Ali MJ, Honavar SG, Reddy VA (2013) Distant metastatic retinoblastoma without central nervous system involvement. Indian J Ophthalmol 61:357–359. https://doi.org/10.4103/0301-4738.97077

Article  PubMed  PubMed Central  Google Scholar 

Babu VS, Mallipatna A, Dudeja G, Shetty R, Nair AP, Tun SBB, Ho CEH, Chaurasia SS, Bhattacharya SS, Verma NK, Lakshminarayanan R, Guha N, Heymans S, Barathi VA, Ghosh A (2023) Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors. Transl Res 261:41–56. https://doi.org/10.1016/j.trsl.2023.07.001

Article  PubMed  CAS  Google Scholar 

Blanco S, Frye M (2014) Role of RNA methyltransferases in tissue renewal and pathology. Curr Opin Cell Biol 31:1–7. https://doi.org/10.1016/j.ceb.2014.06.006

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen X, Li A, Sun BF, Yang Y, Han YN, Yuan X, Chen RX, Wei WS, Liu Y, Gao CC, Chen YS, Zhang M, Ma XD, Liu ZW, Luo JH, Lyu C, Wang HL, Ma J, Zhao YL, Zhou FJ, Huang Y, Xie D, Yang YG (2019) 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nat Cell Biol 21:978–990. https://doi.org/10.1038/s41556-019-0361-y

Article  PubMed  CAS  Google Scholar 

Chen YS, Yang WL, Zhao YL, Yang YG (2021) Dynamic transcriptomic m(5) C and its regulatory role in RNA processing. Wiley Interdiscip Rev RNA 12:e1639. https://doi.org/10.1002/wrna.1639

Article  PubMed  CAS  Google Scholar 

Chen B, Deng Y, Hong Y, Fan L, Zhai X, Hu H, Yin S, Chen Q, Xie X, Ren X, Zhao J, Jiang C (2024) Metabolic recoding of NSUN2-Mediated m(5)C modification promotes the progression of colorectal Cancer via the NSUN2/YBX1/m(5)C-ENO1 positive feedback loop. Adv Sci (Weinh) 11:e2309840. https://doi.org/10.1002/advs.202309840

Article  PubMed  CAS  Google Scholar 

Cozza R, De Ioris MA, Ilari I, Devito R, Fidani P, De Sio L, Demelas F, Romanzo A, Donfrancesco A (2009) Metastatic retinoblastoma: single institution experience over two decades. Br J Ophthalmol 93:1163–1166. https://doi.org/10.1136/bjo.2008.148932

Article  PubMed  CAS  Google Scholar 

Du X, Cheng C, Yang Y, Fan B, Wang P, Xia H, Ni X, Liu Q, Lu L, Wei L (2024) NSUN2 promotes lung adenocarcinoma progression through stabilizing PIK3R2 mRNA in an m(5)C-dependent manner. Mol Carcinog 63:962–976. https://doi.org/10.1002/mc.23701

Article  PubMed  CAS  Google Scholar 

Dubin DT, Taylor RH (1975) The methylation state of Poly A-containing messenger RNA from cultured hamster cells. Nucleic Acids Res 2:1653–1668. https://doi.org/10.1093/nar/2.10.1653

Article  PubMed  PubMed Central  CAS  Google Scholar 

Flores JV, Cordero-Espinoza L, Oeztuerk-Winder F, Andersson-Rolf A, Selmi T, Blanco S, Tailor J, Dietmann S, Frye M (2017) Cytosine-5 RNA methylation regulates neural stem cell differentiation and motility. Stem Cell Rep 8:112–124. https://doi.org/10.1016/j.stemcr.2016.11.014

Article  CAS  Google Scholar 

Frye M, Watt FM (2006) The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Curr Biol 16:971–981. https://doi.org/10.1016/j.cub.2006.04.027

Article  PubMed  CAS  Google Scholar 

Huang S, Cao C, Tang D, Liu Y, Zhou W, Liu L, Zheng X, He Q, Wang A (2024) NSUN2 promotes head and neck squamous cell carcinoma progression by targeting EMT-Related gene LAMC2 in an m(5)C-YBX1-Dependent manner. Biomedicines 12. https://doi.org/10.3390/biomedicines12112533

Ishaq H, Patel BC (2024) Retinoblastoma. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Bhupendra patel declares no relevant financial relationships with ineligible companies. StatPearls Publishing. Copyright (2024) © StatPearls Publishing LLC

Li R, Li S, Shen L, Li J, Zhang D, Yu J, Huang L, Liu N, Lu H, Xu M (2024a) LINC00618 facilitates growth and metastasis of hepatocellular carcinoma via elevating cholesterol synthesis by promoting NSUN2-mediated SREBP2 m5C modification. Ecotoxicol Environ Saf 285:117064. https://doi.org/10.1016/j.ecoenv.2024.117064

