Sleep Neurophysiology and Psychiatric Disorders: a Transdiagnostic Framework for Mechanistic and Therapeutic Insight

American Psychiatric A (2022).

Organization WH (2022) International Classification of Diseases for Mortality and Morbidity Statistics (11th Revision). (World Health Organization, Geneva).

Wulff K, Gatti S, Wettstein JG, Foster RG. Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci. 2010;11(8):589–99.

Article  PubMed  CAS  Google Scholar 

Benca RM, Obermeyer WH, Thisted RA, Gillin JC. Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry. 1992;49(8):651–68. discussion 669–670.

Article  PubMed  CAS  Google Scholar 

Benca RM. Rem sleep and mental disorders on the 70th anniversary of the discovery of REM sleep. J Sleep Res. 2025;34(2): e14364.

Article  PubMed  Google Scholar 

Baglioni C, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135(1–3):10–9.

Article  PubMed  Google Scholar 

Meyer N, et al. The sleep-circadian interface: a window into mental disorders. Proc Natl Acad Sci U S A. 2024;121(9): e2214756121.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lüthi A, Nedergaard M. Anything but small: microarousals stand at the crossroad between noradrenaline signaling and key sleep functions. Neuron. 2025;113(4):509–23.

Article  PubMed  Google Scholar 

Doucet GE, et al. Transdiagnostic and disease-specific abnormalities in the default-mode network hubs in psychiatric disorders: a meta-analysis of resting-state functional imaging studies. Eur Psychiatry. 2020;63(1): e57.

Article  PubMed  PubMed Central  Google Scholar 

Harvey AG, Murray G, Chandler RA, Soehner A. Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms. Clin Psychol Rev. 2011;31(2):225–35.

Article  PubMed  Google Scholar 

Krystal AD. Psychiatric disorders and sleep. Neurol Clin. 2012;30(4):1389–413.

Article  PubMed  PubMed Central  Google Scholar 

Riemann D, Krone LB, Wulff K, Nissen C. Sleep, insomnia, and depression. Neuropsychopharmacology. 2020;45(1):74–89.

Article  PubMed  Google Scholar 

Kaplan KA, Harvey AG. Hypersomnia across mood disorders: a review and synthesis. Sleep Med Rev. 2009;13(4):275–85.

Article  PubMed  Google Scholar 

Högl B, Stefani A, Videnovic A. Idiopathic REM sleep behaviour disorder and neurodegeneration — an update. Nat Rev Neurol. 2018;14(1):40–55.

Article  PubMed  Google Scholar 

Germain A. Sleep disturbances as the hallmark of PTSD: where are we now?? Am J Psychiatry. 2013;170(4):372–82.

Article  PubMed  PubMed Central  Google Scholar 

Barone DA. Dream enactment behavior-a real nightmare: a review of post-traumatic stress disorder, REM sleep behavior disorder, and trauma-associated sleep disorder. J Clin Sleep Med. 2020;16(11):1943–8.

Article  PubMed  PubMed Central  Google Scholar 

Xie C, Makwana A, Driver H, Shukla G. Association of early-onset psychiatric disorders with REM sleep behavior disorder – A retrospective study. Sleep Med. 2025;127:127–32.

Article  PubMed  Google Scholar 

Rosenzweig I, Osorio RS. Sleep and psychiatric disorders. Oxford Handbook of Sleep Medicine, ed Leschziner G (Oxford University Press). 2022;p 0.

Khazaie H, et al. Functional reorganization in obstructive sleep apnoea and insomnia: a systematic review of the resting-state fMRI. Neurosci Biobehav Rev. 2017;77:219–31.

Article  PubMed  PubMed Central  Google Scholar 

Rosenzweig I, Gosselin N, Bucks RS. Cognitive and Neurologic Aspects of Obstructive Sleep Apnea. Encyclopedia of Respiratory Medicine (Second Edition), ed Janes SM (Academic Press, Oxford). 2022;60–74.

