Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

PubMed  Google Scholar 

Muller L, Kloeckner R, Mahringer-Kunz A, et al. Fully automated AI-based Splenic segmentation for predicting survival and estimating the risk of hepatic decompensation in TACE patients with HCC. Eur Radiol. 2022;32:6302–13.

Article  PubMed  PubMed Central  Google Scholar 

Prince DS, Schlaphoff G, Davison SA, et al. Selective internal radiation therapy for hepatocellular carcinoma: A 15-year multicenter Australian cohort study. J Gastroenterol Hepatol. 2022;37:2173–81.

Article  PubMed  Google Scholar 

Llovet JM, Zucman-Rossi J, Pikarsky E, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2016;2:16018.

Article  PubMed  Google Scholar 

Huang DQ, Singal AG, Kanwal F, et al. Hepatocellular carcinoma surveillance - utilization, barriers and the impact of changing aetiology. Nat Rev Gastroenterol Hepatol. 2023;20:797–809.

Article  PubMed  Google Scholar 

Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16:589–604.

Article  PubMed  PubMed Central  Google Scholar 

European Association for the Study of the Liver. Electronic address eee, European association for the study of the L. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236.

Article  Google Scholar 

Kennedy A, Brown DB, Feilchenfeldt J, et al. Safety of selective internal radiation therapy (SIRT) with yttrium-90 microspheres combined with systemic anticancer agents: expert consensus. J Gastrointest Oncol. 2017;8:1079–99.

Article  PubMed  PubMed Central  Google Scholar 

Inarrairaegui M, Martinez-Cuesta A, Rodriguez M, et al. Analysis of prognostic factors after yttrium-90 radioembolization of advanced hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2010;77:1441–8.

Article  PubMed  Google Scholar 

Kulik LM, Carr BI, Mulcahy MF, et al. Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis. Hepatology. 2008;47:71–81.

Article  PubMed  Google Scholar 

Salem R, Lewandowski RJ, Mulcahy MF, et al. Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: a comprehensive report of long-term outcomes. Gastroenterology. 2010;138:52–64.

Article  PubMed  CAS  Google Scholar 

Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115:209–18.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sangro B, Inarrairaegui M, Bilbao JI. Radioembolization for hepatocellular carcinoma. J Hepatol. 2012;56:464–73.

Article  PubMed  Google Scholar 

Fernandez-Ros N, Silva N, Bilbao JI, et al. Partial liver volume radioembolization induces hypertrophy in the spared hemiliver and no major signs of portal hypertension. HPB (Oxford). 2014;16:243–9.

Article  PubMed  Google Scholar 

Jakobs TF, Saleem S, Atassi B, et al. Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90yttrium microspheres. Dig Dis Sci. 2008;53:2556–63.

Article  PubMed  CAS  Google Scholar 

Fernandez-Ros N, Inarrairaegui M, Paramo JA, et al. Radioembolization of hepatocellular carcinoma activates liver regeneration, induces inflammation and endothelial stress and activates coagulation. Liver Int. 2015;35:1590–6.

Article  PubMed  CAS  Google Scholar 

Bae JS, Lee DH, Yoo J, et al. Association between spleen volume and the post-hepatectomy liver failure and overall survival of patients with hepatocellular carcinoma after resection. Eur Radiol. 2021;31:2461–71.

Article  PubMed  Google Scholar 

Wu WC, Chiou YY, Hung HH, et al. Prognostic significance of computed tomography scan-derived Splenic volume in hepatocellular carcinoma treated with radiofrequency ablation. J Clin Gastroenterol. 2012;46:789–95.

Article  PubMed  CAS  Google Scholar 

Chen XL, Chen TW, Zhang XM, et al. Platelet count combined with right liver volume and spleen volume measured by magnetic resonance imaging for identifying cirrhosis and esophageal varices. World J Gastroenterol. 2015;21:10184–91.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu P, Li P, He W, Zhao LQ. Liver and spleen volume variations in patients with hepatic fibrosis. World J Gastroenterol. 2009;15:3298–302.

Article  PubMed  PubMed Central  Google Scholar 

Yan SP, Wu H, Wang GC, Chen Y, Zhang CQ, Zhu Q. A new model combining the liver/spleen volume ratio and classification of varices predicts HVPG in hepatitis B patients with cirrhosis. Eur J Gastroenterol Hepatol. 2015;27:335–43.

Article  PubMed  Google Scholar 

Nuffer Z, Marini T, Rupasov A, Kwak S, Bhatt S. The best single measurement for assessing splenomegaly in patients with cirrhotic liver morphology. Acad Radiol. 2017;24:1510–6.

Article  PubMed  Google Scholar 

Hosny A, Parmar C, Quackenbush J, Schwartz LH, Aerts H. Artificial intelligence in radiology. Nat Rev Cancer. 2018;18:500–10.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bruix J, Sherman M, Llovet JM et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. 2001;35:421–430.

Bruix J, Sherman M, Practice Guidelines Committee AAftSoLD. Management of hepatocellular carcinoma. Hepatology. 2005;42:1208–36.

Article  PubMed  Google Scholar 

Llovet JM, Di Bisceglie AM, Bruix J, et al. Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst. 2008;100:698–711.

Article  PubMed  Google Scholar 

Golfieri R, Mosconi C, Cappelli A, et al. Efficacy of radioembolization according to tumor morphology and portal vein thrombosis in intermediate-advanced hepatocellular carcinoma. Future Oncol. 2015;11:3133–42.

Article  PubMed  CAS  Google Scholar 

Gramenzi A, Golfieri R, Mosconi C, et al. Yttrium-90 radioembolization vs Sorafenib for intermediate-locally advanced hepatocellular carcinoma: a cohort study with propensity score analysis. Liver Int. 2015;35:1036–47.

Article  PubMed  CAS  Google Scholar 

Wasserthal J, Breit HC, Meyer MT, et al. TotalSegmentator: robust segmentation of 104 anatomic structures in CT images. Radiol Artif Intell. 2023;5:e230024.

Article  PubMed  PubMed Central  Google Scholar 

Weber M, Lam M, Chiesa C, et al. EANM procedure guideline for the treatment of liver cancer and liver metastases with intra-arterial radioactive compounds. Eur J Nucl Med Mol Imaging. 2022;49:1682–99.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994; 81(3):515–526.

Jin Y, Ren H, Yue Q, et al. Surrogacy of one-year survival for overall survival in advanced hepatocellular carcinoma. BMC Cancer. 2024;24:258.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Villanueva A. Hepatocellular carcinoma. N Engl J Med. 2019;380:1450–62.

Article  PubMed  CAS  Google Scholar 

Pinato DJ, Sharma R, Allara E, et al. The ALBI grade provides objective hepatic reserve Estimation across each BCLC stage of hepatocellular carcinoma. J Hepatol. 2017;66:338–46.

Article  PubMed  Google Scholar 

Mosconi C, Gramenzi A, Ascanio S, et al. Yttrium-90 radioembolization for unresectable/recurrent intrahepatic cholangiocarcinoma: a survival, efficacy and safety study. Br J Cancer. 2016;115:297–302.

Article