Gadelha M, Gatto F, Wildemberg LE, Fleseriu M. Cushing’s syndrome. Lancet. 2023;402:2237–52. https://doi.org/10.1016/S0140-6736(23)01961-X.
Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, et al. Consensus on diagnosis and management of Cushing’s disease: a guideline update. Lancet Diabetes Endocrinol. 2021;9:847–75. https://doi.org/10.1016/S2213-8587(21)00235-7.
Article PubMed PubMed Central Google Scholar
Giuffrida G, Crisafulli S, Ferrau F, Fontana A, Alessi Y, Calapai F, et al. Global Cushing’s disease epidemiology: a systematic review and meta-analysis of observational studies. J Endocrinol Invest. 2022;45:1235–46. https://doi.org/10.1007/s40618-022-01754-1.
Article PubMed CAS Google Scholar
Reincke M, Fleseriu M, Cushing Syndrome. Rev JAMA. 2023;330:170–81. https://doi.org/10.1001/jama.2023.11305.
Nieman LK, Castinetti F, Newell-Price J, Valassi E, Drouin J, Takahashi Y, et al. Cushing syndrome. Nat Rev Dis Primers. 2025;11:4. https://doi.org/10.1038/s41572-024-00588-w.
Ding J, Tong A, Hacker M, Feng M, Huo L, Li X. Usefulness of 68 Ga-Pentixafor PET/CT on Diagnosis and Management of Cushing Syndrome. Clin Nucl Med. 2022;47:669–76. https://doi.org/10.1097/RLU.0000000000004244.
Wu Y, Wu Y, Yao B, Ren S, Wu S, Rui W, et al. Diagnostic Accuracy and Value of CXCR4-targeted PET/MRI Using (68)Ga-Pentixafor for Tumor Localization in Cushing Disease. Radiology. 2024;313:e233469. https://doi.org/10.1148/radiol.233469.
Horiguchi K, Ilmiawati C, Fujiwara K, Tsukada T, Kikuchi M, Yashiro T. Expression of chemokine CXCL12 and its receptor CXCR4 in folliculostellate (FS) cells of the rat anterior pituitary gland: the CXCL12/CXCR4 axis induces interconnection of FS cells. Endocrinology. 2012;153:1717–24. https://doi.org/10.1210/en.2011-1937.
Article PubMed CAS Google Scholar
Xing B, Kong YG, Yao Y, Lian W, Wang RZ, Ren ZY. Study on the expression levels of CXCR4, CXCL12, CD44, and CD147 and their potential correlation with invasive behaviors of pituitary adenomas. Biomed Environ Sci: BES. 2013;26:592–8. https://doi.org/10.3967/0895-3988.2013.07.011.
Article PubMed CAS Google Scholar
Barbieri F, Thellung S, Würth R, Gatto F, Corsaro A, Villa V, et al. Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System. Int J Endocrinol. 2014;2014:753524. https://doi.org/10.1155/2014/753524.
Article PubMed PubMed Central Google Scholar
Bonneville JF, Potorac I, Petrossians P, Tshibanda L, Beckers A. Pituitary MRI in Cushing’s disease - an update. J Neuroendocrinol. 2022;34:e13123. https://doi.org/10.1111/jne.13123.
Article PubMed CAS Google Scholar
Team RC. R: A Language and Environment for Statistical Computing. Vienna, Austria.: R Foundation for Statistical Computing; 2024.
Ehman EC, Johnson GB, Villanueva-Meyer JE, Cha S, Leynes AP, Larson PEZ, et al. PET/MRI: Where might it replace PET/CT? J Magn Reson Imaging. 2017;46:1247–62. https://doi.org/10.1002/jmri.25711.
Article PubMed PubMed Central Google Scholar
Xiong W, Gao X, Zhang T, Jiang B, Hu MM, Bu X, et al. USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy. Nat Commun. 2022;13:1700. https://doi.org/10.1038/s41467-022-29401-6.
Article PubMed PubMed Central CAS Google Scholar
Tang J, Long G, Hu K, Xiao D, Liu S, Xiao L, et al. Targeting USP8 Inhibits O-GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT. Adv Sci (Weinh). 2023;10:e2302953. https://doi.org/10.1002/advs.202302953.
Article PubMed PubMed Central CAS Google Scholar
Peng H, Yang F, Hu Q, Sun J, Peng C, Zhao Y, et al. The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity. Autophagy. 2020;16:698–708. https://doi.org/10.1080/15548627.2019.1635381.
