Turner syndrome (TS) is characterized by partial or complete loss of one sex chromosome in females and is often associated with infertility due to gonadal dysgenesis.

We report a case of a 29-year-old mosaic TS (45,X/46,XX) woman who conceived following oocyte donation and multiple cycles of hormone replacement therapy with adjuvant endometrial interventions. Despite initial failed cycles due to recurrent intrauterine fluid collections and thin endometrium, optimized endometrial preparation with estradiol, filgrastim, and progesterone support led to successful implantation. She has achieved an ongoing singleton intrauterine pregnancy with uneventful antenatal course to date. This case highlights the challenges and strategies in managing infertility in Turner syndrome patients.