Mark DB, Anstrom KJ, Sheng S, Piccini JP, Baloch KN, Monahan KH, et al. Effect of catheter ablation vs medical therapy on quality of life among patients with atrial fibrillation: the CABANA randomized clinical trial. JAMA. 2019;321(13):1275–85.

Article  PubMed  PubMed Central  Google Scholar 

Ouyang F, Tilz R, Chun J, Schmidt B, Wissner E, Zerm T, et al. Long-term results of catheter ablation in paroxysmal atrial fibrillation: lessons from a 5-year follow-up. Circulation. 2010;122(23):2368–77.

Article  PubMed  Google Scholar 

Scherr D, Khairy P, Miyazaki S, Aurillac-Lavignolle V, Pascale P, Wilton SB, et al. Five-year outcome of catheter ablation of persistent atrial fibrillation using termination of atrial fibrillation as a procedural endpoint. Circ Arrhythm Electrophysiol. 2015;8(1):18–24.

Article  CAS  PubMed  Google Scholar 

Hwang SH, Oh Y-W, Lee DI, Shim J, Park S-W, Kim Y-H. Evaluation of quantification methods for left arial late gadolinium enhancement based on different references in patients with atrial fibrillation. Int J Cardiovasc Imaging. 2015;Suppl 1:91–101.

Verma A, Wazni OM, Marrouche NF, Martin DO, Kilicaslan F, Minor S, et al. Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: an independent predictor of procedural failure. J Am Coll Cardiol. 2005;45(2):285–92.

Article  PubMed  Google Scholar 

Kircher S, Arya A, Altmann D, Rolf S, Bollmann A, Sommer P, et al. Individually tailored vs. standardized substrate modification during radiofrequency catheter ablation for atrial fibrillation: a randomized study. Europace. 2018;20(11):1766–1775.

Rolf S, Kircher S, Arya A, Eitel C, Sommer P, Richter S, et al. Tailored atrial substrate modification based on low-voltage areas in catheter ablation of atrial fibrillation. Circ Arrhythm Electrophysiol. 2014;7(5):825–33.

Article  PubMed  Google Scholar 

Kornej J, Schumacher K, Dinov B, Kosich F, Sommer P, Arya A, et al. Prediction of electro-anatomical substrate and arrhythmia recurrences using APPLE, DR-FLASH and MB-LATER scores in patients with atrial fibrillation undergoing catheter ablation. Sci Rep. 2018;8(1):12686.

Article  PubMed  PubMed Central  Google Scholar 

Kosiuk J, Dinov B, Kornej J, Acou W-J, Schönbauer R, Fiedler L, et al. Prospective, multicenter validation of a clinical risk score for left atrial arrhythmogenic substrate based on voltage analysis: DR-FLASH score. Heart Rhythm. 2015;12(11):2207–12.

Article  PubMed  Google Scholar 

Müller-Edenborn B, Chen J, Allgeier J, Didenko M, Moreno-Weidmann Z, Neumann F-J, et al. Amplified sinus-P-wave reveals localization and extent of left atrial low-voltage substrate: implications for arrhythmia freedom following pulmonary vein isolation. Europace. 2020;22(2):240–249.

Park J-K, Park J, Uhm J-S, Joung B, Lee M-H, Pak H-N. Low P-wave amplitude (<0.1 mV) in lead I is associated with displaced inter-atrial conduction and clinical recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation. Europace: European pacing, arrhythmias, and cardiac electrophysiology: Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2016;18(3):384–391.

Zhang ZR, Ragot D, Massin SZ, Suszko A, Ha ACT, Singh SM, et al. P-wave duration/amplitude ratio quantifies atrial low-voltage area and predicts atrial arrhythmia recurrence after pulmonary vein isolation. Can J Cardiol. 2023;39(10):1421–1431.

Kamel H, Bartz TM, Elkind MSV, Okin PM, Thacker EL, Patton KK, et al. Atrial cardiopathy and the risk of ischemic stroke in the CHS (cardiovascular health study). Stroke. 2018;49(4):980–6.

Article  PubMed  PubMed Central  Google Scholar 

German DM, Kabir MM, Dewland TA, Henrikson CA, Tereshchenko LG. Atrial fibrillation predictors: importance of the electrocardiogram. Ann Noninvasive Electrocardiol. 2016;21(1):20–9.

Sudo Y, Morimoto T, Tsushima R, Sogo M, Ozaki M, Takahashi M, et al. P-wave terminal force in lead V1 and outcomes in patients with persistent atrial fibrillation undergoing catheter ablation. Am Heart J. 2023;260:141–50.

Article  PubMed  Google Scholar 

Wolder LD, Graff C, Baadsgaard KH, Langgaard ML, Polcwiartek C, Ji-Young Lee C, et al. Electrocardiographic P terminal force in lead V1, its components, and the association with stroke and atrial fibrillation or flutter. Heart Rhythm. 2023;20(3):354–62.

Article  PubMed  Google Scholar 

Yang B, Jiang C, Lin Y, Yang G, Chu H, Cai H, et al. STABLE-SR (Electrophysiological substrate ablation in the left atrium during sinus rhythm) for the treatment of nonparoxysmal atrial fibrillation: a prospective, multicenter randomized clinical trial. Circ Arrhythm Electrophysiol. 2017;10(11):e005405.

Lin Y, Yang B, Garcia FC, Ju W, Zhang F, Chen H, et al. Comparison of left atrial electrophysiologic abnormalities during sinus rhythm in patients with different type of atrial fibrillation. J Interv Card Electrophysiol: Int J Arrhythm Pacing. 2014;39(1):57–67.

