Chow LQM (2020) Head and neck cancer. N Engl J Med 382:60–72. https://doi.org/10.1056/NEJMra1715715

Article  CAS  PubMed  Google Scholar 

Iacovelli NA, Galaverni M, Cavallo A, Naimo S, Facchinetti N, Iotti C et al (2018) Prevention and treatment of radiation-induced acute dermatitis in head and neck cancer patients: a systematic review. Future Oncol 14:291–305. https://doi.org/10.2217/fon-2017-0359

Article  CAS  PubMed  Google Scholar 

Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB et al (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 354(6):567–78. https://doi.org/10.1056/NEJMoa053422

Article  CAS  PubMed  Google Scholar 

Ferreira BC, Sá-Couto P, Lopes MC, Khouri L (2016) Compliance to radiation therapy of head and neck cancer patients and impact on treatment outcome. Clin Transl Oncol 18:677–684. https://doi.org/10.1007/s12094-015-1417-5

Article  CAS  PubMed  Google Scholar 

Fesinmeyer MD, Mehta V, Blough D, Tock L, Ramsey SD (2010) Effect of radiotherapy interruptions on survival in Medicare enrollees with local and regional head-and-neck cancer. Int J Radiat Oncol Biol Phys 78:675–81. https://doi.org/10.1016/j.ijrobp.2009.08.004

Article  PubMed  Google Scholar 

Wong RKS, Bensadoun R-J, Boers-Doets CB, Bryce J, Chan A, Epstein JB et al (2013) Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group. Support Care Cancer 21:2933–2948. https://doi.org/10.1007/s00520-013-1896-2

Article  PubMed  Google Scholar 

Behroozian T, Goldshtein D, Ryan Wolf J, van den Hurk C, Finkelstein S, Lam H et al (2023) MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review. EClinicalMedicine 58:101886. https://doi.org/10.1016/j.eclinm.2023.101886

Article  PubMed  PubMed Central  Google Scholar 

Zhang Q, Wang Y, Yang S, Wu Q, Qiang W (2022) What is the appropriate skin cleaning method for nasopharyngeal cancer radiotherapy patients? A randomized controlled trial. Support Care Cancer. https://doi.org/10.1007/s00520-022-06835-8

Article  PubMed  PubMed Central  Google Scholar 

Lee C-J, Fang H-F, Wang C-Y, Chou K-R, Huang T-W (2022) Effect of hyaluronic acid on radiodermatitis in patients with breast cancer: a meta-analysis of randomized controlled trials. Support Care Cancer 30:3965–3975. https://doi.org/10.1007/s00520-022-06828-7

Article  PubMed  Google Scholar 

Fatima S, Hirakawa S, Marta GN, Caini S, Beveridge M, Bonomo P et al (2023) Topical non-steroidal agents for the prevention of radiation dermatitis: a systematic review and meta-analysis. Support Care Cancer 31:217. https://doi.org/10.1007/s00520-023-07677-8

Article  PubMed  Google Scholar 

Robijns J, Lodewijckx J, Claes S, Van Bever L, Pannekoeke L, Censabella S et al (2021) Photobiomodulation therapy for the prevention of acute radiation dermatitis in head and neck cancer patients (DERMISHEAD trial). Radiother Oncol 158:268–275. https://doi.org/10.1016/j.radonc.2021.03.002

Article  PubMed  Google Scholar 

Sunku R, Kalita AK, Bhattacharyya M, Medhi PP, Bansal S, Borah L et al (2021) Effect of corticosteroid ointment on radiation induced dermatitis in head and neck cancer patients: a prospective study. Indian J Cancer 58:69–75. https://doi.org/10.4103/ijc.IJC_790_18

Article  PubMed  Google Scholar 

Yokota T, Zenda S, Ota I, Yamazaki T, Yamaguchi T, Ogawa T et al (2021) Phase 3 randomized trial of topical steroid versus placebo for prevention of radiation dermatitis in patients with head and neck cancer receiving chemoradiation. Int J Radiat Oncol Biol Phys 111:794–803. https://doi.org/10.1016/j.ijrobp.2021.05.133

