Sodium benzoate may reduce appetite in Drosophila melanogaster through serotonin upregulation

Chazelas E, Deschasaux M, Srour B, Kesse-Guyot E, Julia C, Alles B, Druesne-Pecollo N, Galan P, Hercberg S, Latino-Martel P, Esseddik Y. Food additives: distribution and co-occurrence in 126,000 food products of the French market. Sci Rep. 2020;10(1):3980. https://doi.org/10.1038/s41598-020-60948-w

Toth B. Lack of tumorigenicity of sodium benzoate in mice. Toxicol Sci. 1984;4(3):494-6. DOI: 10.1016/0272-0590(84)90208-2. https://doi.org/10.1016/0272-0590(84)90208-2

Nair B. Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate. Int J Toxicol. 2001;20:23-50. https://doi.org/10.1080/10915810152630729

Batshaw ML, Hyman SL, Coyle JT, Robinson MB, Qureshi IA, David Mellits E, Quaskey S. Effect of sodium benzoate and sodium phenylacetate on brain serotonin turnover in the ornithine transcarbamylase-deficient sparse-fur mouse. Pediatr Res. 1988;23(4):368-74. https://doi.org/10.1203/00006450-198804000-00006

Maier E, Kurz K, Jenny M, Schennach H, Ueberall F, Fuchs D. Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro. Food Chem Toxicol. 2010;48(7):1950-6. https://doi.org/10.1016/j.fct.2010.04.042

Muneer A. Kynurenine pathway of tryptophan metabolism in neuropsychiatric disorders: pathophysiologic and therapeutic considerations. Clin Psychopharmacol Neurosci. 2020;18(4):507. https://doi.org/10.9758/cpn.2020.18.4.507

Castro-Portuguez R, Sutphin GL. Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan. Exp Gerontol.. 2020;132:110841. https://doi.org/10.1016/j.exger.2020.110841

Nas JS, Medina PM. Upregulation of serotonin by sodium benzoate and sodium metabisulfite may activate caloric restriction which could enhance longevity and cognition. Med Hypotheses. 2023;178:111120. https://doi.org/10.1016/j.mehy.2023.111120

Bernardo MC, Santos CE, Mabalot ME, Nas JS. Petunidin-3-glucoside supplementation causes sex-specific effects on the lifespan and motor function in Drosophila melanogaster. Acad J Biol. 2024;46(1):1-2. https://doi.org/10.15625/2615-9023/19103

Nas JS, Medina PM. Delphinidin-3-glucoside prolongs lifespan and healthspan in Caenorhabditis elegans with and without environmental stress. J Appl Pharm Sci. 2024;14(1):108-13. https://doi.org/10.7324/JAPS.2024.141494

Diegelmann S, Jansen A, Jois S, Kastenholz K, Escarcena LV, Strudthoff N, Scholz H. The CApillary FEeder assay measures food intake in Drosophila melanogaster. J Vis Exp. 2017;121:e55024. https://doi.org/10.3791/55024

Nas JS, Medina PM. Cyanidin-3-glucoside promotes longevity and tolerance against UVA and oxidative stress in Caenorhabditis elegans. Explore Anim Med Res. 2023;13:105-110. https://doi.org/10.52635/eamr/13.1.105-110

Nas JS, Manalo RV, Medina PM. Peonidin-3-glucoside extends the lifespan of Caenorhabditis elegans and enhances its tolerance to heat, UV, and oxidative stresses. Sci Asia. 2021;47(4). https://doi.org/10.2306/scienceasia1513-1874.2021.059

Doringo JA, Gapayao KR, Medina PM, Nas JS. Cyanidin-3-glucoside Enhances Longevity and Heat Stress Resilience in Drosophila melanogaster. Biomed Biotechnol Res J. 2023;7(4):537-44. https://doi.org/10.4103/bbrj.bbrj_194_23

Pedroso AD, Nussio LG, Barioni Júnior W, Rodrigues AD, Loures DR, Campos FD, Ribeiro JL, Mari LJ, Zopollatto M, Junqueira M, Schmidt P. Performance of Holstein heifers fed sugarcane silages treated with urea, sodium benzoate or Lactobacillus buchneri. Pesqui Agropecu Bras. 2006;41:649-54. https://doi.org/10.1590/S0100-204X2006000400015

Gregson RA. Determination of a gustatory L70 point for sodium benzoate. Br J Psychol. 1969;60(2):187-97. https://doi.org/10.1111/j.2044-8295.1969.tb01191.x

Ciardi C, Jenny M, Tschoner A, Ueberall F, Patsch J, Pedrini M, Ebenbichler C, Fuchs D. Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro. Br J Nutr. 2012;107(6):826-33. https://doi.org/10.1017/S0007114511003680

Lennerz BS, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, Mootha VK. Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. Mol Genet Metab. 2015;114(1):73-9. https://doi.org/10.1016/j.ymgme.2014.11.010

Benli D, Türkoğlu Ş. The effect of some food preservatives on percentage of survival and longevity in Drosophila melanogaster. Cumhuriyet Sci J. 2017;38(3):461-72. https://doi.org/10.17776/csj.340486

Dong Y, Ding Z, Song L, Zhang D, Xie C, Zhang S, Feng L, Liu H, Pang Q. Sodium benzoate delays the development of Drosophila melanogaster larvae and alters commensal microbiota in adult flies. Front Microbiol. 2022;13:911928. https://doi.org/10.3389/fmicb.2022.911928

Asejeje FO, Alade TF, Oyibo A, Abolaji AO. Toxicological assessment of sodium benzoate in Drosophila melanogaster. J Biochem Mol Toxicol. 2024;38(1):e23586. https://doi.org/10.1002/jbt.23586

Pardo R, Velilla M, Herrero L, Cervela L, Ribeiro ML, Simó R, Villena JA. Calorie restriction and SIRT1 overexpression induce different gene expression profiles in white adipose tissue in association with metabolic improvement. Mol Nutr Food Res. 2021;65(9):2000672. https://doi.org/10.1002/mnfr.202000672

Chiappelli J, Pocivavsek A, Nugent KL, Notarangelo FM, Kochunov P, Rowland LM, Schwarcz R, Hong LE. Stress-induced increase in kynurenic acid as a potential biomarker for patients with schizophrenia and distress intolerance. JAMA Psych. 2014;71(7):761-8. https://doi.org/10.1001/jamapsychiatry.2014.243

Tecott LH. Serotonin and the orchestration of energy balance. Cell Metab. 2007;6(5):352-61. https://doi.org/10.1016/j.cmet.2007.09.012

Nas JS. Exploring the binding affinity and non-covalent interactions of anthocyanins with aging-related enzymes through molecular docking. Phil J Health Res Dev. 2020;24(3):9-19.

Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J. SirT1 regulates energy metabolism and response to caloric restriction in mice. PloS One. 2008;3(3):e1759. https://doi.org/10.1371/journal.pone.0001759

Ramadori G, Lee CE, Bookout AL, Lee S, Williams KW, Anderson J, Elmquist JK, Coppari R. Brain SIRT1: anatomical distribution and regulation by energy availability. J Neurosci. 2008;28(40):9989-96. https://doi.org/10.1523/JNEUROSCI.3257-08.2008

Comments (0)

No login
gif