Association of a Body Shape Index with Bone Mineral Density and Osteoporosis Among U.S. Adults: Evidence from NHANES

Duggan SN, Purcell C, Kilbane M, O’Keane M, McKenna M, Gaffney P, Ridgway PF, Boran G, Conlon KC (2015) An association between abnormal bone turnover, systemic inflammation, and osteoporosis in patients with chronic pancreatitis: a case-matched study. Am J Gastroenterol 110:336–345

Article  CAS  PubMed  Google Scholar 

Gnudi S, Sitta E, Lisi L (2009) Relationship of body mass index with main limb fragility fractures in postmenopausal women. J Bone Miner Metab 27:479–484

Article  PubMed  Google Scholar 

Center JR (2017) Fracture burden: what two and a half decades of Dubbo osteoporosis epidemiology study data reveal about clinical outcomes of osteoporosis. Curr Osteoporos Rep 15:88–95

Article  PubMed  Google Scholar 

Kaze AD, Rosen HN, Paik JM (2018) A meta-analysis of the association between body mass index and risk of vertebral fracture. Osteoporos Int 29:31–39

Article  CAS  PubMed  Google Scholar 

Briggs AM, Cross MJ, Hoy DG, Sanchez-Riera L, Blyth FM, Woolf AD, March L (2016) Musculoskeletal health conditions represent a global threat to healthy aging: a report for the 2015 World Health Organization world report on ageing and health. Gerontologist 56(Suppl 2):S243–S255

Article  PubMed  Google Scholar 

Zhang X, Zhang J, Shang Z, Duan Y, Du Y, Kan B, Yang S (2024) Linear and non-linear relationships between body fat mass distribution and bone mineral density in adults: the NHANES, 2011–2018. Prev Med 186:108092

Article  PubMed  Google Scholar 

Bim MA, Pinto AA, de Angelo H, Gonzaga I, Guimaraes A, Felden E, de Carvalho W, Hind K, Pelegrini A (2022) Relationship between body composition and bone mass in normal-weight and overweight adolescents. PeerJ 10:e14108

Article  PubMed  PubMed Central  Google Scholar 

Lopez-Peralta S, Romero-Velarde E, Vasquez-Garibay EM, Gonzalez-Hita M, Robles-Robles LC, Ruiz-Gonzalez FJ, Perez-Romero MA (2022) Bone mineral density and body composition in normal weight, overweight and obese children. BMC Pediatr 22:249

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pinar-Gutierrez A, Garcia-Fontana C, Garcia-Fontana B, Munoz-Torres M (2022) Obesity and bone health: a complex relationship. Int J Mol Sci 23

Jain RK, Vokes T (2023) Visceral adipose tissue is negatively associated with bone mineral density in NHANES 2011–2018. J Endocr Soc 7:8

Article  Google Scholar 

Thomas DM, Bredlau C, Bosy-Westphal A, Mueller M, Shen W, Gallagher D, Maeda Y, McDougall A, Peterson CM, Ravussin E, Heymsfield SB (2013) Relationships between body roundness with body fat and visceral adipose tissue emerging from a new geometrical model. Obesity (Silver Spring) 21:2264–2271

Article  PubMed  Google Scholar 

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SJ (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645

Article  CAS  PubMed  Google Scholar 

Rico-Martin S, Calderon-Garcia JF, Sanchez-Rey P, Franco-Antonio C, Martinez AM, Sanchez MJ (2020) Effectiveness of body roundness index in predicting metabolic syndrome: A systematic review and meta-analysis. Obes Rev 21:e13023

Article  PubMed  Google Scholar 

Vecchie A, Dallegri F, Carbone F, Bonaventura A, Liberale L, Portincasa P, Fruhbeck G, Montecucco F (2018) Obesity phenotypes and their paradoxical association with cardiovascular diseases. Eur J Intern Med 48:6–17

Article  PubMed  Google Scholar 

Wang X, Yang S, He G, Xie L (2023) The association between weight-adjusted-waist index and total bone mineral density in adolescents: NHANES 2011–2018. Front Endocrinol (Lausanne) 14:1191501

Article  PubMed  Google Scholar 

Krakauer NY, Krakauer JC (2012) A new body shape index predicts mortality hazard independently of body mass index. PLoS ONE 7:e39504

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagayama D, Fujishiro K, Watanabe Y, Yamaguchi T, Suzuki K, Saiki A, Shirai K (2022) A body shape index (ABSI) as a variant of conicity index not affected by the obesity paradox: a cross-sectional study using arterial stiffness parameter. J Pers Med 12