Article  PubMed  Google Scholar 

Behroozian T, Bonomo P, Patel P, Kanee L, Finkelstein S, van den Hurk C et al (2023) Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidelines for the prevention and management of acute radiation dermatitis: international Delphi consensus-based recommendations. Lancet Oncol 24:e172–e185. https://doi.org/10.1016/S1470-2045(23)00067-0

Article  PubMed  Google Scholar 

Gollins S, Gaffney C, Slade S, Swindell R (2008) RCT on gentian violet versus a hydrogel dressing for radiotherapy-induced moist skin desquamation. J Wound Care 17:268–75. https://doi.org/10.12968/jowc.2008.17.6.29589

Article  CAS  PubMed  Google Scholar 

Bailly C, Giraud P, Lahalle C (2008) Utilisation d’un pansement hydrogel (Hydrosorb) dans la prévention et le traitement des radiodermites. JPC 13:89–92

Google Scholar 

Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376. https://doi.org/10.1093/jnci/85.5.365

Article  CAS  PubMed  Google Scholar 

Iacovelli NA, Torrente Y, Ciuffreda A, Guardamagna VA, Gentili M, Giacomelli L et al (2020) Topical treatment of radiation-induced dermatitis: current issues and potential solutions. DIC 9:1–13. https://doi.org/10.7573/dic.2020-4-7

Article  Google Scholar 

Macmillan MS, Wells M, MacBride S, Raab GM, Munro A, MacDougall H (2007) Randomized comparison of dry dressings versus hydrogel in management of radiation-induced moist desquamation. Int J Radiat Oncol Biol Phys 68:864–72. https://doi.org/10.1016/j.ijrobp.2006.12.049

Article  CAS  PubMed  Google Scholar 

Liguori V, Guillemin C, Pesce GF, Mirimanoff RO, Bernier J (1997) Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother Oncol 42:155–161. https://doi.org/10.1016/S0167-8140(96)01882-8

Article  CAS  PubMed  Google Scholar 

Liao Y, Feng G, Dai T, Long F, Tang J, Pu Y et al (2019) Randomized, self-controlled, prospective assessment of the efficacy of mometasone furoate local application in reducing acute radiation dermatitis in patients with head and neck squamous cell carcinomas. Medicine 98:e18230. https://doi.org/10.1097/MD.0000000000018230

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan J, Yuan L, Wang J, Li S, Yao M, Wang K et al (2020) Mepitel film is superior to Biafine cream in managing acute radiation-induced skin reactions in head and neck cancer patients: a randomised intra-patient controlled clinical trial. J Med Radiat Sci 67:208–216. https://doi.org/10.1002/jmrs.397

Article  PubMed  PubMed Central  Google Scholar 

Rolnick SJ, Pawloski PA, Hedblom BD, Asche SE, Bruzek RJ (2013) Patient characteristics associated with medication adherence. Clin Med Res 11:54–65. https://doi.org/10.3121/cmr.2013.1113

Article  PubMed  PubMed Central  Google Scholar 

DiMatteo MR (2004) Variations in patients’ adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 42:200–9

Article  PubMed  Google Scholar 

Rades D, Narvaez CA, Doemer C, Janssen S, Olbrich D, Tvilsted S et al (2020) Radiotherapy-related skin toxicity (RAREST-02): a randomized trial testing the effect of a mobile application reminding head-and-neck cancer patients to perform skin care (reminder app) on radiation dermatitis. Trials 21:424. https://doi.org/10.1186/s13063-020-04307-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tomic-Canic M, Wong LL, Smola H (2018) The epithelialisation phase in wound healing: options to enhance wound closure. J Wound Care 27:646–58. https://doi.org/10.12968/jowc.2018.27.10.646

Article  PubMed  Google Scholar 

Carter K (2003) Hydropolymer dressings in the management of wound exudate. Br J Community Nurs 8:10–6. https://doi.org/10.12968/bjcn.2003.8.Sup3.11579

Article  Google Scholar 

Périé S, Meyers M, Mazzaschi O, de Crouy Chanel O, Baujat B, St Guily JL (2014) Épidémiologie et anatomie des cancers ORL. Bulletin du Cancer 101:404–10. https://doi.org/10.1684/bdc.2014.1962

Article  PubMed  Google Scholar