Comparative efficacy of aflibercept and ranibizumab in the treatment of age-related macular degeneration with retinal pigment epithelial detachment: a systematic review and network meta-analysis

Ferris F, Fine S, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthal. 1984;102(11):1640–2.

Article  PubMed  Google Scholar 

Ambati J, Ambati B, Yoo S, Ianchulev S, Adamis A. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol. 2003;48(3):257–93.

Article  PubMed  Google Scholar 

Chappelow AV, Schachat AP. Neovascular age-related macular degeneration. Retinal Pharmacother. 2010; 128–132.

The Clinical Guideline and Clinical Pathway Development Committee of Age-Related Macular Degeneration OFDS, Chinese Ophthalmological Society, Chinese Medical Association. Pathway of clinical diagnosis and treatment of age-related macular degeneration in China. Chinese J Fundus Dis. 2013; 29(4):343–355.

Karampelas M, Malamos P, Petrou P, Georgalas I, Papaconstantinou D, Brouzas D. Retinal Pigment Epithelial Detachment in Age-Related Macular Degeneration. Ophthalmol Ther. 2020;9(4):739–56.

Article  PubMed  PubMed Central  Google Scholar 

Cheong K, Teo K, Cheung C. Influence of pigment epithelial detachment on visual acuity in neovascular age-related macular degeneration. Surv Ophthalmol. 2021;66(1):68–97.

Article  PubMed  Google Scholar 

Martin D, Maguire M, Ying G, Grunwald J, Fine S, Jaffe G. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;364(20):1897–908.

Article  CAS  PubMed  Google Scholar 

Simader C, Ritter M, Bolz M, Deák G, Mayr-Sponer U, Golbaz I, Kundi M, Schmidt-Erfurth U. Morphologic parameters relevant for visual outcome during anti-angiogenic therapy of neovascular age-related macular degeneration. Ophthalmol. 2014;121(6):1237–45.

Article  Google Scholar 

Heier J, Brown D, Chong V, Korobelnik J, Kaiser P, Nguyen Q, Kirchhof B, Ho A, Ogura Y, Yancopoulos G, et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmol. 2012;119(12):2537–48.

Article  Google Scholar 

Solomon S, Lindsley K, Vedula S, Krzystolik M, Hawkins B. Anti-vascular endothelial growth factor for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2019; 3(3):CD005139.

Selvam A, Singh S, Arora S, Patel M, Kuchhal A, Shah S, Ong J, Rasheed M, Manne S, Ibrahim M, et al. Pigment epithelial detachment composition indices (PEDCI) in neovascular age-related macular degeneration. Sci Rep. 2023;13(1):68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coscas F, Coscas G, Souied E, Tick S, Soubrane G. Optical coherence tomography identification of occult choroidal neovascularization in age-related macular degeneration. Am J Ophthalmol. 2007;144(4):592–9.

Article  PubMed  Google Scholar 

Pepple K, Mruthyunjaya P. Retinal pigment epithelial detachments in age-related macular degeneration: classification and therapeutic options. Semin Ophthalmol. 2011;26(3):198–208.

Article  PubMed  Google Scholar 

Schmidt-Erfurth U, Waldstein S, Deak G, Kundi M, Simader C. Pigment epithelial detachment followed by retinal cystoid degeneration leads to vision loss in treatment of neovascular age-related macular degeneration. Ophthalmol. 2015;122(4):822–32.

Article  Google Scholar 

Yeung L, Hsieh Y, Yang C, Chen L, Chen S, Cheng C, Sheu S, Tsai C, Wu T, Wu W, et al. Management of neovascular age-related macular degeneration: Taiwan expert consensus. J Formos Med Assoc. 2021;120(12):2061–71.

Article  PubMed  Google Scholar 

Schmidt-Erfurth U, Chong V, Loewenstein A, Larsen M, Souied E, Schlingemann R, Eldem B, Monés J, Richard G, Bandello F. Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA). Br J Ophthalmol. 2014;98(9):1144–67.

Article  PubMed  Google Scholar 

Flaxel C, Adelman R, Bailey S, Fawzi A, Lim J, Vemulakonda G, Ying G. Age-Related Macular Degeneration Preferred Practice Pattern®. Ophthalmol. 2020;127(1):P1–65.

Article  Google Scholar 

Nikkhah H, Karimi S, Ahmadieh H, Azarmina M, Abrishami M, Ahoor H, Alizadeh Y, Behboudi H, Daftarian N, Dehghan M, et al. Intravitreal Injection of Anti-vascular Endothelial Growth Factor Agents for Ocular Vascular Diseases: Clinical Practice Guideline. J Ophthalmic Vis Res. 2018;13(2):158–69.

