American Cancer Society (2021) Cancer Facts & Figures. https://www.cancer.org/cancer/cancer-in-children/key-statistics.html#references. Accessed Apr 2021

Krull KR et al (2013) Neurocognitive outcomes decades after treatment for childhood acute lymphoblastic leukemia: a report from the St Jude lifetime cohort study. J of Clin Oncol 31:4407. https://doi.org/10.1200/JCO.2012.48.2315

Article  Google Scholar 

Lofstad GE et al (2019) Neurocognitive outcomes and compensating possibilities in children and adolescents treated for acute lymphoblastic leukemia with chemotherapy only. Front Psychol 10:1027. https://doi.org/10.3389/fpsyg.2019.01027

Article  PubMed  PubMed Central  Google Scholar 

Pui C-H, Evans WE (2013) A 50-year journey to cure childhood acute lymphoblastic leukemia. Semin Hematol 50:185–196. https://doi.org/10.1053/j.seminhematol.2013.06.007

Article  PubMed  PubMed Central  Google Scholar 

Conklin HM et al (2012) Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia. J Natl Cancer Inst 104:1386–1395. https://doi.org/10.1093/jnci/djs344

Article  PubMed  PubMed Central  CAS  Google Scholar 

van der Plas E et al (2021) Cognitive impairment in survivors of pediatric acute lymphoblastic leukemia treated with chemotherapy only. J Clin Oncol 39(16):1705–17. https://doi.org/10.1200/jco.20.02322

Article  PubMed  Google Scholar 

Hardy KK et al (2017) Neurocognitive functioning of children treated for high-risk B-acute lymphoblastic leukemia randomly assigned to different methotrexate and corticosteroid treatment strategies: a report from the children’s oncology group. J Clin Oncol 35:2700–7. https://doi.org/10.1200/jco.2016.71.7587

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu W et al (2018) Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. J Cancer Surviv 12(3):398–406. https://doi.org/10.1007/s11764-018-0679-7

Article  PubMed  PubMed Central  Google Scholar 

Jacola LM et al (2016) Longitudinal assessment of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy protocol. J of Clin Oncol 34:1239–1247. https://doi.org/10.1200/jco.2015.64.3205

Article  CAS  Google Scholar 

Sherief LM et al (2018) A cross-sectional study of two chemotherapy protocols on long term neurocognitive functions in Egyptian children surviving acute lymphoblastic leukemia. Curr Pediatr Rev 14(4):253–260. https://doi.org/10.2174/1573396314666181031134919

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sleurs C et al (2017) Intellectual development of childhood ALL patients: a multicenter longitudinal study. Psychooncology 26(4):508–514. https://doi.org/10.1002/pon.4186

Article  PubMed  Google Scholar 

Cheung YT et al (2017) Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia. Cancer 123:3410–3419. https://doi.org/10.1002/cncr.30742

Article  PubMed  CAS  Google Scholar 

von der Weid N et al (2003) Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: age-and sex-related differences. Eur J Cancer 39:359–365. https://doi.org/10.1016/s0959-8049(02)00260-5

Article  PubMed  Google Scholar 

Jacola LM et al (2021) Adaptive functioning and academic achievement in survivors of childhood acute lymphoblastic leukemia: A report from the Children’s Oncology Group. Pediatr Blood Cancer 68(4):e28913. https://doi.org/10.1002/pbc.28913

Article  PubMed  PubMed Central  Google Scholar 

Jacola LM et al (2016) Cognitive, behaviour, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study. Lancet Psychiatry 3(10):965–972. https://doi.org/10.1016/S2215-0366(16)30283-8

Article  PubMed  PubMed Central  Google Scholar 

Kunin-Batson A, Kadan-Lottick N, Neglia JP (2014) The contribution of neurocognitive functioning to quality of life after childhood acute lymphoblastic leukemia. Psychooncol 23(6):692–699. https://doi.org/10.1002/pon.3470

Article  Google Scholar 

Bhojwani D et al (2014) Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia. J Clin Oncol 32(9):949–959. https://doi.org/10.1200/jco.2013.53.0808

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rijmenams I et al (2021) Age- and intravenous methotrexate-associated leukoencephalopathy and its neurological impact in pediatric patients with lymphoblastic leukemia. Cancers (Basel) 13(8):1939. https://doi.org/10.3390/cancers13081939

Article  PubMed  CAS  Google Scholar 

Guo J, Han Y, Li Y, Reddick WE (2019) Reduced brain microstructural asymmetry in patients with childhood leukemia treated with chemotherapy compared with healthy controls. PLoS ONE 14:e0216554. https://doi.org/10.1371/journal.pone.0216554

