Abanades S, Peiró AM, Farré M (2004) Club drugs: Los Viejos Fármacos son Las nuevas Drogas de La fiesta. Medicina Clínica 123(8):305–311. https://doi.org/10.1016/S0025-7753(04)74499-1

Article  PubMed  Google Scholar 

Almeida CAF, Pereira-Junior AA, Rangel JG, Pereira BP, Costa KCM, Bruno V, Silveira GO, Ceron CS, Yonamine M, Camarini R, Garcia RCT, Marcourakis T, Torres LH (2022) Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. Behav Brain Res 416:113546. https://doi.org/10.1016/j.bbr.2021.113546

Blaauboer BJ (2008) The contribution of in vitro toxicity data in hazard and risk assessment: current limitations and future perspectives. Toxicol Lett 180(2):81–84. https://doi.org/10.1016/j.toxlet.2008.05.008

Article  PubMed  Google Scholar 

Bosnjak J, Yan Z, Canfield Y, Muravyeva SY, Kikuchi M, Wells CW, Corbett CA, J., Bai X (2012) Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. Curr Drug Saf 7(2):106–119. https://doi.org/10.2174/157488612802715663

Article  PubMed  PubMed Central  Google Scholar 

Brigelius-Flohé R, Maiorino M (2013) Glutathione peroxidases. Biochimica et biophysica acta (BBA) -. Gen Subj 1830(5):3289–3303. https://doi.org/10.1016/j.bbagen.2012.11.020

Article  Google Scholar 

Chen L, Chen P, Lin Z (2020) Artificial intelligence in education: A review. IEEE Access 8:75264–75278. https://doi.org/10.1109/ACCESS.2020.2988510

Article  Google Scholar 

de Bairros AV, Lanaro R, de Almeida RM, Yonamine M (2014) Determination of ketamine, Norketamine and dehydronorketamine in urine by hollow-fiber liquid-phase Microextraction using an essential oil as supported liquid membrane. Forensic Sci Int 243:47–54. https://doi.org/10.1016/j.forsciint.2014.04.016

Article  PubMed  Google Scholar 

de Oliveira CMB, Sakata RK, Issy AM, Garcia JBS (2004) Cetamina e analgesia preemptiva. Revista Brasileira De Anestesiologia 54(5). https://doi.org/10.1590/S0034-70942004000500016

Demenech LM, Dumith SC, Gramajo CS, Ferreira MZ, Silveira RR, Neiva-Silva L (2021) Uso de club drugs entre estudantes de graduação: prevalência, características associadas e a influência Dos Pares. Jornal Brasileiro De Psiquiatria 70(2):108–116. https://doi.org/10.1590/0047-2085000000301

Article  Google Scholar 

Donnelly RF (2013) Stability of diluted ketamine packaged in glass vials. Can J Hosp Pharm 66(3):198. https://doi.org/10.4212/cjhp.v66i3.1259

dos Santos LA, dos Santos GS, Fernandes GAB, Corrêa MF, de Faria Almeida CA, Fernandes L, Marcourakis T, Fernandes JPS, Garcia RCT (2022) Neurotoxicity assessment of 1-[(2,3-Dihydro-1-Benzofuran-2-yl)Methyl]Piperazine (LINS01 Series) derivatives and their protective effect on Cocaine-Induced neurotoxicity model in SH-SY5Y cell culture. Neurotox Res 40(6):1653–1663. https://doi.org/10.1007/s12640-022-00601-8

Article  PubMed  Google Scholar 

Fan X, Bian W, Liu M, Li J, Wang Y (2021) MiRNA -429 alleviates ketamine‐induced neurotoxicity through targeting BAG5. Environ Toxicol 36(4):620–627. https://doi.org/10.1002/tox.23066

Article  PubMed  Google Scholar 

Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC (2018) Neuronal Cell Death Physiological Reviews 98(2):813–880. https://doi.org/10.1152/physrev.00011.2017

