Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33. https://doi.org/10.3322/caac.21708.

Article  PubMed  Google Scholar 

Zheng R, Zhang S, Zeng H, Wang S, Sun K, Chen R, et al. Cancer incidence and mortality in China, 2016. J Natl Cancer Cent. 2022;2:1–9. https://doi.org/10.1016/j.jncc.2022.02.002.

Article  PubMed  PubMed Central  Google Scholar 

Yuan C, Chen H, Tu S, Huang HY, Pan Y, Gui X, et al. A systematic dissection of the epigenomic heterogeneity of lung adenocarcinoma reveals two different subclasses with distinct prognosis and core regulatory networks. Genome Biol. 2021;22:156. https://doi.org/10.1186/s13059-021-02376-1.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Atkins NK, Marjara J, Kaifi JT, Kunin JR, Saboo SS, Davis RM, et al. Role of computed tomography-guided biopsies in the era of electromagnetic navigational bronchoscopy: A retrospective study of factors predicting diagnostic yield in electromagnetic navigational bronchoscopy and computed tomography biopsies. J Clin Imaging Sci. 2020;10. https://doi.org/10.25259/JCIS_53_2020.

Richmond J, Fernandez JR, Bonnet K, Sellers A, Schlundt DG, Forde AT, et al. Patient lung cancer screening decisions and environmental and psychosocial factors. JAMA Netw Open. 2024;7:e2412880. https://doi.org/10.1001/jamanetworkopen.2024.12880.

Article  PubMed  PubMed Central  Google Scholar 

Groheux D, Quere G, Blanc E, Lemarignier C, Vercellino L, de Margerie-Mellon C, et al. FDG PET-CT for solitary pulmonary nodule and lung cancer: literature review. Diagn Interv Imaging. 2016;97:1003–17. https://doi.org/10.1016/j.diii.2016.06.020.

Article  PubMed  CAS  Google Scholar 

Mabuchi S, Komura N, Sasano T, Shimura K, Yokoi E, Kozasa K, et al. Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies. Nat Commun. 2020;11:1364. https://doi.org/10.1038/s41467-020-15186-z.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang R, Jakobsson V, Wang J, Zhao T, Peng X, Li B, et al. Dual targeting PET tracer [68Ga]Ga-FAPI-RGD in patients with lung neoplasms: a pilot exploratory study. Theranostics. 2023;13:2979–92. https://doi.org/10.7150/thno.86007.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Peltanova B, Raudenska M, Masarik M. Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review. Mol Cancer. 2019;18:63. https://doi.org/10.1186/s12943-019-0983-5.

Article  PubMed  PubMed Central  Google Scholar 

Wang L, Pan X, Ye S, Huang Y, Wang M, Chen L, et al. [18F]F-FAPI-42 PET dynamic imaging characteristics and multiparametric quantification of lung cancer: an exploratory study using uEXPLORER PET/CT. Eur J Nucl Med Mol Imaging. 2025;52:1685–94. https://doi.org/10.1007/s00259-024-07064-3.

Article  PubMed  CAS  Google Scholar 

Hou G, Cheng X, Jiang Y, Yang Y, Chen B, Huang Z, et al. Comparison of al 18F-NOTA-FAPI-74 and 18F-FDG PET/CT in the evaluation and staging of hepatobiliary malignancies: A Single-center prospective study. Clin Nucl Med. 2025;50:612–22. https://doi.org/10.1097/RLU.0000000000005889.

Article  PubMed  Google Scholar 

Bian L, Liu X, Wang X, Sun Y, Du X, Gu B, et al. Preclinical and First-In-Human imaging of novel [18F]F-FAPI-FUSCC-07 tracer: comparative prospective study with [18F]F-FAPI-42 and [18F]F-FAPI-74. Mol Pharm. 2025;22:1624–32. https://doi.org/10.1021/acs.molpharmaceut.4c01360.

Article  PubMed  CAS  Google Scholar 

Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, et al. The 2021 WHO classification of lung tumors: impact of advances since 2015. J Thorac Oncol. 2021. https://doi.org/10.1016/j.jtho.2021.11.003.

Article  PubMed  PubMed Central  Google Scholar 

Yan J, Bhadane R, Ran M, Ma X, Li Y, Zheng D, et al. Development of Aptamer-DNAzyme based metal-nucleic acid frameworks for gastric cancer therapy. Nat Commun. 2024;15:3684. https://doi.org/10.1038/s41467-024-48149-9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bankier AA, MacMahon H, Colby T, Gevenois PA, Goo JM, Leung ANC, et al. Fleischner society: glossary of terms for thoracic imaging. Radiology. 2024;310:e232558. https://doi.org/10.1148/radiol.232558.

