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G. Derosa, P. Maffioli, A. D’Angelo, V. Foscaldi, R. Piazza, M. Mangrella, F. Fogacci, A.F.G. Cicero
Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. giuseppe.derosa@unipv.it
Prediabetes is an intermediary metabolic state marked by impaired glucose control, often preceding the development of type 2 diabetes (T2D). Early detection of prediabetes and intervention are critical to prevent the progression to T2D and its associated complications. This review examines the effects of nutraceuticals on regulating metabolism, with a focus on glucose control, specifically chromium picolinate (CrP) and banaba leaf extract. CrP has been extensively studied, and its role in regulating metabolism has been officially recognized. Preclinical research demonstrates its ability to improve glucose control by enhancing insulin sensitivity. These effects explain the reductions in fasting plasma glucose, elevated hemoglobin A1c, and insulin levels observed in clinical studies, particularly in patients with T2D. Banaba (Lagerstroemia speciosa) leaf extract, rich in corosolic acid and ellagitannins, has also shown promising results in improving glycemic control. As observed in preclinical studies, both banaba extract and corosolic acid exert insulin-sensitizing, glucose-lowering, and lipid-lowering properties. Clinical trials have confirmed these effects in individuals with T2D and prediabetes. Based on this evidence, combining CrP and banaba leaf extract may offer synergistic benefits in managing dysglycemia and delaying the onset of T2D in individuals with prediabetes. Only one study has evaluated the effects of the CrP and banaba extract combination, showing positive outcomes in individuals with prediabetes. Further research is needed to corroborate these preliminary findings. In conclusion, nutraceuticals like CrP and banaba leaf extract hold promise as complementary therapies to be used alongside lifestyle modifications for individuals with prediabetes.
Graphical Abstract
G. Derosa, P. Maffioli, A. D’Angelo, V. Foscaldi, R. Piazza, M. Mangrella, F. Fogacci, A.F.G. Cicero
Exploring nutraceutical solutions for prediabetes: a narrative review on the effects of banaba and chromium picolinate
Eur Rev Med Pharmacol Sci
Year: 2025
Vol. 29 - N. 6
Pages: 324-338
DOI: 10.26355/eurrev_202506_37275
Submission date: 04 Oct 2024
Revised on: 17 Mar 2025
Accepted on: 07 May 2025
Published online: 30 Jun 2025
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