Comparative Study of Obstetric Outcome in In Vitro Fertilization Pregnancies Following Fresh Versus Frozen Embryo Transfer

Manimekalai K, Poulpunitha S, Veeramani P. Infertility: an alarming situation in India. Int J Sci Technol Res. 2020;9(2):2606–9.

Google Scholar 

Mainigi M, Rosenzweig JM, Lei J, et al. Peri-implantation hormonal milieu: elucidating mechanisms of adverse neurodevelopmental outcomes. Reprod Sci. 2016;23(6):785–94. https://doi.org/10.1177/1933719115618280.

Article  CAS  PubMed  Google Scholar 

Roque M, Valle M, Sampaio M, et al. Obstetric outcomes after fresh versus frozen-thawed embryo transfers: a systematic review and meta-analysis. JBRA Assist Reprod. 2018;22(3):253–60. https://doi.org/10.5935/1518-0557.20180049.

Article  PubMed  PubMed Central  Google Scholar 

Spijkers S, Lens JW, Schats R, et al.. Fresh and frozen-thawed embryo transfer compared to natural conception: differences in perinatal outcome. Gynecol Obstet Invest. 2017;82:538–46.

Article  PubMed  Google Scholar 

Fattahpour SF, Hakimi P, Tabatabaei F, et al. Comparison of live birth rate and fetal outcomes between fresh embryo and frozen-thawed embryo transfers: a prospective study. BMC Pregnancy Childbirth. 2025;25(1):122. https://doi.org/10.1186/s12884-025-07247-2.

Article  PubMed  PubMed Central  Google Scholar 

Seshadri JG, Balani V, Kempaiah SB. Fetomaternal complications of in vitro fertilization pregnancies in a tertiary center. Int J Infertility Fetal Med. 2022;13(3):116–20.

Article  Google Scholar 

Chen Y, Zhou J, Chen Y, et al. Pregnancy outcomes after frozen embryo transfer and fresh embryo transfer in women of advanced maternal age: single-center experience. J Clin Med. 2022;11(21):6395. https://doi.org/10.3390/jcm11216395.

Article  PubMed  PubMed Central  Google Scholar 

Gullo G, Basile G, Cucinella G, et al. Fresh vs. frozen embryo transfer in assisted reproductive techniques: a single center retrospective cohort study and ethical-legal implications. Eur Rev Med Pharmacol Sci. 2023;27(14):6809–23. https://doi.org/10.26355/eurrev_202307_33152.

Article  CAS  PubMed  Google Scholar 

Zhang B, Wei D, Legro RS, et al. Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome: results from a randomized trial. Fertil Steril. 2018;109(2):324–9. https://doi.org/10.1016/j.fertnstert.2017.10.020.

Article  PubMed  Google Scholar 

Adamson GD, Norman RJ. Why are multiple pregnancy rates and single embryo transfer rates so different globally, and what do we do about it? Fertil Steril. 2020;114(4):680–9. https://doi.org/10.1016/j.fertnstert.2020.09.003.

Article  PubMed  Google Scholar 

Anitha A, Rani BS. Comparison of fresh and frozen thawed embryo transfer in terms of clinical pregnancy rate. Int J Reprod Contracept Obstet Gynecol. 2020;9(2):607–12. https://doi.org/10.18203/2320-1770.ijrcog20200345.

Article  Google Scholar 

Kathpalia SK, Kapoor K, Sharma A. Complications in pregnancies after in vitro fertilization and embryo transfer. Med J Armed Forces India. 2016;72(3):211–4. https://doi.org/10.1016/j.mjafi.2015.11.010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aflatoonian A, Karimzadeh Maybodi MA, Aflatoonian N, et al. Perinatal outcome in fresh versus frozen embryo transfer in ART cycles. Int J Reprod BioMed. 2016;14(3):167–72.

PubMed  PubMed Central  Google Scholar 

Sha T, Yin X, Cheng W, et al. Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis. Fertil Steril. 2018;109(2):330-342.e9. https://doi.org/10.1016/j.fertnstert.2017.10.019.

Article  PubMed  Google Scholar 

Zargar M, Dehdashti S, Najafian M, et al. Pregnancy outcomes following in vitro fertilization using fresh or frozen embryo transfer. JBRA Assist Reprod. 2021;25(4):570–4. https://doi.org/10.5935/1518-0557.20210024.

