Remember me
Abstract
The detection of atrial fibrillation (AF) after transient ischemic attacks (TIA) is crucial for initiating effective secondary prevention using oral anticoagulation. The choice of the best method and the duration of ECG monitoring to detect AF is uncertain. ODEA-TIA is a multicenter, investigator-initiated, randomized, open-label, blinded-endpoint clinical trial designed to compare three ECG monitoring strategies for detecting AF in patients aged 50 years or older who experienced a TIA within 28 days before randomization and had no prior history of AF. Participants are randomly assigned in a 1:1:1 ratio, stratified by age and center, to undergo either 24-hour Holter ECG, 28-day noninvasive continuous ECG patch monitoring, or continuous recording with a subcutaneously implantable loop recorder for up to 2-years. The primary endpoint is the rate of newly detected AF within 6 months after study enrolment. Secondary endpoints include AF detection at 12 and 24 months, and overall prevalence of AF during follow-up in long-term recordings. Exploratory analyses include clinical outcomes, initiation of anticoagulation, and performance parameters. A substudy investigates the usefulness of blood-based biomarkers to predict AF. ODEA-TIA aims to establish evidence-based ECG monitoring strategies for the detection of AF to improve secondary prevention in TIA patients.
Keywords transient ischemic attack - atrial fibrillation - ECG monitoring - implantable loop recorder - secondary stroke prevention Declaration of GenAI UseDuring the preparation of this work, the authors used OpenEvidence to assist with the literature research and to improve the clarity of the manuscript. Following its use, the authors thoroughly reviewed and edited the content as necessary and take full responsibility for the final version of the published manuscript.
‡ The details of ODEA-TIA investigators are mentioned in the [Supplementary Appendix] (available in the online version only).
Received: 03 December 2025
Accepted after revision: 12 March 2026
Accepted Manuscript online:
20 March 2026
Article published online:
01 April 2026
© 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Comments (0)