Galluzzi L, Blomgren K, Kroemer G (2009) Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci 10(7):481–494. https://doi.org/10.1038/nrn2665

Article  PubMed  Google Scholar 

Garcia RCT, Dati LMM, Fukuda S, Torres LHL, Moura S, de Carvalho ND, Carrettiero DC, Camarini R, Levada-Pires AC, Yonamine M, Negrini-Neto O, Abdalla FMF, Sandoval MRL, Afeche SC, Marcourakis T (2012) Neurotoxicity of Anhydroecgonine Methyl ester, a crack cocaine pyrolysis product. Toxicol Sci 128(1):223–234. https://doi.org/10.1093/toxsci/kfs140

Article  PubMed  Google Scholar 

Garcia RCT, Torres LL, Dati LMM, Loureiro APM, Afeche SC, Sandoval MRL, Marcourakis T (2019) Anhydroecgonine Methyl ester (AEME), a cocaine pyrolysis product, impairs glutathione-related enzymes response and increases lipid peroxidation in the hippocampal cell culture. Toxicol Rep 6:1223–1229. https://doi.org/10.1016/j.toxrep.2019.11.001

Article  PubMed  PubMed Central  Google Scholar 

Getachew B, Csoka AB, Garden AR, Copeland RL, Tizabi Y (2021) Sodium butyrate protects against Ethanol-Induced toxicity in SH-SY5Y cell line. Neurotox Res 39(6):2186–2193. https://doi.org/10.1007/s12640-021-00418-x

Article  PubMed  PubMed Central  Google Scholar 

Hansen HH, Briem T, Dzietko M, Sifringer M, Voss A, Rzeski W, Zdzisinska B, Thor F, Heumann R, Stepulak A, Bittigau P, Ikonomidou C (2004) Mechanisms leading to disseminated apoptosis following NMDA receptor Blockade in the developing rat brain. Neurobiol Dis 16(2):440–453. https://doi.org/10.1016/j.nbd.2004.03.013

Article  PubMed  Google Scholar 

Hernandez-Martinez J, Forrest CM, Darlington LG, Smith RA, Stone TW (2017) Quinolinic acid induces neuritogenesis in SH ‐ SY5Y neuroblastoma cells independently of NMDA receptor activation. Eur J Neurosci 45(5):700–711. https://doi.org/10.1111/ejn.13499

Article  PubMed  Google Scholar 

Ito H, Uchida T, Makita K (2015) Ketamine causes mitochondrial dysfunction in human induced pluripotent stem Cell-Derived neurons. PLoS ONE 10(5):e0128445. https://doi.org/10.1371/journal.pone.0128445

Article  PubMed  PubMed Central  Google Scholar 

Kamal H, Tan GC, Ibrahim SF, Shaikh MF, Mohamed IN, Mohamed RMP, Hamid AA, Ugusman A, Kumar J (2020) Alcohol use disorder, neurodegeneration, alzheimer’s and parkinson’s disease: interplay between oxidative stress, neuroimmune response and excitotoxicity. Front Cell Neurosci 14. https://doi.org/10.3389/fncel.2020.00282

Kobayashi NHC, Farias SV, Luz DA, Machado-Ferraro KM, da Conceição BC, Silveira CCM, da, Fernandes LMP, Cartágenes S, de Ferreira C, Fontes-Júnior VMM, E. A., Maia C (2022) do S. F. Ketamine plus Alcohol: What We Know and What We Can Expect about This. International Journal of Molecular Sciences 23(14):7800. https://doi.org/10.3390/ijms23147800

Kovalevich J, Langford D (2013) Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology. Methods Mol Biol 1078:9–21. https://doi.org/10.1007/978-1-62703-640-5_2

Article  PubMed  PubMed Central  Google Scholar 

Kutlu MG, Gould TJ (2016) Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction. Learn Mem 23(10):515–533. https://doi.org/10.1101/lm.042192.116

Lapenna D (2023) Glutathione and glutathione-dependent enzymes: from biochemistry to gerontology and successful aging. Ageing Res Rev 92:102066. https://doi.org/10.1016/j.arr.2023.102066