Article PubMed CAS Google Scholar
Florio T, Casagrande S, Diana F, Bajetto A, Porcile C, Zona G, et al. Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals. Mol Pharmacol. 2006;69:539–46. https://doi.org/10.1124/mol.105.015255.
Article PubMed CAS Google Scholar
Lee Y, Kim JM, Lee EJ. Functional expression of CXCR4 in somatotrophs: CXCL12 activates GH gene, GH production and secretion, and cellular proliferation. J Endocrinol. 2008;199:191–9. https://doi.org/10.1677/joe-08-0250.
Article PubMed CAS Google Scholar
Ma ZY, Song ZJ, Chen JH, Wang YF, Li SQ, Zhou LF, et al. Recurrent gain-of-function USP8 mutations in Cushing’s disease. Cell Res. 2015;25:306–17. https://doi.org/10.1038/cr.2015.20.
Article PubMed PubMed Central CAS Google Scholar
Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, et al. Mutations in the deubiquitinase gene USP8 cause Cushing’s disease. Nat Genet. 2015;47:31–8. https://doi.org/10.1038/ng.3166.
Article PubMed CAS Google Scholar
Perez-Rivas LG, von Selzam V, Sharma P, Reincke M, Theodoropoulou M. Prevalence and clinical associations of USP8 variants in corticotroph tumours: a systematic review and aggregate data meta-analysis of 2171 cases. Eur J Endocrinol. 2025;192:S41–52. https://doi.org/10.1093/ejendo/lvaf097.
Article PubMed CAS Google Scholar
Sbiera S, Kunz M, Weigand I, Deutschbein T, Dandekar T, Fassnacht M. The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the Spotlight. Cancers (Basel). 2019;11. https://doi.org/10.3390/cancers11111761.
Miao H, Liu Y, Lu L, Gong F, Wang L, Duan L, et al. Effect of 3 NR3C1 Mutations in the Pathogenesis of Pituitary ACTH Adenoma. Endocrinology. 2021;162. https://doi.org/10.1210/endocr/bqab167.
Perez-Rivas LG, Simon J, Albani A, Tang S, Roeber S, Assie G, et al. TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome. Acta Neuropathol Commun. 2022;10:139. https://doi.org/10.1186/s40478-022-01437-1.
Article PubMed PubMed Central CAS Google Scholar
Sbiera S, Perez-Rivas LG, Taranets L, Weigand I, Flitsch J, Graf E, et al. Driver mutations in USP8 wild-type Cushing’s disease. Neuro Oncol. 2019;21:1273–83. https://doi.org/10.1093/neuonc/noz109.
Article PubMed PubMed Central CAS Google Scholar
Simon J, Theodoropoulou M. Genetics of Cushing’s disease. J Neuroendocrinol. 2022;34:e13148. https://doi.org/10.1111/jne.13148.
Article PubMed CAS Google Scholar
Zheng Y, Long T, Peng N, Zhen M, Ye Q, Zhang Z, et al. The Value of Targeting CXCR4 With 68Ga-Pentixafor PET/CT for Subtyping Primary Aldosteronism. J Clin Endocrinol Metab. 2023;109:171–82. https://doi.org/10.1210/clinem/dgad421.
Article PubMed CAS Google Scholar
Hu J, Xu T, Shen H, Song Y, Yang J, Zhang A, et al. Accuracy of Gallium-68 Pentixafor Positron Emission Tomography-Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism. JAMA Netw open. 2023;6:e2255609. https://doi.org/10.1001/jamanetworkopen.2022.55609.
Article PubMed PubMed Central Google Scholar
Zheng WC, Chen SM, Qiu QR, Li XD, Lin F, Shen XM, et al. Total or partial adrenalectomy for aldosterone-producing adenoma: can (68)Ga-Pentixafor PET/CT predict surgical outcomes? Eur J Nucl Med Mol Imaging. 2025;52:3632–42. https://doi.org/10.1007/s00259-025-07244-9.
Ding J, Tong A, Zhang Y, Wen J, Zhang H, Hacker M, et al. Functional Characterization of Adrenocortical Masses in Nononcologic Patients Using (68)Ga-Pentixafor. Journal of nuclear medicine: official publication. Soc Nuclear Med. 2022;63:368–75. https://doi.org/10.2967/jnumed.121.261964.
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