Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng C-Y, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2:e106–16.
Chaudhary V, Mar F, Amador MJ, Chang A, Gibson K, Joussen AM, et al. Emerging clinical evidence of a dual role for Ang-2 and VEGF-A blockade with faricimab in retinal diseases. Graefes Arch Clin Exp Ophthalmol. 2025;263:1239–47.
Maguire MG, Martin DF, Ying G, Jaffe GJ, Daniel E, Grunwald JE, et al. Five-year outcomes with anti–vascular endothelial growth factor treatment of neovascular age-related macular degeneration. Ophthalmology. 2016;123:1751–61.
Joussen AM, Ricci F, Paris LP, Korn C, Quezada-Ruiz C, Zarbin M. Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data. Eye. 2021;35:1305–16.
PubMed PubMed Central Google Scholar
Berkowitz ST, Sternberg P, Feng X, Chen Q, Patel S. Analysis of anti–vascular endothelial growth factor injection claims data in US medicare part B beneficiaries from 2012 to 2015. JAMA Ophthalmol. 2019;137:921.
PubMed PubMed Central Google Scholar
Wolf A, Kampik A. Efficacy of treatment with ranibizumab in patients with wet age-related macular degeneration in routine clinical care: data from the COMPASS health services research. Graefes Arch Clin Exp Ophthalmol. 2014;252:647–55.
CAS PubMed PubMed Central Google Scholar
Boulanger-Scemama E, Querques G, About F, Puche N, Srour M, Mane V, et al. Ranibizumab for exudative age-related macular degeneration: A five year study of adherence to follow-up in a real-life setting. J Fr Ophtalmol. 2015;38:620–7.
Mehta H, Tufail A, Daien V, Lee AY, Nguyen V, Ozturk M, et al. Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors. Prog Retin Eye Res. 2018;65:127–46.
Hara C, Wakabayashi T, Fukushima Y, Sayanagi K, Kawasaki R, Sato S, et al. Tachyphylaxis during treatment of exudative age-related macular degeneration with aflibercept. Graefes Arch Clin Exp Ophthalmol. 2019;257:2559–69.
Heier JS, Singh RP, Wykoff CC, Csaky KG, Lai TYY, Loewenstein A, et al. THE angiopoietin/tie pathway in retinal vascular diseases: a review. Retina. 2021;41:1–19.
Chaudhary V, Guymer R, Artignan A, Downey A, Singh RP. Real-world evidence for faricimab in neovascular age-related macular degeneration and diabetic macular edema: a scoping review. Ophthalmol Sci. 2025;5:100744.
PubMed PubMed Central Google Scholar
Samacá-Samacá D, Hernández-Castillo C, Prieto-Pinto L, Rodríguez F, Sardi C, Ocampo H, et al. Efficacy and safety of faricimab for neovascular age-related macular degeneration: a systematic review and network meta-analysis. BMJ Open Ophthalmol. 2024;9:e001702.
PubMed PubMed Central Google Scholar
Eckardt F, Lorger A, Hafner M, Klaas JE, Schworm B, Kreutzer TC, et al. Retinal and choroidal efficacy of switching treatment to faricimab in recalcitrant neovascular age related macular degeneration. Sci Rep. 2024;14:9600.
CAS PubMed PubMed Central Google Scholar
Rush RB. One-year outcomes of faricimab treatment for aflibercept-resistant neovascular age-related macular degeneration. Clin Ophthalmol. 2023;ume 17:2201–8.
Rush RB, Rush SW. Intravitreal faricimab for aflibercept-resistant neovascular age-related macular degeneration. Clin Ophthalmol. 2022;ume 16:4041–6.
Grimaldi G, Cancian G, Rizzato A, Casanova A, Perruchoud-Ader K, Clerici M, et al. Intravitreal faricimab for neovascular age-related macular degeneration previously treated with traditional anti-VEGF compounds: a real-world prospective study. Graefes Arch Clin Exp Ophthalmol. 2024;262:1151–9.
Aljundi W, Daas L, Suffo S, Seitz B, Abdin AD. First-year real-life experience with intravitreal faricimab for refractory neovascular age-related macular degeneration. Pharmaceutics. 2024;16:470.
CAS PubMed PubMed Central Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, et al. Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Database System Rev Implement Rep. 2019;18:2127–33.
Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. [Internet]. Ottawa: Ottawa Hospital Research Institute; [cited 2025 April 29]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
Reep NC, Leverett SN, Heywood RM, Baker RT, Barnes DL, Cheatham SW. The efficacy of the Mulligan concept to treat meniscal pathology: a systematic review. Int J Sports Phys Ther. 2022;17:1219–35.
