Pasta S, Gentile G, Raffa GM, Bellavia D, Chiarello G, Liotta R, Luca A, Scardulla C, Pilato M. In silico shear and intramural stresses are linked to aortic valve morphology in dilated ascending aorta. Eur J Vasc Endovasc Surg. 2017;54(2):254–63.

Article  CAS  PubMed  Google Scholar 

Pasta S, Phillippi JA, Tsamis A, D’Amore A, Raffa GM, Pilato M, Scardulla C, Watkins SC, Wagner WR, Gleason TG, Vorp DA. Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters. Med Eng Phys. 2016;38(2):121–30.

Article  PubMed  Google Scholar 

Korneva A, Humphrey JD. Maladaptive aortic remodeling in hypertension associates with dysfunctional smooth muscle contractility. Am J Physiol Heart Circ Physiol. 2019;316(2):H265–78.

Article  CAS  PubMed  Google Scholar 

Della Corte A, Lo Presti F, Saade W, Rubino AS, Palmieri L, Patanè F, Miraldi F, De Feo M. Acute type A aortic dissection in bicuspid versus tricuspid aortic valve patients: focus on geometrical features of the aorta. Eur J Cardiothorac Surg. 2023;63(2):ezac576.

Article  PubMed  Google Scholar 

Wu J, Zafar MA, Li Y, Saeyeldin A, Huang Y, Zhao R, Qiu J, Tanweer M, Abdelbaky M, Gryaznov A, Buntin J, Ziganshin BA, Mukherjee SK, Rizzo JA, Yu C, Elefteriades JA. Ascending aortic length and risk of aortic adverse events: the neglected dimension. J Am Coll Cardiol. 2019;74(15):1883–94.

Article  PubMed  Google Scholar 

Vizzardi E, Maffessanti F, Lorusso R, Sciatti E, Bonadei I, Gelsomino S, Metra M, Pepi M. Ascending aortic dimensions in hypertensive subjects: reference values for two-dimensional echocardiography. J Am Soc Echocardiogr. 2016;29(9):827–37.

Article  PubMed  Google Scholar 

Mori M, Gan G, Deng Y, Yousef S, Weininger G, Daggula KR, Agarwal R, Shang M, Assi R, Geirsson A, Vallabhajosyula P. Development and validation of a predictive model to identify patients with an ascending thoracic aortic aneurysm. J Am Heart Assoc. 2021;10(22):e022102.

Article  PubMed  PubMed Central  Google Scholar 

Suzuki T, Isselbacher EM, Nienaber CA, Pyeritz RE, Eagle KA, Tsai TT, Cooper JV, Januzzi JL Jr, Braverman AC, Montgomery DG, Fattori R, Pape L, Harris KM, Booher A, Oh JK, Peterson M, Ramanath VS, Froehlich JB. Type-selective benefits of medications in treatment of acute aortic dissection from the International Registry of Acute Aortic Dissection (IRAD). Am J Cardiol. 2012;109:122–7.

Article  CAS  PubMed  Google Scholar 

Kobeissi E, Hibino M, Pan H, Aune D. Blood pressure, hypertension and the risk of abdominal aortic aneurysms: a systematic review and meta-analysis of cohort studies. Eur J Epidemiol. 2019;34(6):547–55.

Article  PubMed  PubMed Central  Google Scholar 

Canciello G, Mancusi C, Izzo R, Morisco C, Strisciuglio T, Barbato E, Trimarco B, Luca N, de Simone G, Losi MA. Determinants of aortic root dilatation over time in patients with essentialhHypertension: the Campania Salute Network. Eur J Prev Cardiol. 2021;28(13):1508–14.

Article  PubMed  Google Scholar 

de Simone G, Roman MJ, De Marco M, Bella JN, Izzo R, Lee ET, Devereux RB. Hemodynamic correlates of abnormal aortic root dimension in an adult population: the Strong Heart Study. J Am Heart Assoc. 2015;4(10): e002309.

Article  PubMed  PubMed Central  Google Scholar 

Lønnebakken MT, Izzo R, Mancusi C, Losi MA, Stabile E, Rozza F, Gerdts E, Trimarco B, de Luca N, de Simone G. Aortic root dimension and arterial stiffness in arterial hypertension: the Campania Salute Network. J Hypertens. 2016;34(6):1109–14.

Article  PubMed  Google Scholar 

Isselbacher EM, Preventza O, Hamilton Black J, Augoustides JG, Beck AW, Bolen MA. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology joint committee on clinical practice guidelines. Circulation. 2022;146(24):e334–482.

Article  PubMed  Google Scholar 

Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwöger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints CJ. 2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. Eur Heart J. 2014;35(41):2873–926.

Article  PubMed  Google Scholar 

Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension. 2001;38(3):581–7.

