A Validated Transcriptomic NMJ Remodeling Score Reveals Synaptic Dysfunction Independent of Muscle Atrophy after Immobilization in a Microgravity Analog

Bodine, S. C., Latres, E., Baumhueter, S., et al. (2001). Identification of ubiquitin ligases required for skeletal muscle atrophy. Science, 294(5547), 1704–1708. https://doi.org/10.1126/science.1065874

Article  CAS  PubMed  Google Scholar 

Burden, Steven J., et al. (2018). Fundamental molecules and mechanisms for forming and maintaining neuromuscular synapses. International Journal of Molecular Sciences, 19(2), Article 490. https://doi.org/10.3390/ijms19020490

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campbell, E. L., Seynnes, O. R., Bottinelli, R., et al. (2013). Skeletal muscle adaptations to physical inactivity and subsequent retraining in young men. Biogerontology, 14(3), 247–259. https://doi.org/10.1007/s10522-013-9427-6

Article  CAS  PubMed  Google Scholar 

Carnio, S., LoVerso, F., Baraibar, M. A., et al. (2014). Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious aging. Cell Reports, 8(5), 1509–1521. https://doi.org/10.1016/j.celrep.2014.07.061

Article  CAS  PubMed  Google Scholar 

Clark, B. C., & Manini, T. M. (2010). Functional consequences of sarcopenia and dynapenia in the elderly. Current Opinion in Clinical Nutrition & Metabolic Care, 13(3), 271–276. https://doi.org/10.1097/MCO.0b013e328337819e

Article  Google Scholar 

Fitts, R. H., Trappe, S. W., Costill, D. L., et al. (2010). Prolonged space flight–induced alterations in the structure and function of human skeletal muscle fibres. The Journal of Physiology, 588(18), 3567–3592. https://doi.org/10.1113/jphysiol.2010.188508

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001). Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proceedings of the National Academy of Sciences, 98(25), 14440–14445. https://doi.org/10.1073/pnas.251541198

Article  CAS  Google Scholar 

Kumar, R., Sporn, K., Ong, J., Waisberg, E., Paladugu, P., Vaja, S., Hage, T., Sekhar, T. C., Vadhera, A. S., Ngo, A., et al. (2025). Integrating artificial intelligence in orthopedic care: Advancements in bone care and future directions. Bioengineering, 12(5), 513. https://doi.org/10.3390/bioengineering12050513

Article  PubMed  PubMed Central  Google Scholar 

Li, L., et al. (2018). Neuromuscular junction Formation, Aging, and disorders. Annual Review of Physiology, 80, 159–188. https://doi.org/10.1146/annurev-physiol-022516-034255

Article  CAS  PubMed  Google Scholar 

Rudolf, R., Khan, M. M., Labeit, S., & Deschenes, M. R. (2014). Degeneration of neuromuscular junction in age and dystrophy. Frontiers in Aging Neuroscience, 6, Article 99. https://doi.org/10.3389/fnagi.2014.00099

Article  PubMed  PubMed Central  Google Scholar 

Sandri, M. (2013). Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome. International Journal of Biochemistry & Cell Biology, 45(10), 2121–2129. https://doi.org/10.1016/j.biocel.2013.04.023

Article  CAS  Google Scholar 

Sanes, J. R., & Lichtman, J. W. (2001). Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nature reviews. Neuroscience, 2(11), 791–805. https://doi.org/10.1038/35097557

Article  CAS  PubMed  Google Scholar 

Sarto, F., Stashuk, D. W., Franchi, M. V., et al. (2022). Effects of short-term unloading and active recovery on human motor unit properties, neuromuscular junction transmission and transcriptomic profile. The Journal of Physiology, 600(20), 4731–4751. https://doi.org/10.1113/JP283381

Article  CAS  PubMed  Google Scholar 

Sirago, G., Conte, E., Fracasso, F., et al. (2017). Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia. Scientific Reports, 7(1), Article 13017. https://doi.org/10.1038/s41598-017-13504-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tintignac, Lionel A., et al. (2015). Mechanisms regulating neuromuscular junction development and function and causes of muscle wasting. Physiological Reviews, 95(3), 809. https://doi.org/10.1152/physrev.00033.2014

Article  CAS  PubMed  Google Scholar 

Trappe, S., Trappe, T., Gallagher, P., Harber, M., Alkner, B., & Tesch, P. (2004). Human single muscle fibre function with 84 day bed-rest and resistance exercise. The Journal of Physiology, 557(2), 501–513. https://doi.org/10.1113/jphysiol.2004.062166

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif