Joshua Jeong, Klemens J. Hertel and Yongsheng Shi Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California 92697, USA Corresponding author: yongshesuci.edu Abstract

Alternative splicing (AS) is regulated by a myriad of RNA-binding proteins (RBPs) in a coordinated manner. However, most studies characterize RBPs individually. In this issue of Genes & Development, Peyda and colleagues (doi:10.1101/gad.352105.124) revealed how the LASR complex, consisting of multiple RBPs, regulates AS by recognizing multipart sequences. Their approach may be applicable to studying the combinatorial effects of other RBPs, which is critical for cracking the splicing code.