Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496(7446):445–55. https://doi.org/10.1038/nature12034.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11(11):723–37. https://doi.org/10.1038/nri3073.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weng X, Zhang Y, Li Z, Yu L, Xu F, Fang M, et al. Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1. Biochimica et Biophysica Acta (BBA). 2019;1862(2):163–72. https://doi.org/10.1016/j.bbagrm.2019.01.005.

Article  CAS  Google Scholar 

Bou Nasser Eddine F, Forlani G, Lombardo L, Tedeschi A, Tosi G, Accolla RS. CIITA-driven MHC class II expressing tumor cells can efficiently prime naive CD4(+) TH cells in vivo and vaccinate the host against parental MHC-II-negative tumor cells. Oncoimmunology. 2017;6(1):e1261777. https://doi.org/10.1080/2162402x.2016.1261777.

Article  PubMed  Google Scholar 

Romagnani S. Th1/Th2 Cells. Inflamm Bowel Dis. 1999;5(4):285–94. https://doi.org/10.1097/00054725-199911000-00009.

Article  CAS  PubMed  Google Scholar 

Foulds KE, Wu CY, Seder RA. Th1 memory: implications for vaccine development. Immunol Rev. 2006;211:58–66. https://doi.org/10.1111/j.0105-2896.2006.00400.x.

Article  CAS  PubMed  Google Scholar 

Zhu Z, He L, Bai Y, Xia L, Sun X, Qi C. Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer. Clin Exp Immunol. 2023;214(1):50–60. https://doi.org/10.1093/cei/uxad080.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He L, Zhu Z, Qi C. β-glucan—A promising immunocyte-targeting drug delivery vehicle: Superiority, applications and future prospects. Carbohydr Polym. 2024;122252. https://doi.org/10.1016/j.carbpol.2024.122252.

Qi C, Cai Y, Gunn L, Ding C, Li B, Kloecker G, et al. Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived β-glucans. Blood. 2011;117(25):6825–36. https://doi.org/10.1182/blood-2011-02-339812.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noorbakhsh Varnosfaderani SM, Ebrahimzadeh F, Akbari Oryani M, Khalili S, Almasi F, Mosaddeghi Heris R, et al. Potential promising anticancer applications of β-glucans: a review. Biosci Rep. 2024. https://doi.org/10.1042/BSR20231686.

Article  PubMed  PubMed Central  Google Scholar 

Barsanti L, Passarelli V, Evangelista V, Frassanito AM, Gualtieri P. Chemistry, physico-chemistry and applications linked to biological activities of β-glucans. Nat Prod Rep. 2011;28(3):457–66. https://doi.org/10.1039/c0np00018c.

Article  CAS  PubMed  Google Scholar 

Binmama S, Dang CP, Visitchanakun P, Hiengrach P, Somboonna N, Cheibchalard T. Beta-glucan from S. cerevisiae protected AOM-induced colon cancer in cGAS-deficient mice partly through Dectin-1-manipulated macrophage cell energy. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms231810951.

Article  PubMed  PubMed Central  Google Scholar 

Ding C, Shrestha R, Zhu X, Geller AE, Wu S, Woeste MR, et al. Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis. Nat Immunol. 2023;24(2):239–54. https://doi.org/10.1038/s41590-022-01388-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang M, Kim JA, Huang AY. Optimizing tumor microenvironment for cancer immunotherapy: β-glucan-based nanoparticles. Front Immunol. 2018;9:341. https://doi.org/10.3389/fimmu.2018.00341.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W-J, Wang J, Ouyang C, Chen C, Xu X-F, Ye X-Q. Overview of Serpin B9 and its roles in cancer. Oncol Rep. 2021;46(3):190. https://doi.org/10.3892/or.2021.8141.

Article  CAS  PubMed  Google Scholar 

Huang H, Mu Y, Li S. The biological function of Serpinb9 and Serpinb9-based therapy. Front Immunol. 2024;15:1422113. https://doi.org/10.3389/fimmu.2024.1422113.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rizzitelli A, Meuter S, Vega Ramos J, Bird CH, Mintern JD, Mangan MS, et al. Serpinb9 (Spi6)-deficient mice are impaired in dendritic cell‐mediated antigen cross‐presentation. Immunol Cell Biol. 2012;90(9):841–51. https://doi.org/10.1038/icb.2012.29.

Article  CAS  PubMed  Google Scholar 

Mohammadi A, Sharifi A, Pourpaknia R, Mohammadian S, Sahebkar A. Manipulating macrophage polarization and function using classical HDAC inhibitors: implications for autoimmunity and inflammation. Crit Rev Oncol/Hematol. 2018;128:1–18. https://doi.org/10.1016/j.critrevonc.2018.05.009.

Article  PubMed  Google Scholar 

Zhou D, Huang C, Lin Z, Zhan S, Kong L, Fang C, et al. Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal. 2014;26(2):192–7. https://doi.org/10.1016/j.cellsig.2013.11.004.

Article  CAS  PubMed  Google Scholar 

Lawrence T. Coordinated regulation of signaling pathways during macrophage activation. Myeloid Cells in Health and Disease: A Synthesis. 2017:543–52. https://doi.org/10.1128/microbiolspec.MCHD-0025-2015

Medema J, De Jong J, Peltenburg L, Verdegaal E, Gorter A, Bres S, et al. Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. Proc Natl Acad Sci U S A. 2001;98(20):11515–20. https://doi.org/10.1073/pnas.201398198.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cunningham TD, Jiang X, Shapiro DJ. Expression of high levels of human proteinase inhibitor 9 blocks both perforin/granzyme and Fas/Fas ligand-mediated cytotoxicity. Cell Immunol. 2007;245(1):32–41. https://doi.org/10.1016/j.cellimm.2007.03.004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ray M, Hostetter DR, Loeb CR, Simko J, Craik CS. Inhibition of granzyme B by PI-9 protects prostate cancer cells from apoptosis. Prostate. 2012;72(8):846–55. https://doi.org/10.1002/pros.21486.

Article  CAS  PubMed  Google Scholar 

Bladergroen BA, Strik M, Bovenschen N, van Berkum O, Scheffer GL, Meijer CJ, et al. The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. J Immunol. 2001;166(5):3218–25. https://doi.org/10.4049/jimmunol.166.5.3218.

Article  CAS  PubMed  Google Scholar 

Young JD-E, Hengartner H, Podack ER, Cohn ZA. Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity. Cell. 1986;44(6):849–59. https://doi.org/10.1016/0092-8674(86)90007-3.

Article  CAS  PubMed  Google Scholar 

Nakajima H, Park HL, Henkart PA. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J Exp Med. 1995;181(3):1037–46. https://doi.org/10.1084/jem.181.3.1037.

Article  CAS  PubMed  Google Scholar 

Lovo E, Zhang M, Wang L, Ashton-Rickardt PG. Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death. J Immunol. 2012;188(3):1057–63.

Article  CAS  PubMed  Google Scholar 

Jiang L, Wang Y-J, Zhao J, Uehara M, Hou Q, Kasinath V, et al. Direct tumor killing and immunotherapy through anti-SerpinB9 therapy. Cell. 2020;183(5):1219–33. https://doi.org/10.1016/j.cell.2020.10.045.

Article  CAS  PubMed  PubMed Central