Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA: A Cancer Journal for clinicians. 73:17–48
Giaquinto AN, Sung H, Miller KD, Kramer JL, Newman LA, Minihan A, Jemal A, Siegel RL (2022) Breast cancer statistics, 2022. CA A Cancer J Clin 72:524–541
Lourenço C, Conceição F, Jerónimo C, Lamghari M, Sousa DM (2022) Stress in metastatic breast cancer: to the bone and beyond. Cancers 14:1881
Article PubMed PubMed Central Google Scholar
Huber-Keener KJ (2022) Cancer genetics and breast cancer. Best Practice Res Clin Obst Gynaecol. https://doi.org/10.1016/j.bpobgyn.2022.01.007
(2023/17/5) World Health Organization (WHO). Obesity and overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
Ward ZJ, Bleich SN, Cradock AL, Barrett JL, Giles CM, Flax C, Long MW, Gortmaker SL (2019) Projected US state-level prevalence of adult obesity and severe obesity. N Engl J Med 381:2440–2450
(2023/17/5) World Health Organization (WHO). Diabetes. https://www.who.int/news-room/fact-sheets/detail/diabetes.
Bhardwaj P, Iyengar NM, Zahid H, Carter KM, Byun DJ, Choi MH, Sun Q, Savenkov O, Louka C, Liu C (2023) Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2. Sci Transl Med 15:1857
Hassanein MT, Lyon HN, Nguyen TT, Akylbekova EL, Waters K, Lettre G, Tayo B, Forrester T, Sarpong DF, Stram DO (2010) Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet 19:2907–2916
Article CAS PubMed PubMed Central Google Scholar
Huang J, Huffman JE, Huang Y, Do Valle Í, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási A-L, Huang RD (2022) Genomics and phenomics of body mass index reveals a complex disease network. Nat Commun 13:7973
Article CAS PubMed PubMed Central Google Scholar
Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N (2021) Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab 3:228–243
Article CAS PubMed Google Scholar
Lee SC, Chan JC (2015) Evidence for DNA damage as a biological link between diabetes and cancer. Chin Med J 128:1543–1548
Article CAS PubMed PubMed Central Google Scholar
Usman M, Volpi EV (2018) DNA damage in obesity: initiator, promoter and predictor of cancer. Mutation Res/Rev Mutation Res 778:23–37
Włodarczyk M, Nowicka G (2019) Obesity, DNA damage, and development of obesity-related diseases. Int J Mol Sci 20:1146
Article PubMed PubMed Central Google Scholar
Brown KA (2021) Metabolic pathways in obesity-related breast cancer. Nat Rev Endocrinol 17:350–363
Article PubMed PubMed Central Google Scholar
Kang C, LeRoith D, Gallagher EJ (2018) Diabetes, obesity, and breast cancer. Endocrinology 159:3801–3812
Article CAS PubMed PubMed Central Google Scholar
Parada H Jr, Cleveland RJ, North KE, Stevens J, Teitelbaum SL, Neugut AI, Santella RM, Martinez ME, Gammon MD (2019) Genetic polymorphisms of diabetes-related genes, their interaction with diabetes status, and breast cancer incidence and mortality: the Long Island Breast Cancer Study Project. Mol Carcinog 58:436–446
Article CAS PubMed Google Scholar
Rahman I, Athar MT, Islam M (2021) Type 2 diabetes, obesity, and cancer share some common and critical pathways. Front Oncol 10:600824
Article PubMed PubMed Central Google Scholar
Zimta A-A, Tigu AB, Muntean M, Cenariu D, Slaby O, Berindan-Neagoe I (2019) Molecular links between central obesity and breast cancer. Int J Mol Sci 20:5364
Article CAS PubMed PubMed Central Google Scholar
Sollis E, Mosaku A, Abid A, Buniello A, Cerezo M, Gil L, Groza T, Güneş O, Hall P, Hayhurst J (2023) The NHGRI-EBI GWAS catalog: knowledgebase and deposition resource. Nucleic Acids Res 51:D977–D985
Article CAS PubMed Google Scholar
Ward LD, Kellis M (2012) HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 40:D930–D934
Article CAS PubMed Google Scholar
