Aime S, Bergamasco B, Casu M et al (2000) Isolation and 13C-NMR characterization of an insoluble proteinaceous fraction from substantia nigra of patients with Parkinson’s disease. Mov Disord 15:977–981. https://doi.org/10.1002/1531-8257(200009)15:5%3c977::aid-mds1032%3e3.0.co;2-q
Article CAS PubMed Google Scholar
Barrett PJ, Timothy Greenamyre J (2015) Post-translational modification of α-synuclein in Parkinson’s disease. Brain Res 1628:247–253. https://doi.org/10.1016/j.brainres.2015.06.002
Article CAS PubMed Google Scholar
Bergsland N, Zivadinov R, Schweser F et al (2019) Ventral posterior substantia nigra iron increases over 3 years in Parkinson’s disease. Mov Disord 34:1006–1013. https://doi.org/10.1002/mds.27730
Article CAS PubMed PubMed Central Google Scholar
Bharathi null, Indi SS, Rao KSJ, (2007) Copper- and iron-induced differential fibril formation in alpha-synuclein: TEM study. Neurosci Lett 424:78–82. https://doi.org/10.1016/j.neulet.2007.06.052
Bi M, Du X, Jiao Q et al (2020) α-Synuclein regulates iron homeostasis via preventing parkin-mediated DMT1 ubiquitylation in Parkinson’s disease models. ACS Chem Neurosci 11:1682–1691. https://doi.org/10.1021/acschemneuro.0c00196
Article CAS PubMed Google Scholar
Biondetti E, Santin MD, Valabrègue R et al (2021) The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson’s disease. Brain 144:3114–3125. https://doi.org/10.1093/brain/awab191
Article PubMed PubMed Central Google Scholar
Brammerloh M, Morawski M, Friedrich I et al (2021) Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry. Neuroimage 239:118255. https://doi.org/10.1016/j.neuroimage.2021.118255
Article CAS PubMed Google Scholar
Buijs M, Doan NT, van Rooden S et al (2017) In vivo assessment of iron content of the cerebral cortex in healthy aging using 7-Tesla T2*-weighted phase imaging. Neurobiol Aging 53:20–26. https://doi.org/10.1016/j.neurobiolaging.2016.09.005
Article CAS PubMed Google Scholar
Cabantchik ZI, Munnich A, Youdim MB, Devos D (2013) Regional siderosis: a new challenge for iron chelation therapy. Front Pharmacol 4:167. https://doi.org/10.3389/fphar.2013.00167
Article CAS PubMed PubMed Central Google Scholar
Cao Q, Huang J, Tang D et al (2022) Application value of multiparametric MRI for evaluating iron deposition in the substantia nigra in Parkinson’s disease. Front Neurol 13:1096966. https://doi.org/10.3389/fneur.2022.1096966
Castellani RJ, Siedlak SL, Perry G, Smith MA (2000) Sequestration of iron by Lewy bodies in Parkinson’s disease. Acta Neuropathol 100:111–114. https://doi.org/10.1007/s004010050001
Article CAS PubMed Google Scholar
Chen K, Zhang L, Mao H et al (2023) The impact of iron deposition on the fear circuit of the brain in patients with Parkinson’s disease and anxiety. Front Aging Neurosci 15:1116516. https://doi.org/10.3389/fnagi.2023.1116516
Article CAS PubMed PubMed Central Google Scholar
Cheng Q, Huang J, Liang J et al (2020) Evaluation of abnormal iron distribution in specific regions in the brains of patients with Parkinson’s disease using quantitative susceptibility mapping and R2* mapping. Exp Ther Med 19:3778–3786. https://doi.org/10.3892/etm.2020.8645
Article CAS PubMed PubMed Central Google Scholar
Cosottini M, Donatelli G, Ricca I et al (2022) Iron-sensitive MR imaging of the primary motor cortex to differentiate hereditary spastic paraplegia from other motor neuron diseases. Eur Radiol 32:8058–8064. https://doi.org/10.1007/s00330-022-08865-6
Article CAS PubMed Google Scholar
Costa-Mallen P, Zabetian CP, Agarwal P et al (2015) Haptoglobin phenotype modifies serum iron levels and the effect of smoking on Parkinson disease risk. Parkinsonism Relat Disord 21:1087–1092. https://doi.org/10.1016/j.parkreldis.2015.07.006
Article PubMed PubMed Central Google Scholar
Costa-Mallen P, Gatenby C, Friend S et al (2017) Brain iron concentrations in regions of interest and relation with serum iron levels in Parkinson disease. J Neurol Sci 378:38–44. https://doi.org/10.1016/j.jns.2017.04.035