Article  PubMed  Google Scholar 

Laranjeira R (2014) Segundo Levantamento Nacional de Álcool e Drogas (LENAD)– 2012. Instituto Nacional de Ciência e Tecnologia para Políticas Públicas do Álcool e Outras Drogas (INPAD), UNIFESP. https://inpad.org.br/wp-content/uploads/2014/03/Lenad-II-Relat%C3%B3rio.pdf

Li Q, Wu H, Fan S, Liu D, Jiang H, Zhang Q, Pan F (2019) The effects of sub-anesthetic ketamine plus ethanol on behaviors and apoptosis in the prefrontal cortex and hippocampus of adolescent rats. Pharmacol Biochem Behav 184:172742. https://doi.org/10.1016/j.pbb.2019.172742

Article  PubMed  Google Scholar 

Mak YT, Lam WP, Lü L, Wong YW, Yew DT (2010) The toxic effect of ketamine on SH-SY5Y neuroblastoma cell line and human neuron. Microsc Res Tech 73(3):195–201. https://doi.org/10.1002/jemt.20774

Article  PubMed  Google Scholar 

MJSP M (2021) da J. e da S. P. II Relatório Brasileiro sobre Drogas MJSP Brasília 2021 Ministério da Justiça e Segurança Pública Secretaria Nacional de Políticas sobre Drogas e Gestão de Ativos. https://hdl.handle.net/11600/63030

Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1–2):55–63. https://doi.org/10.1016/0022-1759(83)90303-4

Article  PubMed  Google Scholar 

Nowacka A, Borczyk M (2019) Ketamine applications beyond anesthesia – A literature review. Eur J Pharmacol 860:172547. https://doi.org/10.1016/j.ejphar.2019.172547

Article  PubMed  Google Scholar 

Pérez MJ, Loyola R, Canelo F, Aranguiz A, Tapia-Monsalves C, Osorio-Fuentealba C, Quintanilla RA (2020) NADPH oxidase contributes to oxidative damage and mitochondrial impairment induced by acute ethanol treatment in rat hippocampal neurons. Neuropharmacology 171:108100. https://doi.org/10.1016/j.neuropharm.2020.108100

Article  PubMed  Google Scholar 

Poon HF, Abdullah L, Mullan MA, Mullan MJ, Crawford FC (2007) Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells. Neurochem Int 50(1):69–73. https://doi.org/10.1016/j.neuint.2006.06.012

Article  PubMed  Google Scholar 

Proença S, Escher I, Fischer BI, Fisher FC, Grégoire C, Hewitt S, Nicol NJ, Paini B, Kramer A, N. I (2021) Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models. Toxicol Vitro: Int J Published Association BIBRA 73:105133. https://doi.org/10.1016/j.tiv.2021.105133

Article  Google Scholar 

Rahman I, Kode A, Biswas SK (2006) Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 1(6):3159–3165. https://doi.org/10.1038/nprot.2006.378

Article  PubMed  Google Scholar 

Rao PSS, Bell RL, Engleman EA, Sari Y (2015) Targeting glutamate uptake to treat alcohol use disorders. Front NeuroSci 9. https://doi.org/10.3389/fnins.2015.00144

Rigg N, Abu-Hijleh FA, Patel V, Mishra RK (2022) Ketamine-induced neurotoxicity is mediated through Endoplasmic reticulum stress in vitro in STHdhQ7/Q7 cells. Neurotoxicology 91:321–328. https://doi.org/10.1016/j.neuro.2022.06.004

Article  PubMed  Google Scholar 

Samantaray S, Patel KS, Knaryan VH, Thakore NP, Roudabush S, Heissenbuttle JH, Becker HC, Banik NL (2013) Calpain Inhibition prevents ethanol-induced alterations in spinal motoneurons. Neurochem Res 38(8):1734–1741. https://doi.org/10.1007/s11064-013-1077-1

Article  PubMed