Article  CAS  PubMed  Google Scholar 

Renna NF, de Las Heras N, Miatello RM. Pathophysiology of vascular remodeling in hypertension. Vol. Int J Hypertens. 2013;2013: 808353.

Mammoto A, Matus K, Mammoto T. Extracellular matrix in aging aorta. Front Cell Dev Biol. 2022;10:822561.

Article  PubMed  PubMed Central  Google Scholar 

Humphrey JD. Mechanisms of vascular remodeling in hypertension. Am J Hypertens. 2021;34(5):432–41.

Article  PubMed  Google Scholar 

Schoenhagen P, Tuzcu EM, Apperson-Hansen C, Wang C, Wolski K, Lin S, Sipahi I, Nicholls SJ, Magyar WA, Loyd A, Churchill T, Crowe T, Nissen SE. Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial. Circulation. 2006;113(24):2826–34.

Article  CAS  PubMed  Google Scholar 

Jaminon A, Reesink K, Kroon A, Schurgers L. The Role of vascular smooth muscle cells in arterial remodeling: focus on calcification-related processes. Int J Mol Sci. 2019;20(22):5694.

Article  CAS  PubMed  PubMed Central  Google Scholar 

London GM, Pannier B, Safar ME. Arterial stiffness gradient, systemic reflection coefficient, and pulsatile pressure wave transmission in essential hypertension. Hypertension. 2019;74(6):1366–72.

Article  CAS  PubMed  Google Scholar 

Climie RE, Alastruey J, Mayer CC, Schwarz A, Laucyte-Cibulskiene A, Voicehovska J, Bianchini E, Bruno RM, Charlton PH, Grillo A, Guala A, Hallab M, Hametner B, Jankowski P, Königstein K, Lebedeva A, Mozos I, Pucci G, Puzantian H, Terentes-Printzios D, et al. Vascular ageing: moving from bench towards bedside. Eur J Prev Cardiol. 2023;30(11):1101–17.

Article  PubMed  PubMed Central  Google Scholar 

Lembo M, Pacella D, Manzi MV, Morisco C, La Mura L, Mancusi C, Bardi L, Trimarco V, Trimarco B, Izzo R, Esposito G. Hypertension-mediated organ damage involving multiple sites is an independent risk factor for cardiovascular events. Eur Heart J Open. 2023;3(5):oead102.

Article  PubMed  PubMed Central  Google Scholar 

Bruno RM, Nilsson PM, Engström G, Wadström BN, Empana JP, Boutouyrie P, Laurent S. Early and supernormal vascular aging: clinical characteristics and association with incident cardiovascular events. Hypertension. 2020;76(5):1616–24.

Article  CAS  PubMed  Google Scholar 

Boutouyrie P, Chowienczyk P, Humphrey JD, Mitchell GF. Arterial stiffness and cardiovascular risk in hypertension. Circ Res. 2021;128(7):864–86.

Article  CAS  PubMed  Google Scholar 

Lam CS, Xanthakis V, Sullivan LM, Lieb W, Aragam J, Redfield MM, Mitchell GF, Benjamin EJ, Vasan RS. Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study. Circulation. 2010;122(9):884–90.

Article  PubMed  PubMed Central  Google Scholar 

Patel HN, Miyoshi T, Addetia K, Citro R, Daimon M, Gutierrez Fajardo P, Kasliwal RR, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Ronderos RE, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Tude Rodrigues AC, Amuthan V, Zhang Y. Normal values of aortic root size according to age, sex, and race: results of the World Alliance of Societies of Echocardiography Study. J Am Soc Echocardiogr. 2022;35(3):267–74.

Article  PubMed  Google Scholar 

Kilanowski-Doroh IM, McNally AB, Wong TJ, Visniauskas B, Blessinger SA, Imulinde Sugi A, Richard C, Diaz Z, Horton AC, Natale CA, Ogola BO, Lindsey SH. Ovariectomy-induced arterial stiffening differs from vascular aging and is reversed by GPER Activation. Hypertension. 2024;81(5):e51–62.

CAS  PubMed  Google Scholar 

Teixido-Tura G, Almeida AL, Choi EY, Gjesdal O, Jacobs DR Jr, Dietz HC, Liu K, Sidney S, Lewis CE, Garcia-Dorado D, Evangelista A, Gidding S, Lima JA. Determinants of aortic root dilatation and reference values among young adults over a 20-year period: coronary artery risk development in young adults study. Hypertension. 2015;66(1):23–9.

Article  CAS  PubMed  Google Scholar 

Norman PE, Curci JA. Understanding the effects of tobacco smoke on the pathogenesis of aortic aneurysm. Arterioscler Thromb Vasc Biol. 2013;33(7):1473–7.

Article  CAS  PubMed