Reviews:

Microbial Cell, Vol. 12, No. 1, pp. 242 - 254; doi: 10.15698/mic2025.08.859

Chang-Lin Chen1,a, Wei-Ling Huang1, Alexander Rapoport2, Rimantas Daugelavičius3 and Chuang-Rung Chang1

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Mitochondria are essential organelles that form a dynamic network within cells. The fusion, fission, and transport processes among mitochondria must reach a balance, which is achieved through complex regulatory mechanisms. These dynamic processes and regulatory pathways are highly conserved across species and are coordinated to help cells respond to environmental stress. The budding yeast Saccharomyces cerevisiae has become an important model organism for studying mitochondria dynamics due to its genetic tractability and the conservation of key mitochondrial regulators. Previous research on mitochondria dynamics in yeast has provided valuable insights into the regulatory pathways in eukaryotic cells. It has helped to elucidate the mechanisms related to diseases associated with disrupted mitochondria dynamics. This review explores the molecular mechanisms underlying mitochondria dynamics and their physiological roles in Saccharomyces cerevisiae. The knowledge we learned from the primary eukaryotic yeast cell will aid us in advancing future research on the regulatory mechanisms of mitochondria in both health and disease.

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ACKNOWLEDGMENTS

This research was funded by the Latvian Council of Science Nr. (LV-LT-TW/2025/1 for Rapoport, A), Research Council of Lithuania and the Taiwanese Representative Office in Lithuania (S-LLT-25-3 for Daugelavičius, R), as well as the National Science and Technol-ogy Council (113-2320-B-007-003 and 114-2923-B-007 -001 -MY3 for Chang, C. R.). This review is intended to be used as a reference for those not experts in the field; we apologize to the respected scientists who have contributed to yeast mitochondria dynamics but are not indicated herein due to our limited capacity. We thank the staff of the Taiwan Yeast Bioresource Center at the First Core Labs Na-tional Taiwan University College of Medicine for sharing biore-sources. We would also like to thank Professor Tzu-Hao Cheng (National Yang Ming Chiao Tung University), Professor Horng-Dar Wang (National Tsing Hua University) and Professor Ruth Hua-Wen Fu (National Tsing Hua University) for their support during the preparation of this manuscript.

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© 2025

The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae by Chen et al. is licensed under a Creative Commons Attribution 4.0 International License.