Article CAS PubMed PubMed Central Google Scholar
Dashtipour K, Liu M, Kani C et al (2015) Iron accumulation is not homogenous among patients with Parkinson’s Disease. Parkinsons Dis 2015:324843. https://doi.org/10.1155/2015/324843
Article PubMed PubMed Central Google Scholar
Dekens DW, Eisel ULM, Gouweleeuw L et al (2021) Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases. Ageing Res Rev 70:101414. https://doi.org/10.1016/j.arr.2021.101414
Article CAS PubMed Google Scholar
Depierreux F, Parmentier E, Mackels L et al (2021) Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI. NPJ Parkinsons Dis 7:57. https://doi.org/10.1038/s41531-021-00199-2
Article CAS PubMed PubMed Central Google Scholar
Desai Bradaric B, Patel A, Schneider JA et al (2012) Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy. J Neural Transm (vienna) 119:59–71. https://doi.org/10.1007/s00702-011-0684-8
Devos D, Moreau C, Devedjian JC et al (2014) Targeting chelatable iron as a therapeutic modality in Parkinson’s disease. Antioxid Redox Signal 21:195–210. https://doi.org/10.1089/ars.2013.5593
Article CAS PubMed PubMed Central Google Scholar
Devos D, Labreuche J, Rascol O et al (2022) Trial of deferiprone in Parkinson’s disease. N Engl J Med 387:2045–2055. https://doi.org/10.1056/NEJMoa2209254
Article CAS PubMed Google Scholar
Dexter DT, Wells FR, Agid F et al (1987) Increased nigral iron content in postmortem parkinsonian brain. Lancet 2:1219–1220. https://doi.org/10.1016/s0140-6736(87)91361-4
Article CAS PubMed Google Scholar
Dexter DT, Carayon A, Javoy-Agid F et al (1991) Alterations in the levels of iron, ferritin and other trace metals in Parkinson’s disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114(Pt 4):1953–1975. https://doi.org/10.1093/brain/114.4.1953
Du G, Lewis MM, Sica C et al (2018) Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson’s patients. Mov Disord 33:1423–1431. https://doi.org/10.1002/mds.27318
Article PubMed PubMed Central Google Scholar
Du G, Wang E, Sica C et al (2022) Dynamics of nigral iron accumulation in Parkinson’s disease: from diagnosis to late stage. Mov Disord 37:1654–1662. https://doi.org/10.1002/mds.29062
Article CAS PubMed PubMed Central Google Scholar
Dusek P, Hofer T, Alexander J et al (2022) Cerebral Iron Deposition in Neurodegeneration. Biomolecules 12:714. https://doi.org/10.3390/biom12050714
Article CAS PubMed PubMed Central Google Scholar
Febbraro F, Giorgi M, Caldarola S et al (2012) α-Synuclein expression is modulated at the translational level by iron. NeuroReport 23:576–580. https://doi.org/10.1097/WNR.0b013e328354a1f0
Article CAS PubMed Google Scholar
Fischbacher A, von Sonntag C, Schmidt TC (2017) Hydroxyl radical yields in the Fenton process under various pH, ligand concentrations and hydrogen peroxide/Fe(II) ratios. Chemosphere 182:738–744. https://doi.org/10.1016/j.chemosphere.2017.05.039
Article ADS CAS PubMed Google Scholar
Foroutan P, Murray ME, Fujioka S et al (2013) Progressive supranuclear palsy: high-field-strength MR microscopy in the human substantia nigra and globus pallidus. Radiology 266:280–288. https://doi.org/10.1148/radiol.12102273
Article PubMed PubMed Central Google Scholar
Friedlich AL, Tanzi RE, Rogers JT (2007) The 5’-untranslated region of Parkinson’s disease alpha-synuclein messengerRNA contains a predicted iron responsive element. Mol Psychiatry 12:222–223. https://doi.org/10.1038/sj.mp.4001937
Article CAS PubMed Google Scholar
Friedman A, Galazka-Friedman J (2012) The history of the research of iron in Parkinsonian substantia nigra. J Neural Transm (vienna) 119:1507–1510. https://doi.org/10.1007/s00702-012-0894-8
Article CAS PubMed Google Scholar
Fu X, Deng W, Cui X et al (2021) Time-specific pattern of iron deposition in different regions in Parkinson’s disease measured by quantitative susceptibility mapping. Front Neurol 12:631210. https://doi.org/10.3389/fneur.2021.631210
Comments (0)