Melatonin alleviates necrotizing enterocolitis by reducing bile acid levels through the SIRT1/FXR signalling axis
Keywords
Melatonin
Necrotizing enterocolitis
Bile acids
AbbreviationsASBT
apical membrane sodium-dependent bile acid transporters
CDCA
chenodeoxycholic acid
DEGs
differentially expressed genes
GCDCA
glycochenodeoxycholic acid
GDCA
glycodeoxycholic acid
GLCA
glycolithocholic acid
GUDCA
glycoursodeoxycholic acid
HNF-1α
hepatocyte nuclear factor-1 alpha
IBABP
ileal bile acid-binding protein
KEGG
kyoto Encyclopedia of Genes and Genomes
LC–MS/MS
liquid chromatography-tandem mass spectrometry
NEC
necrotizing enterocolitis
OST-α
organic solute transporter-alpha
OSTαβ
heteromeric organic solute transporter
OST-β
organic solute transporter beta
SHP
small heterodimer partner
TCDCA
taurochenodeoxycholic acid
TLCA
taurolithocholic acid
TUDCA
tauroursodeoxycholic acid
UPLC
ultrahigh-performance liquid chromatography
Data availability
Data will be made available on request.
© 2023 The Author(s). Published by Elsevier B.V.
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