐stroke fatigue. J Physiol 2025;603:759-72. doi: 10.1113/JP285900.

9. Kuppuswamy A, Billinger S, Coupland KG, et al. Mechanisms of post-stroke fatigue: a follow-up from the third stroke recovery and rehabilitation roundtable. Neurorehabil Neural Repair 2024;38:52-61. doi: 10.1177/15459683231219266

10. De Doncker W, Dantzer R, Ormstad H, Kuppuswamy A. Mechanisms of poststroke fatigue. J Neurol Neurosurg Psychiatry 2018;89:287-93. doi: 10.1136/jnnp-2017-316007.

11. Larsson P, Bidonde J, Olsen U et al. Association of post-stroke fatigue with physical activity and physical fitness: a systematic review and meta-analysis. Int J Stroke 2023;18:1063-70. doi: 10.1177/17474930231152132.

12. Dong Y, Badrin S, Badrin S, Tang L. Post-stroke fatigue interventions for stroke survivors: a scoping review. Belitung Nurs J 2024;10:601. doi: 10.33546/bnj.3526.

13. Rajendran V, Jeevanantham D. Effects of exercise and pharmacotherapy on fatigue in stroke patients: a systematic review with meta-analysis. Brain Disord 2025;19:100274. doi: 10.1016/j.dscb.2025.100274.

14. Anguera JA, Volponi JJ, Simon AJ et al. Integrated cognitive and physical fitness training enhances attention abilities in older adults. NPJ Aging 2022;8:12. doi: 10.1038/s41514-022-00093-y.

15. Rieker JA, Reales JM, Muiños M, Ballesteros S. The effects of combined cognitive-physical interventions on cognitive functioning in healthy older adults: a systematic review and multilevel meta-analysis. Front Human Neurosci 2022;16:838968. doi: 10.3389/fnhum.2022.838968.

16. Dallaway N, Lucas S, Marks J, Ring C. Prior brain endurance training improves endurance exercise performance. Eur J Sport Sci 2023;23:1269-78. doi: 10.1080/17461391.2022.2153231.

17. Van Cutsem J, Marcora S, De Pauw K, et al. The effects of mental fatigue on physical performance: a systematic review. Sports Med 2017;47:1569-88. doi: 10.1007/s40279-016-0672-0.

18. Roelands B, Bogataj Š. Optimizing athletic performance through brain endurance training. Int J Sports Physiol Perform 2024;19:973-4. doi: 10.1123/ijspp.2024-0278.

19. Dallaway N, Lucas SJ, Ring C. Concurrent brain endurance training improves endurance exercise performance. J Sci Med Sport 2021;24:405-11. doi: 10.1016/j.jsams.2020.10.008.

20. Amorós-Aguilar L, Rodríguez-Quiroga E, Sánchez-Santolaya S, Coll-Andreu M. Effects of combined interventions with aerobic physical exercise and cognitive training on cognitive function in stroke patients: a systematic review. Brain Sci 2021;11:473. doi: 10.3390/brainsci11040473.

21. Díaz-García J, García-Calvo T, Ring C. Brain endurance training improves sedentary older adults’ cognitive and physical performance when fresh and fatigued. Psycho Sport Exerc 2025;76:102757. doi: 10.1016/j.psychsport.2024.102757.

22. Ozyemisci-Taskiran O, Batur EB, Yuksel S, Cengiz M, Karatas GK. Validity and reliability of fatigue severity scale in stroke. Top Stroke Rehabil 2019;26:122-7. doi: 10.1080/10749357.2018.1550957.

23. Lerdal A. Fatigue severity scale. In: Maggino F. (editor) Encyclopedia of quality of life and well-being research. Springer, Cham;2021. pp. 1-5. https://doi.org/10.1007/978-3-319-69909-7_1018-3.

24. Cheng DK, Nelson M, Brooks D, Salbach NM. Validation of stroke-specific protocols for the 10-meter walk test and 6-minute walk test conducted using 15-meter and 30-meter walkways. Top Stroke Rehabil 2020;27:251-61. doi: 10.1080/10749357.2019.1691815.

25. Clague-Baker N, Robinson T, Hagenberg A, Drewry S, Gillies C, Singh S. The validity and reliability of the Incremental Shuttle Walk Test and Six-minute Walk Test compared to an Incremental Cycle Test for people who have had a mild-to-moderate stroke. Physiotherapy. 2019;105:275-82. doi: 10.1016/j.physio.2018.12.005.

26. Staiano W, Merlini M, Marcora S. A randomized controlled trial of brain endurance training (BET) to reduce fatigue during endurance exercise. In: ACSM Annual Meeting San Diego, USA; 2015. doi: 10.1249/01.mss.0000476967.03579.44.

27. Alahmari W, Alhowimel A, Alotaibi M, et al. Effects of physiotherapy interventions for poststroke fatigue: a systematic review. Stroke 2025;56:148-57. doi: 10.1161/STROKEAHA.123.046064.

28. Wang Q, Dai W, Xu S, et al. Brain activation of the PFC during dual-task walking in stroke patients: a systematic review and meta-analysis of functional near-infrared spectroscopy studies. Front Neurosc 2023;17:1111274. doi: 10.3389/fnins.2023.1111274.

29. Venugopal A, Subramanian SS, Sahal M, Bai P, GN J. Mirror therapy versus dual-task training on motor functions in MCA. Phys Rehab Recreational Health Technol 2025;10:300-7. doi: 10.15391/prrht.2025-10(4).08.

30. Maeneja R, Silva CR, Ferreira IS, Abreu AM. Aerobic physical exercise versus dual-task cognitive walking in cognitive rehabilitation of people with stroke: a randomized clinical trial. Front Psychol 2023;14:1258262. doi: 10.3389/fpsyg.2023.1258262.

31. Billinger SA, Mattlage AE, Ashenden AL, et al. Aerobic exercise in subacute stroke improves cardiovascular health and physical performance. J Neurol Phys Ther 2012;36:159-65. doi:10.1097/NPT.0b013e318274d082.

32. Ekici PE, Özkeskin PM, Yüceyar AN. Effects of dual-task training on balance, gait, dual-task performance, cognitive function, fatigue in individuals with multiple sclerosis: a randomized controlled trial: Dual-Task Training in MS. Mult Scler Relat Disord 2025;102:106645. doi: 10.1016/j.msard.2025.106645.

33. Farajnia S, Rajabi H, Ghaffari M, et al. The effects of dual-task training on inflammatory biomarkers, physical performance, fatigue, and quality of life in patients with multiple sclerosis. Mult Scler Relat Disord 2025;99:106412. doi: 10.1016/j.msard.2025.106412.

34. Jin Z, Zhu L, Zhou S, Lu C. Managing post-stroke fatigue using a mobile health called iHealth after intracerebral hemorrhage. J Multidisciplinary Healthcare 2024:2389-97. doi: 10.2147/JMDH.S465902.

35. Paul L, Wyke S, Brewster S, et al. Increasing physical activity in stroke survivors using STARFISH, an interactive mobile phone application: a pilot study. Top Stroke Rehabil 2016;23:170-7. doi: 10.1080/10749357.2015.1122266.

36. Srinivasan V, Umasankar Y, Murugaiyan P. Effect of gamification for hand grip, hand function and stress among patients with hemiparesis: a pilot study. Texila Int J Public Health 2025;25:3146. doi:10.21522/TIJPH.2013.SE.25.02.Art018.

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