Article  PubMed  PubMed Central  Google Scholar 

Fung A, Lalwani G, Rosenfeld P, Dubovy S, Michels S, Feuer W, Puliafito C, Davis J, Flynn H, Esquiabro M. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol. 2007;143(4):566–83.

Article  CAS  Google Scholar 

Amoaku W, Chakravarthy U, Gale R, Gavin M, Ghanchi F, Gibson J, Harding S, Johnston R, Kelly S, Lotery A, et al. Defining response to anti-VEGF therapies in neovascular AMD. Eye (Lond). 2015;29(6):721–31.

Article  CAS  PubMed  Google Scholar 

Vaze A, Nguyen V, Daien V, Arnold J, Young S, Cheung C, Lamoureux E, Bhargava M, Barthelmes D, Gillies M. RANIBIZUMAB AND AFLIBERCEPT FOR THE TREATMENT OF PIGMENT EPITHELIAL DETACHMENT IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Data from an Observational Study. Retina (Philadelphia, Pa). 2018;38(10):1954–61.

Article  CAS  PubMed  Google Scholar 

Sarraf D, London N, Khurana R, Dugel P, Gune S, Hill L, Tuomi L. Ranibizumab Treatment for Pigment Epithelial Detachment Secondary to Neovascular Age-Related Macular Degeneration: Post Hoc Analysis of the HARBOR Study. Ophthalmol. 2016;123(10):2213–24.

Article  Google Scholar 

Chan CK, Nuthi SdA, Lin SG, Abraham P, McCannel CA. Earlier therapeutic effects associated with high dose (2.0mg) Ranibizumab for treatment of vascularized pigment epithelial detachments in age-related macular degeneration. Eye. 2015;29(1):80-7.

Au A, Parikh VS, Singh RP, Ehlers JP, Yuan A, Rachitskaya AV, Sears JE, Srivastava SK, Kaiser PK, Schachat AP. Comparison of anti-VEGF therapies on fibrovascular pigment epithelial detachments in age-related macular degeneration. Br J Ophthalmol. 2016; bjophthalmol-2016–309434.

Park DH, Sun HJ, Lee SJ. A comparison of responses to intravitreal bevacizumab, ranibizumab, or aflibercept injections for neovascular age-related macular degeneration. Int Ophthalmol. 2016.

Rouvas A, Chatziralli I, Androu A, Mpougatsou P, Alonistiotis D, Douvali M, Kabanarou SA, Theodossiadis P. Ranibizumab versus aflibercept for the treatment of vascularized pigment epithelium detachment due to age-related macular degeneration. Int Ophthalmol. 2018.

Ulusoy M, Kal A, Yilmaz G. Comparison of the effects of anti-vascular endothelial growth factor treatments on pigment epithelial detachment in age-related macular degeneration. Int Ophthalmol. 2021;41(4):1363–72.

Article  PubMed  Google Scholar 

Group MPS. Subfoveal neovascular lesions in age-related macular degeneration. Guidelines for evaluation and treatment in the macular photocoagulation study. Macular Photocoagulation Study Group. Arch Ophthal. 1991; 109(9):1242–1257.

Tan A, Simhaee D, Balaratnasingam C, Dansingani K, Yannuzzi L. A Perspective on the Nature and Frequency of Pigment Epithelial Detachments. Am J Ophthalmol. 2016;172:13–27.

Article  PubMed  Google Scholar 

Gass J. Serous retinal pigment epithelial detachment with a notch. A sign of occult choroidal neovascularization. Retina (Philadelphia, Pa). 1984; 4(4):205–220.

Shu Y, Ye F, Liu H, Wei J, Sun X. Predictive value of pigment epithelial detachment markers for visual acuity outcomes in neovascular age-related macular degeneration. BMC ophthalmol. 2023;23(1):83.

Article  PubMed Central  Google Scholar 

Sarraf D, Khanani AM, Sadda SR, Chang A, Wong DT, Kempf AS, Saffar I, Tang S, Tadayoni R. Pigment epithelial detachment thickness and variability impacts visual outcomes in patients with neovascular age-related macular degeneration. Retina. 2023.

Clemens C, Alten F, Termühlen J, Mihailovic N, Rosenberger F, Heiduschka P, Eter N. Prospective PED-study of intravitreal aflibercept for refractory vascularized pigment epithelium detachment due to age-related macular degeneration: morphologic characteristics of non-responders in optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2020;258(7):1411–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarwar S, Bakbak B, Sadiq MA, Sepah YJ, Shah SM, Ibrahim M, Do DV, Quan DN. Fusion Proteins: Aflibercept (VEGF Trap-Eye). Dev Ophthalmol. 2016;55:282.

Article  PubMed  Google Scholar 

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