Dehelean CA, Marcovici I, Soica C, Mioc M, Coricovac D, Iurciuc S, et al. Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy. Molecules. 2021;26(4):1109. https://doi.org/10.3390/molecules26041109.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang M, Lu JJ, Ding J. Natural products in cancer therapy: past, present and future. Nat Prod Bioprospect. 2021;11(1):5–13. https://doi.org/10.1007/s13659-020-00293-7.

Article  PubMed  PubMed Central  Google Scholar 

Milutinović MG, Maksimović VM, Cvetković DC, Nikodijević DD, Stanković MS, Pešić MS, et al. Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells. J Ethnopharmacol. 2019;240: 111951. https://doi.org/10.1016/j.jep.2019.111951.

Article  PubMed  Google Scholar 

Nikodijević DD, Milutinović MG, Cvetković DM, Ćupurdija MĐ, Jovanović MM, Mrkić IV, et al. Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines. Toxin Rev. 2019;40(4):1272–9. https://doi.org/10.1080/15569543.2019.1680564.

Article  CAS  Google Scholar 

Sajjadn H, Imtiaz S, Noor T, Siddiqui YH, Sajjad A, Zia M. Cancer models in preclinical research: a chronicle review of advancement in effective cancer research. Animal Model Exp Med. 2021;4(2): 87–103. https://doi.org/10.1002/ame2.12165 [Accessed 12 May 2023].

Article  Google Scholar 

Jovankić JV, Nikodijević DD, Milutinović MG, Nikezić AG, Kojić VV, Cvetković A, et al. Potential of Orlistat to induce apoptotic and antiangiogenic effects as well as inhibition of fatty acid synthesis in breast cancer cells. Eur J Pharmacol. 2023;939:54666.

Article  Google Scholar 

Abbott A. Cell culture: biology’s new dimension. Nature. 2003;424(6951):870–2. https://doi.org/10.1038/424870a.

Article  CAS  PubMed  Google Scholar 

Martinez MM, Reif RD, Pappas D. Detection of apoptosis: a review of conventional and novel techniques. Anal Methods. 2010;2(8):996–1004. https://doi.org/10.1039/C0AY00247J.

Article  CAS  Google Scholar 

Guo M, Lu B, Gan J, Wang S, Jiang X, Li H. Apoptosis detection: a purpose-dependent approach selection. Cell Cycle. 2021;20(11):1033–40. https://doi.org/10.1080/15384101.2021.1919830.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Engeland M, Nieland LJW, Ramaekers FCS, Schutte B, Reutelingsperger CPM. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytom A. 1998;31(1):1–9.

Article  Google Scholar 

Mirsaeidi M, Gidfar S, Vu A, Schraufnagel D. Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis. J Transl Med. 2016;14:1–9. https://doi.org/10.1186/s12967-016-0843-7.

Article  CAS  Google Scholar 

McKinnon KM. Flow cytometry: an overview. Curr Protoc Immunol. 2018;120:5.1.1-5.1.11. https://doi.org/10.1002/cpim.40.

Article  PubMed  Google Scholar 

Jurisic V, Srdic-Rajic T, Konjevic G, Bogdanovic G, Colic M. TNF-α induced apoptosis is accompanied with rapid CD30 and slower CD45 shedding from K-562 cells. J Membr Biol. 2011;239(3):115–22. https://doi.org/10.1007/s00232-010-9309-7.

Article  CAS  PubMed  Google Scholar 

Crowley LC, Marfell BJ, Scott AP, Waterhouse NJ. Quantitation of apoptosis and necrosis by annexin V binding, propidium iodide uptake, and flow cytometry. Cold Spring Harb Protoc. 2016. https://doi.org/10.1101/pdb.prot087288.

Article  PubMed  Google Scholar 

Milutinović M, Stanković M, Cvetković D, Maksimović V, Šmit B, Pavlović R, et al. The molecular mechanisms of apoptosis induced by Allium favum L. and synergistic effects with new-synthesized Pd(II) complex on colon cancer cells. J Food Biochem. 2015;39(3):238–50. https://doi.org/10.1111/jfbc.12123.

Article  CAS  Google Scholar 

Shounan Y, Feng X, O’Connell PJ. Apoptosis detection by annexin V binding: a novel method for the quantitation of cell-mediated cytotoxicity. J Immunol Methods. 1998;217(1–2):61–70. https://doi.org/10.1016/s0022-1759(98)00090-8.

Article  CAS  PubMed  Google Scholar 

Lyon PC, Suomi V, Jakeman P, Campo L, Coussios C, Carlisle R. Quantifying cell death induced by doxorubicin, hyperthermia or HIFU ablation with flow cytometry. Sci Rep. 2021;11(1):4404. https://doi.org/10.1038/s41598-021-83845-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaur M, Esau L. Two-step protocol for preparing adherent cells for high-throughput flow cytometry. Biotechniques. 2015;59(3):119–26. https://doi.org/10.2144/000114325.

Article  CAS  PubMed  Google Scholar 

Falzone N, Huyser C, Franken DR. Comparison between propidium iodide and 7-amino-actinomycin-D for viability assessment during flow cytometric analyses of the human sperm acrosome. Andrologia. 2010;42(1):20–6. https://doi.org/10.1111/j.1439-0272.2009.00949.x.

Article  CAS  PubMed  Google Scholar 

Jurisic V, Bogdanovic G, Kojic V, Jakimov D, Srdic T. Effect of TNF-alpha on Raji cells at different cellular levels estimated by various methods. Ann Hematol. 2006;85(2):86–94. https://doi.org/10.1007/s00277-005-0010-3.

Article  CAS  PubMed  Google Scholar 

Savitskaya MA, Onishchenko GE. Mechanisms of apoptosis. Biochem (Mosc). 2015;80(11):1393–405. https://doi.org/10.1134/S0006297915110012.

Article  CAS  Google Scholar 

Nikodijević D, Jovankić J, Cvetković D, Anđelković M, Nikezić A, Milutinović M. L-amino acid oxidase from snake venom: biotransformation and induction of apoptosis in human colon cancer cells. Eur J Pharmacol. 2021;910: 174466. https://doi.org/10.1016/j.ejphar.2021.174466.

Article  CAS  PubMed  Google Scholar