Wu W, Löbmann K, Schnitzkewitz J, Knuhtsen A, Pedersen DS, Rades T, et al. Dipeptides as co-formers in co-amorphous systems. Eur J Pharm Biopharm. 2019;134:68–76.

Article  CAS  PubMed  Google Scholar 

Yamazaki R, Kawai S, Matsuzaki T, Kaneda N, Hashimoto S, Yokokura T, et al. Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors. Eur J Pharmacol. 1997;329:181–7.

Article  CAS  PubMed  Google Scholar 

Lee J, Lee Y, Kim J, Yoon M, Choi YW. Formulation of microemulsion systems for transdermal delivery of aceclofenac. Arch Pharm Res. 2005;28(9):1097–102

Singh P, Roberts MS. Skin permeability and local tissue concentrations of nonsteroidal anti- inflammatory drugs after topical application. J Pharmacol Exp Ther. 1994;268:144–51.

CAS  PubMed  Google Scholar 

Cevc G, Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers. Transfersomes Biochim Biophys Acta - Biomembr. 2001;1514:191–205.

Article  CAS  Google Scholar 

Yong CS, Oh YK, Kyung HL, Park SM, Park YJ, Young SG, et al. Trials of clear aceclofenac-loaded soft capsules with accelerated oral absorption in human subjects. Int J Pharm. 2005;302:78–83.

Article  CAS  PubMed  Google Scholar 

Joshi VY, Sawant MR. Study on dissolution rate enhancement of poorly water soluble drug: Contributions of solubility enhancement and relatively low micelle diffusivity. J Dispers Sci Technol. 2006;27:1141–50.

Article  CAS  Google Scholar 

Mutalik S, Anju P, Manoj K, Usha AN. Enhancement of dissolution rate and bioavailability of aceclofenac: A chitosan-based solvent change approach. Int J Pharm. 2008;350:279–90.

Article  CAS  PubMed  Google Scholar 

Yesmin F, Talukder MMU, Islam MS, Laila S, Haque T. Evaluation of Aceclofenac Loaded Agarose Beads Prepared by Ionotropic Gelation Method. Stamford J Pharm Sci. 1970;1:10–7.

Article  Google Scholar 

Setty C, Prasad DVK, Gupta VRM, Sa B. Development of fast dispersible aceclofenac tablets: Effect of functionality of superdisintegrants. Indian J Pharm Sci. 2008;70:180–5.

Article  PubMed  PubMed Central  Google Scholar 

Su M, Xia Y, Shen Y, Heng W, Wei Y, Zhang L, et al. A novel drug-drug coamorphous system without molecular interactions: Improve the physicochemical properties of tadalafil and repaglinide. RSC Adv. 2019;10:565–83.

Article  ADS  PubMed  Google Scholar 

Yarlagadda DL, Sai Krishna Anand V, Nair AR, Navya Sree KS, Dengale SJ, Bhat K. Considerations for the selection of co-formers in the preparation of co-amorphous formulations. Int J Pharm. 2021;602:120649.

Article  CAS  PubMed  Google Scholar 

Dengale SJ, Grohganz H, Rades T, Löbmann K. Recent advances in co-amorphous drug formulations. Adv Drug Deliv Rev. 2016;100:116–25. https://doi.org/10.1016/j.addr.2015.12.009.

Jensen KT, Löbmann K, Rades T, Grohganz H. Improving co-amorphous drug formulations by the addition of the highly water soluble amino acid. Proline Pharmaceutics. 2014;6:416–35.

Article  CAS  Google Scholar 

Löbmann K, Laitinen R, Grohganz H, Gordon KC, Strachan C, Rades T. Coamorphous drug systems: Enhanced physical stability and dissolution rate of indomethacin and naproxen. Mol Pharm. 2011;8:1919–28.

Article  PubMed  Google Scholar 

Löbmann K, Strachan C, Grohganz H, Rades T, Korhonen O, Laitinen R. Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions. Eur J Pharm Biopharm. 2012;81:159–69.

Article  PubMed  Google Scholar 

Qian S, Heng W, Wei Y, Zhang J, Gao Y. Coamorphous lurasidone hydrochloride-saccharin with charge-assisted hydrogen bonding interaction shows improved physical stability and enhanced dissolution with ph-independent solubility behavior. Cryst Growth Des. 2015;15:2920–8.

Article  CAS  Google Scholar 

Hatwar P, Pathan IB, Chishti NAH, Ambekar W. Pellets containing quercetin amino acid co-amorphous mixture for the treatment of pain: Formulation, optimization, in-vitro and in-vivo study. J Drug Deliv Sci Technol. 2021;62:102350.

Article  CAS  Google Scholar 

Liu J, Grohganz H, Löbmann K, Rades T, Hempel NJ. Co-amorphous drug formulations in numbers: Recent advances in co-amorphous drug formulations with focus on co-formability, molar ratio, preparation methods, physical stability, in vitro and in vivo performance, and new formulation strategies. Pharmaceutics. 2021;13:389.

Wu W, Löbmann K, Schnitzkewitz J, Knuhtsen A, Pedersen DS, Grohganz H, et al. Aspartame as a co-former in co-amorphous systems. Int J Pharm. 2018;549:380–7.

Article  CAS  PubMed  Google Scholar 

Kasten G, Grohganz H, Rades T, Löbmann K. Development of a screening method for co-amorphous formulations of drugs and amino acids. Eur J Pharm Sci. 2016;95:28–35.

Article  CAS  PubMed  Google Scholar 

American Cancer Society. Aspartame and cancer risk. Am Cancer Soc. 2023;1–7. Cancer.org.