Sherry ST, Ward M, Sirotkin K (1999) dbSNP—database for single nucleotide polymorphisms and other classes of minor genetic variation. Genome Res 9:677–679
Article CAS PubMed Google Scholar
Cunningham F, Allen JE, Allen J, Alvarez-Jarreta J, Amode MR, Armean IM, Austine-Orimoloye O, Azov AG, Barnes I, Bennett R (2022) Ensembl 2022. Nucleic Acids Res 50:D988–D995
Article CAS PubMed Google Scholar
Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, Karczewski KJ, Park J, Hitz BC, Weng S (2012) Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 22:1790–1797
Article CAS PubMed PubMed Central Google Scholar
Yang Y, Wang D, Miao Y-R, Wu X, Luo H, Cao W, Yang W, Yang J, Guo A-Y, Gong J (2023) lncRNASNP v3: an updated database for functional variants in long non-coding RNAs. Nucleic Acids Res 51:D192–D198
Article CAS PubMed Google Scholar
Agarwal V, Bell GW, Nam J-W, Bartel DP (2015) Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:e05005
Article PubMed PubMed Central Google Scholar
Piñero J, Bravo À, Queralt-Rosinach N, Gutiérrez-Sacristán A, Deu-Pons J, Centeno E, García-García J, Sanz F, Furlong LI (2016) DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. Nucleic acids research:gkw943.
Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y (2016) The GeneCards suite: from gene data mining to disease genome sequence analyses. Current Protocols Bioinfo 54:1
Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP (2015) STRING v10: protein–protein interaction networks, integrated over the tree of life. Nucleic Acids Res 43:D447–D452
Article CAS PubMed Google Scholar
Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B, Liu XS (2020) TIMER2. 0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res 48:W509–W514
Article CAS PubMed PubMed Central Google Scholar
Tang G, Cho M, Wang X (2022) OncoDB: an interactive online database for analysis of gene expression and viral infection in cancer. Nucleic Acids Res 50:D1334–D1339
Article CAS PubMed Google Scholar
Pletscher-Frankild S, Pallejà A, Tsafou K, Binder JX, Jensen LJ (2015) DISEASES: Text mining and data integration of disease–gene associations. Methods 74:83–89
Article CAS PubMed Google Scholar
Mahajan A, Spracklen CN, Zhang W, Ng MC, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ (2022) Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet 54:560–572
Article CAS PubMed PubMed Central Google Scholar
Zhou K, Yee SW, Seiser EL, Van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, Van Der Heijden AA, Beulens JW (2016) Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet 48:1055–1059
Article CAS PubMed PubMed Central Google Scholar
Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K (2017) Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nat Genet 49:1458–1467
Article CAS PubMed Google Scholar
Lushchyk M, Ameliyanovich M, Tuzava H, Mosse I, Danilova LI (2021) Selection of the most effective genetic tests for the diabetes mellitus risk prediction in Belarus. Endocrine Abstracts. https://doi.org/10.1530/endoabs.73.PEP15.4
Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum PY, Suver C, Chudin E, Kemp D, Reitman M (2009) Common body mass index-associated variants confer risk of extreme obesity. Hum Mol Genet 18:3502–3507
Article CAS PubMed PubMed Central Google Scholar
Gholamalizadeh M, Jarrahi AM, Akbari ME, Bourbour F, Mokhtari Z, Salahshoornezhad S, Doaei S (2020) Association between FTO gene polymorphisms and breast cancer: the role of estrogen. Expert Rev Endocrinol Metab 15:115–121
Article CAS PubMed Google Scholar
Pettersen E, Skorpen F, Kvaløy K, Midthjell K, Grill V (2010) Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag health study. Diabetes 59:302–310
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