The Role of the human microbiome in neurodegenerative diseases: A Perspective

Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji OR, Salami M (2016) Effect of probiotic supplementation on cognitive function and metabolic status in alzheimer’s disease: a randomized, double-blind and controlled trial. Front Aging Neurosci 8:229544

Article  Google Scholar 

Almeida A, Mitchell AL, Boland M, Forster SC, Gloor GB, Tarkowska A, Finn RD (2019) A new genomic blueprint of the human gut microbiota. Nature 568(7753):499–504

Article  CAS  PubMed  PubMed Central  Google Scholar 

Askarova S, Umbayev B, Masoud AR, Kaiyrlykyzy A, Safarova Y, Tsoy A, Kushugulova A (2020) The links between the gut microbiome, aging, modern lifestyle and alzheimer’s disease. Front Cell Infect Microbiol 10:104

Article  CAS  PubMed  PubMed Central  Google Scholar 

An K, Kim MJ, Teplansky K, Green JR, Campbell TF, Yunusova Y, Wang J (2018) Automatic early detection of amyotrophic lateral sclerosis from intelligible speech using convolutional neural networks. In: Interspeech. pp. 1913–1917

Barichella M, Pacchetti C, Bolliri C, Cassani E, Iorio L, Pusani C, Cereda E (2016) Probiotics and prebiotic fiber for constipation associated with Parkinson disease: an RCT. Neurology 87(12):1274–1280

Article  CAS  PubMed  Google Scholar 

Barnhart MM, Chapman MR (2006) Curli biogenesis and function. Annu Rev Microbiol 60(1):131–147

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bedarf JR, Hildebrand F, Coelho LP, Sunagawa S, Bahram M, Goeser F, Wüllner U (2017) Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve parkinson’s disease patients. Genome Med 9:1–13

Google Scholar 

Bhattacharjee S, Lukiw WJ (2013) Alzheimer’s disease and the Microbiome. Front Cell Neurosci 7:153

Article  PubMed  PubMed Central  Google Scholar 

Blacher E, Bashiardes S, Shapiro H, Rothschild D, Mor U, Dori-Bachash M, Elinav E (2019) Potential roles of gut Microbiome and metabolites in modulating ALS in mice. Nature 572(7770):474–480

Article  CAS  PubMed  Google Scholar 

Blazkova B, Pastorkova A, Solansky I, Veleminsky Jr M, Veleminsky M, Rossnerova A, Sram RJ (2020) The impact of Cesarean and vaginal delivery on results of psychological cognitive test in 5 year old children. Medicina 56(10):554

Article  PubMed  PubMed Central  Google Scholar 

Boertien JM, Pereira PA, Aho VT, Scheperjans F (2019) Increasing comparability and utility of gut Microbiome studies in parkinson’s disease: a systematic review. J Parkinson’s Disease 9(s2):S297–S312

Article  Google Scholar 

Bonfili L, Cecarini V, Cuccioloni M, Angeletti M, Berardi S, Scarpona S, Eleuteri AM (2018) SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model. Mol Neurobiol 55:7987–8000

Article  CAS  PubMed  PubMed Central  Google Scholar 

Braak H, Rüb U, Gai WP, Tredici D, K (2003) Idiopathic parkinson’s disease: possible routes by which vulnerable neuronal types May be subject to neuroinvasion by an unknown pathogen. J Neural Transm 110:517–536

Article  CAS  PubMed  Google Scholar 

Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, Pettersson S (2014) The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med 6(263):263ra158–263ra158

Article  PubMed  PubMed Central  Google Scholar 

Çamcı G, Oğuz S (2016) Association between parkinson’s disease and Helicobacter pylori. J Clin Neurol (Seoul Korea) 12(2):147

Article  Google Scholar 

Caputi V, Giron MC (2018) Microbiome-gut-brain axis and toll-like receptors in parkinson’s disease. Int J Mol Sci 19(6):1689