Article  PubMed  PubMed Central  Google Scholar 

Kesler SR et al (2018) Brain network connectivity and executive function in long-term survivors of childhood acute lymphoblastic leukemia. Brain Connect 8(6):333–342. https://doi.org/10.1089/brain.2017.0574

Article  PubMed  PubMed Central  Google Scholar 

Kesler SR, Gugel M, Huston-Warren E, Watson C (2016) Atypical structural connectome organization and cognitive impairment in young survivors of acute lymphoblastic leukemia. Brain Connect 6(4):273–282. https://doi.org/10.1089/brain.2015.0409

Article  PubMed  PubMed Central  Google Scholar 

Zou L et al (2017) Abnormal topological organization in white matter structural networks in survivors of acute lymphoblastic leukaemia with chemotherapy treatment. Oncotarget 8:60568–60575. https://doi.org/10.18632/oncotarget.19104

Article  PubMed  PubMed Central  Google Scholar 

Harman JL et al (2019) Parent-reported executive functioning in young children treated for cancer. Child Neuropsychol 25(4):548–560. https://doi.org/10.1080/09297049.2018.1503647

Article  PubMed  Google Scholar 

Kenney AE, Harman JL, Molnar AE et al (2020) Early cognitive and adaptive functioning of clinically referred infants and toddlers with cancer. J Clin Psychol Med Settings 27:41–47. https://doi.org/10.1007/s10880-019-09619-1

Article  PubMed  Google Scholar 

Willard VW et al (2017) Cognitive and psychosocial functioning of preschool-aged children with cancer. J Dev Behav Pediatr 38(8):638–645. https://doi.org/10.1097/DBP.0000000000000512

Article  PubMed  Google Scholar 

Coombs A, Schilperoort H, Sargent B (2020) The effect of exercise and motor interventions on physical activity and motor outcomes during and after medical intervention for children and adolescents with acute lymphoblastic leukemia: A systematic review. Crit Rev Oncol Hematol 152:103004. https://doi.org/10.1016/j.critrevonc.2020.103004

Article  PubMed  PubMed Central  Google Scholar 

Tanner L, Sencer S, Hooke MC (2017) The stoplight program: a proactive physical therapy intervention for children with acute lymphoblastic leukemia. J Pediatr Oncol Nurs 34(5):347–357. https://doi.org/10.1177/1043454217698093

Article  PubMed  Google Scholar 

Yildiz Kabak V, Ekinci Y, Atasavun Uysal S, Cetin M, Duger T (2021) Motor and basic cognitive functions in children with acute lymphoblastic leukemia undergoing induction or consolidation chemotherapy. Percept Mot Skills 128(3):1091–1106. https://doi.org/10.1177/00315125211002065

Article  PubMed  Google Scholar 

Hanna S, Elshennawy S, El-Ayadi M, Abdelazeim F (2020) Investigating fine motor deficits during maintenance therapy in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 67(7):e28385. https://doi.org/10.1002/pbc.28385

Article  PubMed  CAS  Google Scholar 

Marchese V, Rock K, York T, Creath R, Gray V (2021) Neuromuscular mechanisms that contribute to gross motor performance in survivors of childhood acute lymphoblastic leukemia. J Pediatr Rehabil Med 14(3):415–423. https://doi.org/10.3233/PRM-200784

Article  PubMed  PubMed Central  Google Scholar 

Jeha S et al (2019) Improved CNS control of childhood acute lymphoblastic leukemia without cranial irradiation: St Jude Total Therapy Study 16. J Clin Oncol 37(35):3377–3391. https://doi.org/10.1200/jco.19.01692

Article  PubMed  PubMed Central  CAS  Google Scholar 

Buck GM, Msall ME, Schisterman EF, Lyon NR, Rogers BT (2000) Extreme prematurity and school outcomes. Paediatr Perinat Epidemiol 14(4):324–331. https://doi.org/10.1046/j.1365-3016.2000.00276.x

Article  PubMed  CAS  Google Scholar 

Marcin JP, Schembri MS, He J, Romano PS (2003) A population-based analysis of socioeconomic status and insurance status and their relationship with pediatric trauma hospitalization and mortality rates. Am J Public Health 93:461–466. https://doi.org/10.2105/ajph.93.3.461

Article  PubMed  PubMed Central  Google Scholar 

Roid GH (2003) Stanford-Binet Intelligence Scales-Fifth Edition. Riverside Publishing, Itasca, IL

Google Scholar 

Conners CK (2006) Conners’ kiddie continuous performance test. Multi-Health Systems Incorporated

Google Scholar 

Conners CK, Staff MHS (2004) Conners’ Continuous Performance Test (CPT II): Version 5 for Windows technical guide and software manual. Multi-Health Systems Incorporated