Kanis JA (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group Osteoporos Int 4:368–381

Article  CAS  Google Scholar 

Looker AC, Orwoll ES, Johnston CJ, Lindsay RL, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP (1997) Prevalence of low femoral bone density in older U.S. adults from NHANES III. J Bone Miner Res 12:1761–1768

Article  CAS  PubMed  Google Scholar 

Looker AC, Borrud LG, Hughes JP, Fan B, Shepherd JA, Melton LR (2012) Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: United States, 2005–2008. Vital Health Stat 11:1–132

Google Scholar 

Pan R, Wang R, Zhang Y, Ji H, Liang X, Zhao Y (2024) The association of waist circumference with bone mineral density and risk of osteoporosis in US adult: National health and nutrition examination survey. Bone 185:117134

Article  PubMed  Google Scholar 

Guo W, Song Y, Sun Y, Du H, Cai Y, You Q, Fu H, Shao L (2022) Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: Evidence from NHANES 2011–2018. Front Endocrinol (Lausanne) 13:1071465

Article  PubMed  Google Scholar 

Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M (2011) Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378:815–825

Article  PubMed  Google Scholar 

Wang Y, Li Z, He J, Zhao Y (2024) Quercetin regulates lipid metabolism and fat accumulation by regulating inflammatory responses and glycometabolism pathways: a review. Nutrients 16

Yuen M (2023) Health complications of obesity: 224 obesity-associated comorbidities from a mechanistic perspective. Gastroenterol Clin North Am 52:363–380

Article  PubMed  Google Scholar 

Felson DT, Zhang Y, Hannan MT, Anderson JJ (1993) Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res 8:567–573

Article  CAS  PubMed  Google Scholar 

Khosla S, Atkinson EJ, Riggs BL, Melton LR (1996) Relationship between body composition and bone mass in women. J Bone Miner Res 11:857–863

Article  CAS  PubMed  Google Scholar 

Vijay J, Gauthier MF, Biswell RL, Louiselle DA, Johnston JJ, Cheung WA, Belden B, Pramatarova A, Biertho L, Gibson M, Simon MM, Djambazian H, Staffa A, Bourque G, Laitinen A, Nystedt J, Vohl MC, Fraser JD, Pastinen T, Tchernof A, Grundberg E (2020) Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. Nat Metab 2:97–109

Article  PubMed  Google Scholar 

Guerrero-Romero F, Castellanos-Juarez FX, Salas-Pacheco JM, Morales-Gurrola FG, Salas-Leal AC, Simental-Mendia LE (2023) Association between the expression of TLR4, TLR2, and MyD88 with low-grade chronic inflammation in individuals with metabolically healthy obesity. Mol Biol Rep 50:4723–4728

Article  CAS  PubMed  Google Scholar 

Duncan RL, Turner CH (1995) Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int 57:344–358

Article  CAS  PubMed  Google Scholar 

Hla MM, Davis JW, Ross PD, Wasnich RD, Yates AJ, Ravn P, Hosking DJ, McClung MR (1996) A multicenter study of the influence of fat and lean mass on bone mineral content: evidence for differences in their relative influence at major fracture sites. Early Postmenopausal Intervention Cohort (EPIC) Study Group. Am J Clin Nutr 64:354–360

Article  CAS  PubMed  Google Scholar 

Fischer V, Haffner-Luntzer M (2022) Interaction between bone and immune cells: implications for postmenopausal osteoporosis. Semin Cell Dev Biol 123:14–21

Article  PubMed  Google Scholar 

Luo X, Guo L, Xie H, Yuan L, Wu X, Zhou H, Liao E (2006) Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res 21:1648–1656

Article  CAS  PubMed  Google Scholar 

Lamghari M, Tavares L, Camboa N, Barbosa MA (2006) Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts. J Cell Biochem 98:1123–1129

Article  CAS  PubMed  Google Scholar 

Seimon RV, Wild-Taylor AL, Keating SE, McClintock S, Harper C, Gibson AA, Johnson NA, Fernando HA, Markovic TP, Center JR, Franklin J, Liu PY, Grieve SM, Lagopoulos J, Caterson ID, Byrne NM, Sainsbury A (2019) Effect of weight loss via severe vs moderate energy restriction on lean mass and body composition among postmenopausal women with obesity: the TEMPO diet randomized clinical trial. JAMA Netw Open 2:e1913733

Comments (0)

No login
gif