Dysregulation of Mitochondrial Iron Regulators as a Basis of Iron-Mediated Retinal Degeneration in Rats

Acquaviva F, Castaldo I, Filla A et al (2008) Recombinant human erythropoietin increases frataxin protein expression without increasing mRNA expression. Cerebellum 7:360–365. https://doi.org/10.1007/s12311-008-0036-x

Article  CAS  Google Scholar 

Ajioka RS, Phillips JD, Kushner JP (2006) Biosynthesis of Heme in mammals. Biochim Biophys Acta 1763:723–736. https://doi.org/10.1016/j.bbamcr.2006.05.005

Article  PubMed  CAS  Google Scholar 

Bencze KZ, Kondapalli KC, Cook JD et al (2006) The structure and function of frataxin. Crit Rev Biochem Mol Biol 41:269–291. https://doi.org/10.1080/10409230600846058

Article  PubMed  PubMed Central  CAS  Google Scholar 

Biesemeier A, Yoeruek E, Eibl O, Schraermeyer U (2015) Iron accumulation in bruch’s membrane and melanosomes of donor eyes with age-related macular degeneration. Exp Eye Res 137:39–49. https://doi.org/10.1016/j.exer.2015.05.019

Article  CAS  Google Scholar 

Bringmann A, Pannicke T, Grosche J et al (2006) Müller cells in the healthy and diseased retina. Prog Ret Eye Res 25:397–424. https://doi.org/10.1016/j.preteyeres.2006.05.003

Article  CAS  Google Scholar 

Chaudhary K, Promsote W, Ananth S et al (2018) Iron overload accelerates the progression of diabetic retinopathy in association with increased retinal Renin expression. Sci Rep 8:3025. https://doi.org/10.1038/s41598-018-21276-2

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen C, Chen J, Wang Y et al (2021) Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance. J Biol Chem 296. https://doi.org/10.1074/jbc.ra120.015779

Article  Google Scholar 

Chen Y, Guo X, Zeng Y et al (2023) Oxidative stress induces mitochondrial iron overload and ferroptotic cell death. Sci Rep 13:15515. https://doi.org/10.1038/s41598-023-42760-4

Article  PubMed  PubMed Central  CAS  Google Scholar 

Condò I, Ventura N, Malisan F et al (2006) A pool of intramitochondrial frataxin that promotes cell survival. J Biol Chem 281:16750–16756. https://doi.org/10.1074/jbc.M511960200

Article  PubMed  CAS  Google Scholar 

Corsi B, Cozzi A, Arosio P et al (2002) Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism. J Biol Chem 277:22430–22437. https://doi.org/10.1074/jbc.M105372200

Article  PubMed  CAS  Google Scholar 

Dong X, Zhang Z, Yu N et al (2023) A novel role of ARA70 in regulating ferritinophagy of RGCs during retinal ischemia reperfusion. DNA Cell Biol 42:668–679. https://doi.org/10.1089/dna.2023.0077

Article  PubMed  CAS  Google Scholar 

Doonan F, Donovan M, Cotter TG (2003) Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci 23:5723–5731. https://doi.org/10.1523/JNEUROSCI.23-13-05723.2003

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dunaief JL (2006) Iron-induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan lecture. Invest Ophthalmol Vis Sci 47:4660–4664. https://doi.org/10.1167/iovs.06-0568

Article  PubMed  Google Scholar 

Eells JT (2019) Mitochondrial dysfunction in the aging retina. Biology 8:31. https://doi.org/10.3390/biology8020031

Article  PubMed  PubMed Central  CAS  Google Scholar 

Efimova MG, Trottier Y (2010) Distribution of frataxin in the eye retina of normal mice and of Transgenic R7E mice with retinal degeneration. J Evol Biochem Physiol 46:347–349

Article  CAS  Google Scholar 

Gnana-Prakasam JP, Martin PM, Smith SB, Ganapathy V (2010) Expression and function of iron-regulatory proteins in retina. IUBMB Life 62:363–370. https://doi.org/10.1002/iub.326

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gnana-Prakasam JP, Tawfik A, Romej M et al (2012) Iron-mediated retinal degeneration in haemojuvelin-knockout mice. Biochem J 441:599–608. https://doi.org/10.1042/BJ20111148

Article  PubMed  CAS  Google Scholar 

Green WR (1999) Histopathology of age-related macular degeneration. Mol Vis 5:27

PubMed  CAS  Google Scholar 

Guo M, Zhu Y, Shi Y et al (2022) Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies. Redox Biol 58:102541. https://doi.org/10.1016/j.redox.2022.102541

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gupta CL, Nag TC, Jha KA et al (2020) Changes in the inner retinal cells after intense and constant light exposure in Sprague-Dawley rats. Photochem Photobiol 96:1061–1073. https://doi.org/10.1111/php.13244

Article  PubMed  CAS  Google Scholar 

Hadziahmetovic M, Dentchev T, Song Y et al (2008) Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol Vis Sci 49:2728–2736. https://doi.org/10.1167/iovs.07-1472

Article  PubMed  Google Scholar 

Hadziahmetovic M, Song Y, Ponnuru P et al (2011) Age-dependent retinal iron accumulation and degeneration in Hepcidin knockout mice. Invest Ophthalmol Vis Sci 52:109–118. https://doi.org/10.1167/iovs.10-6113

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hahn P, Milam AH, Dunaief JL (2003) Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and bruch’s membrane. Arch Ophthalmol 121:1099–1105. https://doi.org/10.1001/archopht.121.8.1099

Article  PubMed  Google Scholar 

Hahn P, Qian Y, Dentchev T et al (2004) Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc Natl Acad Sci USA 101:13850–13855. https://doi.org/10.1073/pnas.0405146101

Article  PubMed  PubMed Central  CAS  Google Scholar 

Halliwell B, Gutteridge JM (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1–85. https://doi.org/10.1016/0076-6879(90)86093-b

Article  PubMed  CAS  Google Scholar 

Hao X-D, Xu W-H, Zhang X, Xue J (2024) Targeting ferroptosis: a novel therapeutic strategy for the treatment of retinal diseases. Front Pharmacol 15:14899877. https://doi.org/10.3389/fphar.2024.1489877

Article  CAS  Google Scholar 

He X, Hahn P, Iacovelli J et al (2007) Iron homeostasis and toxicity in retinal degeneration. Prog Retin Eye Res 26:649–673. https://doi.org/10.1016/j.preteyeres.2007.07.004

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hippert C, Graca AB, Barber AC et al (2015) Müller glia activation in response to inherited retinal degeneration is highly varied and Disease-Specific. PLoS ONE 10:e0120415. https://doi.org/10.1371/journal.pone.0120415

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang ML-H, Lane DJR, Richardson DR (2011) Mitochondrial mayhem: the mitochondrion as a modulator of iron metabolism and its role in disease. Antioxid Redox Signal 15:3003–3019. https://doi.org/10.1089/ars.2011.3921

Article  PubMed  CAS 

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