Article  PubMed  PubMed Central  Google Scholar 

Carabotti M, Scirocco A, Maselli MA, Severi C (2015) The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals Gastroenterology: Q Publication Hellenic Soc Gastroenterol 28(2):203

Google Scholar 

Casani-Cubel J, Benlloch M, Sanchis-Sanchis CE, Marin R, Lajara-Romance JM, de la Orti R, J. E (2021) The impact of microbiota on the pathogenesis of amyotrophic lateral sclerosis and the possible benefits of polyphenols. An overview. Metabolites 11(2):120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cattaneo A, Cattane N, Galluzzi S, Provasi S, Lopizzo N, Festari C, Group IF (2017) Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol Aging 49:60–68

Article  CAS  PubMed  Google Scholar 

Chiang HL, Lin CH (2019) Altered gut Microbiome and intestinal pathology in parkinson’s disease. J Mov Disorders 12(2):67

Article  Google Scholar 

Cirstea MS, Yu AC, Golz E, Sundvick K, Kliger D, Radisavljevic N, Appel-Cresswell S (2020) Microbiota composition and metabolism are associated with gut function in parkinson’s disease. Mov Disord 35(7):1208–1217

Article  CAS  PubMed  Google Scholar 

Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, Cryan J (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18(6):666–673

Article  CAS  PubMed  Google Scholar 

Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13(10):701–712

Article  CAS  PubMed  Google Scholar 

Cryan JF, Dinan TG (2015) Microbiota and neuroimmune signalling—Metchnikoff to microglia. Nat Reviews Gastroenterol Hepatol 12(9):494–496

Article  Google Scholar 

Cuffaro F, Lamminpää I, Niccolai E, Amedei A (2024) Nutritional and Microbiota-Based approaches in amyotrophic lateral sclerosis: from prevention to treatment. Nutrients 17(1):102

Article  PubMed  PubMed Central  Google Scholar 

Dauer W, Przedborski S (2003) Parkinson’s disease: mechanisms and models. Neuron 39(6):889–909

Article  CAS  PubMed  Google Scholar 

Dodiya HB, Forsyth CB, Voigt RM, Engen PA, Patel J, Shaikh M, Keshavarzian A (2020) Chronic stress-induced gut dysfunction exacerbates parkinson’s disease phenotype and pathology in a rotenone-induced mouse model of parkinson’s disease. Neurobiol Dis 135:104352

Article  CAS  PubMed  Google Scholar 

Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R (2010) Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci 107(26):11971–11975

Douglas AE (2018) Which experimental systems should we use for human Microbiome science? PLoS Biol 16(3):e2005245

Article  PubMed  PubMed Central  Google Scholar 

Dueholm MS, Sondergaard MT, Nilsson M, Christiansen G, Stensballe A, Overgaard MT (2013) Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation. Microbiologyopen 2: 365–382

Duvallet C, Gibbons SM, Gurry T, Irizarry RA, Alm EJ (2017) Meta-analysis of gut Microbiome studies identifies disease-specific and shared responses. Nat Commun 8(1):1784

Article  PubMed  PubMed Central  Google Scholar 

Erny D, Hrabě de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Prinz M (2015) Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci 18(7):965–977

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang X, Wang X, Yang S, Meng F, Wang X, Wei H, Chen T (2016) Evaluation of the microbial diversity in amyotrophic lateral sclerosis using high-throughput sequencing. Front Microbiol 7:1479

Article  PubMed  PubMed Central  Google Scholar 

Fasano A, Aquino CC, Krauss JK, Honey CR, Bloem BR (2015a) Axial disability and deep brain stimulation in patients with Parkinson disease. Nat Reviews Neurol 11(2):98–110

Article  Google Scholar 

Fasano A, Visanji NP, Liu LW, Lang AE, Pfeiffer RF (2015b) Gastrointestinal dysfunction in parkinson’s disease. Lancet Neurol 14(6):625–639

Article  CAS  PubMed 

Comments (0)

No login
gif