Li Y, Shi Z, Zhao Y, Tan Z, Guo H, Lu Z. Comparative effectiveness and safety among different tip-design hemodialysis long-term catheters: A meta-analysis. J Vasc Access. 2024;25:448–60.
Stewart WC, Stewart JA, Demos CM, Turner M. Serious adverse event reporting. Ophthalmology. 2009;116:2485.e1.
Beck RW, Moke PS, Turpin AH, Ferris FL, SanGiovanni JP, Johnson CA, et al. A computerized method of visual acuity testing. Am J Ophthalmol. 2003;135:194–205.
Lavia C, Dallorto L, Maule M, Ceccarelli M, Fea AM. Minimally-invasive glaucoma surgeries (MIGS) for open angle glaucoma: A systematic review and meta-analysis Virgili G (ed). PLOS ONE. 2017;12:e0183142.
PubMed PubMed Central Google Scholar
Higgins JPT. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.
PubMed PubMed Central Google Scholar
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1:97–111.
Aldhanhani AA, Azzam OA, AlAli SH, Almasri KG, Aljneibi SH, Pichi F. Switch to faricimab after initial treatment with aflibercept in eyes with neovascular age-related macular degeneration. Int Ophthalmol. 2024;44:369.
PubMed PubMed Central Google Scholar
Quah N, Javed KMAA, Arbi L, Hanumunthadu D. Real-world outcomes of faricimab treatment for neovascular age-related macular degeneration and diabetic macular edema. Clin Ophthalmol. 2024;ume 18:1479–90.
Muth DR, Fasler KF, Kvanta A, Rejdak M, Blaser F, Zweifel SA. Real-world weekly efficacy analysis of faricimab in patients with age-related macular degeneration. Bioengineering. 2024;11:478.
CAS PubMed PubMed Central Google Scholar
Ibrahim FNI, Teo KYC, Tan T-E, Chan HH, Chandrasekaran PR, Lee S-Y, et al. Initial experiences of switching to faricimab for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in an Asian population. Front Ophthalmol. 2024;3:1346322.
Takahashi H, Inoda S, Takahashi H, Takahashi R, Hashimoto Y, Yoshida H, et al. One-year visual and anatomical outcomes of intravitreal faricimab injection for neovascular age-related macular degeneration after prior brolucizumab treatment. Sci Rep. 2024;14:9087.
CAS PubMed PubMed Central Google Scholar
Amoaku WM, Chakravarthy U, Gale R, Gavin M, Ghanchi F, Gibson J, et al. Defining response to anti-VEGF therapies in neovascular AMD. Eye. 2015;29:721–31.
CAS PubMed PubMed Central Google Scholar
Kataoka K, Itagaki K, Hashiya N, Wakugawa S, Tanaka K, Nakayama M, et al. Six-month outcomes of switching from aflibercept to faricimab in refractory cases of neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2024;262:43–51.
Chi S-C, Weng C-C, Chen S-J, Lin T-C, Chou Y-B, Hwang D-K. The Short-Term Efficacy and Safety of Faricimab in Refractory Neovascular Age-Related Macular Degeneration: The Real-World Experience in Taiwan. Ophthalmologica. 2024;247:312–21.
Goodchild C, Bailey C, Soto Hernaez J, Ahmed E, Salvatore S. Real world efficacy and durability of faricimab in patients with neovascular AMD (nAMD) who had sub-optimal response to prior anti-VEGF therapy. Eye. 2024;38:3059–64.
Cancian G, Paris A, Agliati L, Rizzato A, Clerici M, Volpe G, et al. One-year real-world outcomes of intravitreal faricimab for previously treated neovascular age-related macular degeneration. Ophthalmol Ther. 2024;13:2985–97.
PubMed PubMed Central Google Scholar
Hikichi T. Investigation of satisfaction with short-term outcomes after switching to faricimab to treat neovascular age-related macular degeneration. Jpn J Ophthalmol. 2023;67:652–6.
Borchert GA, Kiire CA, Stone NM, Akil H, Gkika T, Fischer MD, et al. Real-world six-month outcomes in patients switched to faricimab following partial response to anti-VEGF therapy for neovascular age-related macular degeneration and diabetic macular oedema. Eye. 2024;38:3569–77.
CAS PubMed PubMed Central Google Scholar
Ng B, Kolli H, Ajith Kumar N, Azzopardi M, Logeswaran A, Buensalido J, et al. Real-world data on faricimab switching in treatment-refractory neovascular age-related macular degeneration. Life. 2024;14:193.
CAS PubMed PubMed Central Google Scholar
Tamiya R, Hata M, Tanaka A, Tsuchikawa M, Ueda-Arakawa N, Tamura H, et al. Therapeutic effects of faricimab on aflibercept-refractory age-related macular degeneration. Sci Rep. 2023;13:21128.
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