Article  PubMed  PubMed Central  Google Scholar 

Du X, Gu B, Wang X, Wang X, Ji M, Zhang J, et al. Preclinical evaluation and a pilot clinical positron emission tomography imaging study of [68Ga]Ga-FAPI-FUSCC-II. Mol Pharm. 2024;21:904–15. https://doi.org/10.1021/acs.molpharmaceut.3c01008.

Article  PubMed  CAS  Google Scholar 

Watabe T, Naka S, Tatsumi M, Kamiya T, Kimura T, Shintani Y, et al. Initial evaluation of [18F]FAPI-74 PET for various histopathologically confirmed cancers and benign lesions. J Nucl Med. 2023;64:1225–31. https://doi.org/10.2967/jnumed.123.265486.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ahenkorah S, Murce E, Cawthorne C, Ketchemen JP, Deroose CM, Cardinaels T, et al. 3p-C-NETA: A versatile and effective chelator for development of Al(18)F-labeled and therapeutic radiopharmaceuticals. Theranostics. 2022;12:5971–85. https://doi.org/10.7150/thno.75336.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sanchez-Crespo A. Comparison of Gallium-68 and Fluorine-18 imaging characteristics in positron emission tomography. Appl Radiat Isot. 2013;76:55–62. https://doi.org/10.1016/j.apradiso.2012.06.034.

Article  PubMed  CAS  Google Scholar 

Beaino W, Anderson CJ. PET imaging of very late antigen-4 in melanoma: comparison of 68Ga- and 64Cu-labeled NODAGA and CB-TE1A1P-LLP2A conjugates. J Nucl Med. 2014;55:1856–63. https://doi.org/10.2967/jnumed.114.144881.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wessendorf J, Spektor AM, Aboulmaouahib B, Daum J, Glatting FM, Schlamp K, et al. Image analysis: 68Ga-FAPI-46 PET derived texture parameters improve the differentiation of malignant and benign pulmonary lesions. Cancer Imaging. 2025;25:73. https://doi.org/10.1186/s40644-025-00886-w.

Article  PubMed  PubMed Central  Google Scholar 

Mu X, Zhu Z, Wang Z, Li X, Wu Y, Li J, et al. Insights into lung cancer diagnosis and clinical management using [18F]F-fibroblast activation protein inhibitor (FAPI)-42 positron emission tomography/computed tomography (PET/CT). Ann Nucl Med. 2025;39:576–87. https://doi.org/10.1007/s12149-025-02032-9.

Article  PubMed  CAS  Google Scholar 

Qin J, Yu J, Wei Y. Comparison of Al[18F]-NOTA-FAPI-04 PET/CT and [18F]-FDG PET/CT in a patient with lung cancer and pulmonary tuberculosis: a case report and literature review. Front Oncol. 2025;15:1470132. https://doi.org/10.3389/fonc.2025.1470132.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou X, Wang S, Xu X, Meng X, Zhang H, Zhang A, et al. Higher accuracy of [68Ga]Ga-DOTA-FAPI-04 PET/CT comparing with 2-[18F]FDG PET/CT in clinical staging of NSCLC. Eur J Nucl Med Mol Imaging. 2022;49:2983–93. https://doi.org/10.1007/s00259-022-05818-5.

Article  PubMed  CAS  Google Scholar 

Kang YK, Na KJ, Park J, Kwak N, Lee YS, Choi H, et al. Preoperative evaluation of mediastinal lymph nodes in non-small cell lung cancer using [68Ga]FAPI-46 PET/CT: a prospective pilot study. Eur J Nucl Med Mol Imaging. 2024;51:2409–19. https://doi.org/10.1007/s00259-024-06669-y.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yu M, Wang Z, Yang G, Cheng Y. A model of malignant risk prediction for solitary pulmonary nodules on 18F-FDG PET/CT: Building and estimating. Thorac Cancer. 2020;11:1211–5. https://doi.org/10.1111/1759-7714.13375.

Article  PubMed  PubMed Central  Google Scholar 

Jia J, Zhang G, Wei L, Qi L, Wang X, Li L, et al. The battle for accuracy: identifying the most effective grading system for lung invasive mucinous adenocarcinoma. Ann Surg Oncol. 2024;31:5717–28. https://doi.org/10.1245/s10434-024-15541-0.