Keywords

Antioxidant,Pharmacokinetics,Chalcones,Pyrazolines

How to Cite

(1)

Kerek, A. L.; Kozan , L.; Schamne Fonseca , G.; Sartori dos Santos , B.; Pereira Guaringue , R.; Sens, L.; Celânia Fiorin , B. A Study of Antioxidant Properties and a Pharmacokinetic Investigation of Chalcones and Pyrazolines. Orbital: Electron. J. Chem. 2025, 17, 234-240.

Abstract

Antioxidant compounds are widely studied in the literature because they minimize oxidative damage in biological processes. In this context, chalcones and pyrazolines are considered prototype compounds for this purpose. This study describes the synthesis and characterization of seven compounds, including chalcones and pyrazolines, which were evaluated for their antioxidant power and pharmacokinetic properties. Compound 2b, a pyrazoline with a para-substituted hydroxyl group, exhibited greater antioxidant activity compared to the other compounds in the study, thus showing good potential for future applications in biological activities.