Alireza M, Mohsen A, Rozita K, Mahmoud T, Gordon AF, Hoda R et al (2024) The angiotensin type 1 receptor: A drug target to reduce the risk of organ transplant rejection. Lett Drug Des Discov 21(13):2537–2544
An Y, Duan H (2022) The role of m6A RNA methylation in cancer metabolism. Mol Cancer 21(1):14
CAS PubMed PubMed Central Google Scholar
Dixon DL, Trankle C, Buckley L, Parod E, Carbone S, Van Tassell BW et al (2016) A review of PCSK9 Inhibition and its effects beyond LDL receptors. J Clin Lipidol 10(5):1073–1080
Fu C, Feng L, Zhang J, Sun D (2022) Bioinformatic analyses of the role of m6A RNA methylation regulators in abdominal aortic aneurysm. Ann Transl Med 10(10):547
CAS PubMed PubMed Central Google Scholar
Golledge J, Lu HS, Shah S (2024) Proprotein convertase subtilisin/kexin type 9 as a drug target for abdominal aortic aneurysm. Curr Opin Lipidol 35(5):241–247
Grześk G, Dorota B, Wołowiec Ł, Wołowiec A, Osiak J, Kozakiewicz M et al (2022) Safety of PCSK9 inhibitors. Biomed Pharmacother 156:113957
Guo Y, Tang Z, Yan B, Yin H, Tai S, Peng J et al (2022) PCSK9 (Proprotein convertase subtilisin/kexin type 9) triggers vascular smooth muscle cell senescence and apoptosis: implication of its direct role in degenerative vascular disease. Arterioscler Thromb Vasc Biol 42(1):67–86
Haque K, Bhargava P (2022) Abdominal aortic aneurysm. Am Fam Physician 106(2):165–172
He PC, He C (2021) m(6) A RNA methylation: from mechanisms to therapeutic potential. EMBO J 40(3):e105977
CAS PubMed PubMed Central Google Scholar
Huang Q, Mo J, Liao Z, Chen X, Zhang B (2022) The RNA m(6)A writer WTAP in diseases: structure, roles, and mechanisms. Cell Death Dis 13(10):852
CAS PubMed PubMed Central Google Scholar
Huang MX, Piao HL, Wang Y, Zhu ZC, Xu RH, Wang TC et al (2023) Circ_0022920 maintains the contractile phenotype of human aortic vascular smooth muscle cells via sponging microRNA-650 and promoting transforming growth factor Beta receptor 1 expression in angiotensin II-Induced models for aortic dissection. J Am Heart Assoc 12(7):e027425
PubMed PubMed Central Google Scholar
Hummelgaard S, Vilstrup JP, Gustafsen C, Glerup S, Weyer K (2023) Targeting PCSK9 to tackle cardiovascular disease. Pharmacol Ther 249:108480
Jiang H, Sasaki T, Jin E, Kuzuya M, Cheng XW (2018) Inflammatory cells and proteases in abdominal aortic aneurysm and its complications. Curr Drug Targets 19(11):1289–1296
Li J, Zhang Z, Hu J, Wan X, Huang W, Zhang H (2022) MiR-1246 regulates the PI3K/AKT signaling pathway by targeting PIK3AP1 and inhibits thyroid cancer cell proliferation and tumor growth. Mol Cell Biochem 477(3):649–661
Mei Z, Mou Y, Zhang N, Liu X, He Z, Gu S (2023) Emerging mutual regulatory roles between m(6)A modification and MicroRNAs. Int J Mol Sci 24(1):773
CAS PubMed PubMed Central Google Scholar
O’Donnell TFX, Landon BE, Schermerhorn ML (2019) AAA screening should be expanded. Circulation 140(11):889–890
Peng Z, Lv SJ, Chen H, Rao H, Guo Z, Wan Q et al (2025) Disruption of PCSK9 suppresses inflammation and attenuates abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol 45(1):e1–e14
Pi S, Xiong S, Yuan Y, Deng H (2024) The role of inflammasome in abdominal aortic aneurysm and its potential drugs. Int J Mol Sci 25(9):5001
CAS PubMed PubMed Central Google Scholar
Qin Y, Li L, Luo E, Hou J, Yan G, Wang D et al (2020) Role of m6A RNA methylation in cardiovascular disease (Review). Int J Mol Med 46(6):1958–1972
CAS PubMed PubMed Central Google Scholar
Schanzer A, Oderich GS (2021) Management of abdominal aortic aneurysms. N Engl J Med 385(18):1690–1698
Seidah NG, Awan Z, Chrétien M, Mbikay M (2014) PCSK9: a key modulator of cardiovascular health. Circ Res 114(6):1022–1036
Shi H, Wei J, He C (2019) Where, when, and how: Context-Dependent functions of RNA methylation writers, readers, and erasers. Mol Cell 74(4):640–650
CAS PubMed PubMed Central Google Scholar
Small TW, Penalva LO, Pickering JG (2007) Vascular biology and the sex of flies: regulation of vascular smooth muscle cell proliferation by wilms’ tumor 1-associating protein. Trends Cardiovasc Med 17(7):230–234
Tian Z, Li W, Wang J, Li S (2025) WTAP-mediated m6A modification on BASP1 mRNA contributes to ferroptosis in AAA. Gen Thorac Cardiovasc Surg
Vandestienne M, Zhang Y, Santos-Zas I, Al-Rifai R, Joffre J, Giraud A et al (2021) TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm. J Clin Invest 131(2):e142468
CAS PubMed PubMed Central Google Scholar
Wang LJ, Xue Y, Li H, Huo R, Yan Z, Wang J et al (2020) Wilms’ tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic Silencing of Desmoplakin in brain arteriovenous malformation. J Cell Mol Med 24(9):4981–4991
CAS PubMed PubMed Central Google Scholar
Wang J, Zhang J, Ma Y, Zeng Y, Lu C, Yang F et al (2021) WTAP promotes myocardial ischemia/reperfusion injury by increasing Endoplasmic reticulum stress via regulating m(6)A modification of ATF4 mRNA. Aging 13(8):11135–11149
CAS PubMed PubMed Central Google Scholar
Wang K, Kan Q, Ye Y, Qiu J, Huang L, Wu R et al (2022) Novel insight of N(6)-methyladenosine modified subtypes in abdominal aortic aneurysm. Front Genet 13:1055396
CAS PubMed PubMed Central Google Scholar
Zhu TY, Hong LL, Ling ZQ (2023) Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential. Biomark Res 11(1):62
PubMed PubMed Central Google Scholar
Zhuang J, Zhu H, Cheng Z, Hu X, Yu X, Li J et al (2023) PCSK9, a novel immune and ferroptosis related gene in abdominal aortic aneurysm neck. Sci Rep 13(1):6054
Comments (0)