Document Type : Research Paper

Authors

1 Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

10.22038/nmj.2025.81851.2037

Abstract

Objective(s): Scientists have been focused on finding access to the potential of different materials, incredibly natural substances. This work compared two categories of nanoscale materials based on carbon sources, including carbon quantum dots (C-QDs) and detonation nanodiamonds (DNDs).
Materials and Methods: The hydrothermally synthesized C-QDs from Salvia Hispanic L. and DNDs were compared through physicochemical tests such as ultra-violet spectrophotometry (UV-Vis), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and field emission scanning microscopy (FESEM). Then, we investigated their cytotoxicity and biocompatibility on HEK293 and HepG2 cell lines, respectively. To focus on nanoparticle biodistribution and shelf life throughout the in vivo studies of rats, C-QDs and DNDs were labeled by Technetium (99mTc) radioisotope for tracking purposes.
Results: The characterization and cytotoxicity outcomes of C-QDs and DNDs confirmed both cases' relative intrinsic similarity and non-toxicity, which also gained permission to enter the in vivo studies of rats.
Conclusion: According to biodistribution assessments, despite the slight differences between their biological properties, C-QDs, and DNDs exhibited different bioaccumulation tendencies toward organ selection.

Keywords