Article  PubMed  CAS  Google Scholar 

Li YJ, Guo Q, Ye MS, Cai G, Xiao WF, Deng S, Xiao Y (2024b) YBX1 promotes type H vessel-dependent bone formation in an m5C-dependent manner. JCI Insight 9. https://doi.org/10.1172/jci.insight.172345

Liu L, Chen Y, Zhang T, Cui G, Wang W, Zhang G, Li J, Zhang Y, Wang Y, Zou Y, Ren Z, Xue W, Sun R (2024a) [Not available]. Adv Sci (Weinh) 11:e2302379. https://doi.org/10.1002/advs.202302379

Article  PubMed  CAS  Google Scholar 

Liu L, Yu L, Wang Y, Zhou L, Liu Y, Pan X, Huang J (2024b) Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy. Pharmacol Res 207:107305. https://doi.org/10.1016/j.phrs.2024.107305

Article  PubMed  CAS  Google Scholar 

Liu X, Wei Q, Yang C, Zhao H, Xu J, Mobet Y, Luo Q, Yang D, Zuo X, Chen N, Yang Y, Li L, Wang W, Yu J, Xu J, Liu T, Yi P (2024c) RNA m(5)C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer. Exp Mol Med 56:600–615. https://doi.org/10.1038/s12276-024-01184-4

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lu Y, Yang L, Feng Q, Liu Y, Sun X, Liu D, Qiao L, Liu Z (2024) RNA 5-Methylcytosine modification: regulatory molecules, biological functions, and human diseases. Genomics Proteom Bioinf. https://doi.org/10.1093/gpbjnl/qzae063

Article  Google Scholar 

Okamoto M, Hirata S, Sato S, Koga S, Fujii M, Qi G, Ogawa I, Takata T, Shimamoto F, Tatsuka M (2012) Frequent increased gene copy number and high protein expression of tRNA (cytosine-5-)-methyltransferase (NSUN2) in human cancers. DNA Cell Biol 31:660–671. https://doi.org/10.1089/dna.2011.1446

Article  PubMed  CAS  Google Scholar 

Pang Q, Huang S, Cao J (2024) HKDC1 enhances the proliferation, migration and Glycolysis of pancreatic adenocarcinoma and is linked to immune infiltration. J Cancer 15:1983–1993. https://doi.org/10.7150/jca.92823

Article  PubMed  PubMed Central  CAS  Google Scholar 

Raval V, Singh A (2024) Management of retinoblastoma: are we there yet? Can J Ophthalmol 59:376–379. https://doi.org/10.1016/j.jcjo.2024.01.013

Article  PubMed  Google Scholar 

Reid R, Greene PJ, Santi DV (1999) Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences. Nucleic Acids Res 27:3138–3145. https://doi.org/10.1093/nar/27.15.3138

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schumann U, Zhang HN, Sibbritt T, Pan A, Horvath A, Gross S, Clark SJ, Yang L, Preiss T (2020) Multiple links between 5-methylcytosine content of mRNA and translation. BMC Biol 18:40. https://doi.org/10.1186/s12915-020-00769-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shen X, Sun H, Shu S, Tang W, Yuan Y, Su H, Li Y, Fan H (2024) Suppression of NSUN2 enhances the sensitivity to chemosensitivity and inhibits proliferation by mediating cell apoptosis in gastric cancer. Pathol Res Pract 253:154986. https://doi.org/10.1016/j.prp.2023.154986

Article  PubMed  CAS  Google Scholar 

Song K, Li B, Chen YY, Wang H, Liu KC, Tan W, Zou J (2021) LRPPRC regulates metastasis and Glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma. Mol Ther Oncolytics 22:582–591. https://doi.org/10.1016/j.omto.2021.06.009

Article  PubMed  PubMed Central  CAS  Google Scholar 

Suresh Babu V, Dudeja G, Sa D, Bisht A, Shetty R, Heymans S, Guha N, Ghosh A (2022) Lack of retinoblastoma protein shifts tumor metabolism from Glycolysis to OXPHOS and allows the use of alternate fuels. Cells 11. https://doi.org/10.3390/cells11203182

Tang Q, Li L, Wang Y, Wu P, Hou X, Ouyang J, Fan C, Li Z, Wang F, Guo C, Zhou M, Liao Q, Wang H, Xiang B, Jiang W, Li G, Zeng Z, Xiong W (2023) RNA modifications in cancer. Br J Cancer 129:204–221. https://doi.org/10.1038/s41416-023-02275-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tian J, Gao J, Cheng C, Xu Z, Chen X, Wu Y, Fu G, Jin B (2024) NOP2-mediated 5-methylcytosine modification of APOL1 messenger RNA activates PI3K-Akt and facilitates clear cell renal cell carcinoma progression. Int J Biol Sci 20:4853–4871. https://doi.org/10.7150/ijbs.97503

Article  PubMed  PubMed Central  Google Scholar 

Wang X, Shi B, Zhao Y, Lu Q, Fei X, Lu C, Li C, Chen H (2020) HKDC1 promotes the tumorigenesis and Glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway. Cancer Cell Int 20:450. https://doi.org/10.1186/s12935-020-01539-7