Article  Google Scholar 

Kwon Y, Misialek JR, Duprez D, Alonso A, Jacobs DR, Heckbert SR, et al. Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: the MESA study. Europace. 2017;19(11):1759–1766.

Hancock EW, Deal BJ, Mirvis DM, Okin P, Kligfield P, Gettes LS, et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part V: electrocardiogram changes associated with cardiac chamber hypertrophy: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology. Circulation. 2009;119(10):e251–61.

Article  PubMed  Google Scholar 

Miller DH, Eisenberg RR, Kligfield PD, Devereux RB, Casale PN, Phillips MC. Electrocardiographic recognition of left atrial enlargement. J Electrocardiol. 1983;16(1):15–22.

Article  CAS  PubMed  Google Scholar 

Romhilt DW, Bove KE, Conradi S, Scott RC. Morphologic significance of left atrial involvement. Am Heart J. 1972;83(3):322–7.

Article  CAS  PubMed  Google Scholar 

Josephson ME, Kastor JA, Morganroth J. Electrocardiographic left atrial enlargement. Electrophysiologic, echocardiographic and hemodynamic correlates. Am J Cardiol. 1977;39(7):967–71.

Article  CAS  PubMed  Google Scholar 

Lebek S, Wester M, Pec J, Poschenrieder F, Tafelmeier M, Fisser C, et al. Abnormal P-wave terminal force in lead V1 is a marker for atrial electrical dysfunction but not structural remodelling. ESC Heart Fail. 2021;8(5):4055–66.

Article  PubMed  PubMed Central  Google Scholar 

Goda T, Sugiyama Y, Ohara N, Ikegami T, Watanabe K, Kobayashi J, et al. P-Wave terminal force in lead V1 predicts paroxysmal atrial fibrillation in acute ischemic stroke. J Stroke Cerebrovasc Dis: Off J Natl Stroke Assoc. 2017;26(9):1912–5.

Article  Google Scholar 

He J, Tse G, Korantzopoulos P, Letsas KP, Ali-Hasan-Al-Saegh S, Kamel H, et al. P-Wave indices and risk of ischemic stroke: a systematic review and meta-analysis. Stroke. 2017;48(8):2066–72.

Article  PubMed  Google Scholar 

Eranti A, Aro AL, Kerola T, Anttonen O, Rissanen HA, Tikkanen JT, et al. Prevalence and prognostic significance of abnormal P terminal force in lead V1 of the ECG in the general population. Circ Arrhythm Electrophysiol. 2014;7(6):1116–21.

Article  PubMed  Google Scholar 

Masuda M, Fujita M, Iida O, Okamoto S, Ishihara T, Nanto K, et al. Left atrial low-voltage areas predict atrial fibrillation recurrence after catheter ablation in patients with paroxysmal atrial fibrillation. Int J Cardiol. 2018;257:97–101.

Liu H-T, Lee H-L, Wo H-T, Chang P-C, Wen M-S, Lin F-C, et al. P wave duration ≥ 150 ms predicts poor left atrial function and ablation outcomes in non-paroxysmal atrial fibrillation. J Electrocardiol. 2021;69:124–31.

Article  PubMed  Google Scholar 

Yamaguchi T, Tsuchiya T, Fukui A, Kawano Y, Otsubo T, Takahashi Y, et al. Impact of the extent of low-voltage zone on outcomes after voltage-based catheter ablation for persistent atrial fibrillation. J Cardiol. 2018;72(5):427–33.

Article  PubMed  Google Scholar 

Tereshchenko LG, Henrikson CA, Sotoodehnia N, Arking DE, Agarwal SK, Siscovick DS, et al. Electrocardiographic deep terminal negativity of the P wave in V(1) and risk of sudden cardiac death: the atherosclerosis risk in communities (ARIC) study. J Am Heart Assoc. 2014;3(6):e001387.

Article  PubMed  PubMed Central  Google Scholar 

Win TT, Venkatesh BA, Volpe GJ, Mewton N, Rizzi P, Sharma RK, et al. Associations of electrocardiographic P-wave characteristics with left atrial function, and diffuse left ventricular fibrosis defined by cardiac magnetic resonance: the PRIMERI study. Heart Rhythm. 2015;12(1):155–62.

Article  Google Scholar 

Holmqvist F, Husser D, Tapanainen JM, Carlson J, Jurkko R, Xia Y, et al. Interatrial conduction can be accurately determined using standard 12-lead electrocardiography: validation of P-wave morphology using electroanatomic mapping in man. Heart Rhythm. 2008;5(3):413–8.

Article  PubMed  Google Scholar 

Platonov PG, Mitrofanova LB, Chireikin LV, Olsson SB. Morphology of inter-atrial conduction routes in patients with atrial fibrillation. Europace. 2002;4(2):183–92.

Jadidi A, Müller-Edenborn B, Chen J, Keyl C, Weber R, Allgeier J, et al. The duration of the amplified sinus-P-wave identifies presence of left atrial low voltage substrate and predicts outcome after pulmonary vein isolation in patients with persistent atrial fibrillation. JACC Clin Electrophysiol. 2018;4(4):531–43.

Article  PubMed  Google Scholar 

Miyamoto K, Tsuchiya T, Narita S, Yamaguchi T, Nagamoto Y, Ando SI, et al. Bipolar electrogram amplitudes in the left atrium are related to local conduction velocity in patients with atrial fibrillation. Europace. 2009;11(12):1597–605.