Chen-Che Hsieh, Institute of Biotechnology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, TaiwanFollow
Shu-Han Yu, Institute of Biotechnology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan
Hsing-Chun Kuo, Division of Basic Medical Sciences, Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan
Darin Khumsupan, Institute of Biotechnology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan
Hsiao-Chu Huang, Institute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan
Yu-Wei Liou, Institute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan
Chen-Yu Kao, Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
Szu-Chuan Shen, Undergraduate and Graduate Programs of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei, Taiwan
Kuan-Chen Cheng, Institute of Biotechnology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan

Rhizopus oligosporus was utilized in the solid-state fermentation of Chenopodium formosanum sprouts (FCS) in a bioreactor. Subsequently, the antioxidant activity of food proteins derived from FCS was investigated. Results showed that glycine-rich peptide (GGGGGKP, G-rich peptide), identified from the in silico and in vitro studies to evaluate its potential alleviating oxidative stress caused by particulate matter. This study proposed plausible mechanisms that involve the binding of G-rich peptide which inhibited phosphorylation of the v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) subunit on NF-κB pathway. The inhibition then resulted in down regulation of NF-κB transcription and genetic expression of inflammatory responses. These findings suggested that G-rich peptide from FCS proteins can potentially alleviate oxidative stress.

Hsieh, Chen-Che; Yu, Shu-Han; Kuo, Hsing-Chun; Khumsupan, Darin; Huang, Hsiao-Chu; Liou, Yu-Wei; Kao, Chen-Yu; Shen, Szu-Chuan; and Cheng, Kuan-Chen (2023) "Glycine-rich peptides from fermented Chenopodium formosanum sprout as an antioxidant to modulate the oxidative stress," Journal of Food and Drug Analysis: Vol. 31 : Iss. 4 , Article 5.
Available at: https://doi.org/10.38212/2224-6614.3476

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