Drakatos P, et al. Periodic limb movements during sleep: a narrative review. J Thorac Dis. 2021;13(11):6476–94.

Article  PubMed  PubMed Central  Google Scholar 

Gnoni V, et al. Distinct cognitive changes in male patients with obstructive sleep apnoea without co-morbidities. Front Sleep. 2023;2:1097946.

Article  PubMed  PubMed Central  Google Scholar 

Grandner MA, Fernandez FX. The translational neuroscience of sleep: a contextual framework. Science. 2021;374(6567):568–73.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Freeman D, Sheaves B, Waite F, Harvey AG, Harrison PJ. Sleep disturbance and psychiatric disorders. Lancet Psychiatry. 2020;7(7):628–37.

Article  PubMed  Google Scholar 

Picard-Deland C, Carr M, Paquette T, Saint-Onge K, Nielsen T. Sleep spindle and psychopathology characteristics of frequent nightmare recallers. Sleep Med. 2018;50:113–31.

Article  PubMed  Google Scholar 

Huidobro N, et al. Electroencephalographic biomarkers for neuropsychiatric diseases: the state of the art. Bioengineering. 2025. https://doi.org/10.3390/bioengineering12030295.

Article  PubMed  PubMed Central  Google Scholar 

McLoughlin G, Makeig S, Tsuang MT. In search of biomarkers in psychiatry: EEG-based measures of brain function. Am J Med Genet B Neuropsychiatr Genet. 2014;165B(2):111–21.

Article  PubMed  Google Scholar 

Petit JM, et al. Sleep spindles in people with schizophrenia, schizoaffective disorders or bipolar disorders: a pilot study in a general population-based cohort. BMC Psychiatry. 2022;22(1):758.

Article  PubMed  PubMed Central  Google Scholar 

Ferrarelli F, Tononi G. Reduced sleep spindle activity point to a TRN-MD thalamus-PFC circuit dysfunction in schizophrenia. Schizophr Res. 2017;180:36–43.

Article  PubMed  Google Scholar 

Vukadinovic Z, Rosenzweig I. Abnormalities in thalamic neurophysiology in schizophrenia: could psychosis be a result of potassium channel dysfunction? Neurosci Biobehav Rev. 2012;36(2):960–8.

Article  PubMed  CAS  Google Scholar 

Vukadinovic Z, Herman MS, Rosenzweig I. Cannabis, psychosis and the thalamus: a theoretical review. Neurosci Biobehav Rev. 2013;37(4):658–67.

Article  PubMed  Google Scholar 

Manoach DS, Pan JQ, Purcell SM, Stickgold R. Reduced sleep spindles in schizophrenia: a treatable endophenotype that links risk genes to impaired cognition?? Biol Psychiatry. 2016;80(8):599–608.

Article  PubMed  Google Scholar 

Zhang Y, Quinones GM, Ferrarelli F. Sleep spindle and slow wave abnormalities in schizophrenia and other psychotic disorders: recent findings and future directions. Schizophr Res. 2020;221:29–36.

Article  PubMed  Google Scholar 

Ritter PS, et al. Sleep spindles in bipolar disorder - a comparison to healthy control subjects. Acta Psychiatr Scand. 2018;138(2):163–72.

Article  PubMed  CAS  Google Scholar 

Plante DT, et al. Topographic and sex-related differences in sleep spindles in major depressive disorder: a high-density EEG investigation. J Affect Disord. 2013;146(1):120–5.

Article  PubMed  CAS  Google Scholar 

Parrino L, Vaudano AE. The resilient brain and the guardians of sleep: new perspectives on old assumptions. Sleep Med Rev. 2018;39:98–107.

Article  PubMed  Google Scholar 

Farina B. Microstructure of sleep in depressed patients according to the cyclic alternating pattern. J Affect Disord. 2003;77(3):227–35.

Article  PubMed  Google Scholar 

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