Article  PubMed  PubMed Central  Google Scholar 

Shoukry A, ElKassar Y, Hammad M, et al. Obstetric and perinatal outcomes after fresh embryo transfer versus frozen-thawed embryo transfer with artificial hormonal endometrial preparation: a prospective non-randomized study. Evid Based Women’s Health J. 2024;14(4):447–54. https://doi.org/10.21608/ebwhj.2024.301289.1338.

Article  Google Scholar 

Schwarze JE, Crosby JA, Zegers-Hochschild F. Effect of embryo freezing on perinatal outcome after assisted reproduction techniques: lessons from the Latin American Registry of Assisted Reproduction. Reprod Biomed Online. 2015;31:39–43. https://doi.org/10.1016/j.rbmo.2015.03.006.

Article  PubMed  Google Scholar 

Al-Khatib A, Sagot P, Cottenet J, et al. Major postpartum haemorrhage after frozen embryo transfer: a population-based study. BJOG. 2024;131(3):300–8. https://doi.org/10.1111/1471-0528.17625.

Article  CAS  PubMed  Google Scholar 

Yu H, Zhang Y, Han M. Comparison of Clinical pregnancy outcomes after fresh and frozen Embryo transfer. Comput Math Methods Med. 2022;2022:6.

Article  Google Scholar 

Boerwinkle CH, Tolcher MC, Hoff HS, et al. 768: Fresh versus frozen embryo transfer and obstetric and neonatal outcomes. Am J Obstet Gynecol. 2018;218(1):S459–60. https://doi.org/10.1016/j.ajog.2017.11.300.

Article  Google Scholar 

Petersen S, Westvik-Johari K, Spangmose AL, et al. Risk of hypertensive disorders in pregnancy after fresh and frozen embryo transfer in assisted reproduction: a population-based cohort study with within-sibship analysis. Hypertension. 2023;80(2):e6–16. https://doi.org/10.1161/HYPERTENSIONAHA.122.19689.

Article  CAS  Google Scholar 

Ernstad EG, Spangmose AL, Opdahl S, et al. Perinatal and maternal outcome after vitrification of blastocysts: a Nordic study in singletons from the CoNARTaS group. Hum Reprod Oxf Engl. 2019;34:2282–9. https://doi.org/10.1093/humrep/dez212.

Article  Google Scholar 

Stormlund S, Sopa N, Zedeler A, et al. Freeze-all versus fresh blastocyst transfer strategy during in vitro fertilisation in women with regular menstrual cycles: Multicentre randomised controlled trial. BMJ. 2020;370:m2519. https://doi.org/10.1136/bmj.m2519.

Article  PubMed  PubMed Central  Google Scholar 

Maheshwari A, Bari V, Bell JL, B et al. Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze, R.C.T. Health Technol Assess. 2022;26:1–142. https://doi.org/10.3310/AEFU1104.

Article  PubMed  PubMed Central  Google Scholar 

Cavoretto PI, Farina A, Gaeta G, et al. Greater estimated fetal weight and birth weight in IVF/ICSI pregnancy after frozen–thawed vs fresh blastocyst transfer: prospective cohort study with novel unified modeling methodology. Ultrasound Obstet Gynecol. 2022;60:76–85. https://doi.org/10.1002/uog.24806.

Article  CAS  PubMed  Google Scholar 

Shavit T, Oron G, Weon-Young S, et al. Vitrified-warmed single-embryo transfers may be associated with increased maternal complications compared with fresh single-embryo transfers. Reprod Biomed Online. 2017;35:94–102. https://doi.org/10.1016/j.rbmo.2017.03.016.

Article  PubMed  Google Scholar 

Hwang SS, Dukhovny D, Gopal D, et al. Health outcomes for Massachusetts infants after fresh versus frozen embryo transfer. Fertil Steril. 2019;112:900–7. https://doi.org/10.1016/j.fertnstert.2019.07.010.

Article  PubMed  PubMed Central  Google Scholar 

Hsiao YY, Chen CM, Chen YC, et al. High birth weight greater gestational age at birth in singletons born after frozen compared to fresh embryo transfer Taiwan. J Obstet Gynaecol. 2023;62:59–65. https://doi.org/10.1016/j.tjog.2022.06.017.

Article  Google Scholar 

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