Ghebre SI. Pellets: a general overview. In Ghebre-Sellassie (eds.), Pharmaceutical Pelletization Technology, Marcel Dekker Inc. New York, 1989, 1–13.

Issa MG, Ferraz HG. Intrinsic dissolution as a tool for evaluating drug solubility in accordance with the biopharmaceutics classification system. Dissolution Technol. 2011;18:6–13.

Article  CAS  Google Scholar 

Madgulkar AR, Bhalekar MR, Padalkar RR. Formulation design and optimization of novel taste masked mouth-dissolving tablets of tramadol having adequate mechanical strength. AAPS PharmSciTech. 2009;10:574–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gowda DV, Rajesh N, Moin A, Shivakumar HG, Siddaramaiah. Controlled release behaviour of nifedipine from the pellets of gelucire/microcrystalline cellulose blends. Int J PharmTech Res. 2010;2:1215–26.

CAS  Google Scholar 

Singh R, Poddar SS, Chivate A. Sintering of wax for controlling release from pellets. AAPS PharmSciTech. 2007;8:E175–83.

Mahdi HJ. Eudragit L-100 for enteric coating of hard gelatine capsules: Formulation and evaluation. Issues Biol Sci Pharm Res. 2015;3:14–20. https://doi.org/10.15739/ibspr.008.

Article  Google Scholar 

Sadeghi H, Hajhashemi V, Minaiyan M, Movahedian A, Talebi A. A study on the mechanisms involving the anti-inflammatory effect of amitriptyline in carrageenan-induced paw edema in rats. Eur J Pharmacol. 2011;667:396–401.

Article  CAS  PubMed  Google Scholar 

Winter CA, Risley EA, Nuss GW. Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs. Proc Soc Exp Biol Med. 1962;111:544–7.

Article  CAS  PubMed  Google Scholar 

Pathan IB, Jaware BP, Shelke S, Ambekar W. Curcumin loaded ethosomes for transdermal application: Formulation, optimization, in-vitro and in-vivo study. J Drug Deliv Sci Technol. 2018;44:49–57.

Article  CAS  Google Scholar 

European Medicines Agency. ICH Topic Q 1 A (R2). Stability testing of new drug substances and products. CPMP/ICH/2736/99.

Pathan IB, Munde SJ, Shelke S, Ambekar W, Mallikarjuna SC. Curcumin loaded fish scale collagen-HPMC nanogel for wound healing application: Ex-vivo and In-vivo evaluation. Int J Polym Mater Polym Biomater. 2019;68:165–74.

Article  CAS  Google Scholar 

Chavan RB, Thipparaboina R, Kumar D, Shastri NR. Co amorphous systems: A product development perspective. Int J Pharm. 2016;515(1):403–15.

Allesø M, Chieng N, Rehder S, Rantanen J, Rades T, Aaltonen J. Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical activation. J Control Release. 2009;136:45–53.

Article  PubMed  Google Scholar 

Lenz E, Jensen KT, Blaabjerg LI, Knop K, Grohganz H, Löbmann K, et al. Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacin-arginine. Eur J Pharm Biopharm. 2015;96:44–52.

Article  CAS  PubMed  Google Scholar 

Zhu S, Gao H, Babu S, Garad S. Co-amorphous formation of high-dose zwitterionic compounds with amino acids to improve solubility and enable parenteral delivery. Mol Pharm. 2018;15:97–107.

Bisrat M, Nyström C. Physicochemical aspects of drug release. VIII. The relation between particle size and surface specific dissolution rate in agitated suspensions. Int J Pharm. 1988;47:223–31.

Article  CAS  Google Scholar 

Rahim H, Sadiq A, Ullah R, Bari A, Amin F, Farooq U, et al. Formulation of aceclofenac tablets using nanosuspension as granulating agent: An attempt to enhance dissolution rate and oral bioavailability. Int J Nanomedicine. 2020;15:8999–9009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heinz A, Strachan CJ, Gordon KC, Rades T. Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy. J Pharm Pharmacol. 2009;61:971–88.

Article  CAS  PubMed  Google Scholar 

Mutalik S, Naha A, Usha AN, Ranjith AK, Musmade P, Manoj K, et al. Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac. Arch Pharm Res. 2007;30:222–34.

Article  CAS  PubMed  Google Scholar 

Ueda H, Muranushi N, Sakuma S, Ida Y, Endoh T, Kadota K, et al. A Strategy for Co-former Selection to Design Stable Co-amorphous Formations Based on Physicochemical Properties of Non-steroidal Inflammatory Drugs. Pharm Res. 2016;33:1018–29.

Article  CAS  PubMed  Google Scholar 

Hsieh W, Cheng W, Chen L, Lin S. Non-isothermal dehydration kinetic study of aspartame hemihydrate using DSC, TGA and DSC-FTIR microspectroscopy. Asian J Pharm Sci. 2018;13:212–9.

Article  PubMed  Google Scholar 

El-Shattawy HH, Kildsig DO, Peck GE. Differential scanning calorimetry of aspartame-caffeine mixture. Drug Dev Ind Pharm. 1982;8:651–62.

Article  CAS  Google Scholar 

Essa EA, Balata GF. Preparation and characterization of domperidone solid dispersions. Pak J Pharm Sci. 2012;25:783–91.

CAS  PubMed  Google Scholar 

Einfal T, Planinšek O, Hrovat K. Methods of amorphization and investigation of the amorphous state. Acta Pharm. 2013;63:305–34.

Johari GP, Ram S, Astl G, Mayer E. Characterizing amorphous and microcrystall