Report AsA: 2020 Alzheimer’s disease facts and figures. Alzheimers Dementia 2020.

Xu J, Patassini S, Rustogi N, Riba-Garcia I, Hale BD, Phillips AM, Waldvogel H, Haines R, Bradbury P, Stevens A, et al. Regional protein expression in human Alzheimer’s brain correlates with disease severity. Commun Biol. 2019;2:43.

Article  PubMed  PubMed Central  Google Scholar 

Swarbrick S, Wragg N, Ghosh S, Stolzing A. Systematic review of miRNA as biomarkers in Alzheimer’s disease. Mol Neurobiol. 2019;56:6156–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thal DR, Rub U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology. 2002;58:1791–800.

Article  PubMed  Google Scholar 

Braak H, Braak E, Bohl J, Lang W. Alzheimer’s disease: amyloid plaques in the cerebellum. J Neurol Sci. 1989;93:277–87.

Article  CAS  PubMed  Google Scholar 

Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82:239–59.

Article  CAS  PubMed  Google Scholar 

Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jaggi F, Wolburg H, Gengler S, et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep. 2006;7:940–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daini E, Secco V, Liao W, Zoli M, Vilella A. A regional and cellular analysis of the early intracellular and extracellular accumulation of Abeta in the brain of 5XFAD mice. Neurosci Lett. 2021;754: 135869.

Article  CAS  PubMed  Google Scholar 

Chaudhari K, Wang L, Kruse J, Winters A, Sumien N, Shetty R, Prah J, Liu R, Shi J, Forster M, Yang SH. Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer’s disease. Neurol Res. 2021;43:570–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med. 2016;8:595–608.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sepulveda-Falla D, Barrera-Ocampo A, Hagel C, Korwitz A, Vinueza-Veloz MF, Zhou K, Schonewille M, Zhou H, Velazquez-Perez L, Rodriguez-Labrada R, et al. Familial Alzheimer’s disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. J Clin Invest. 2014;124:1552–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogomori K, Kitamoto T, Tateishi J, Sato Y, Suetsugu M, Abe M. Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer’s disease. Am J Pathol. 1989;134:243–51.

CAS  PubMed  PubMed Central  Google Scholar 

Joachim CL, Morris JH, Selkoe DJ. Diffuse senile plaques occur commonly in the cerebellum in Alzheimer’s disease. Am J Pathol. 1989;135:309–19.

CAS  PubMed  PubMed Central  Google Scholar 

Jacobs HIL, Hopkins DA, Mayrhofer HC, Bruner E, van Leeuwen FW, Raaijmakers W, Schmahmann JD. The cerebellum in Alzheimer’s disease: evaluating its role in cognitive decline. Brain. 2018;141:37–47.

Article  PubMed  Google Scholar 

Knesaurek K, Warnock G, Kostakoglu L, Burger C, for Alzheimer’s Disease Neouroimaging I. Comparison of standardized uptake value ratio calculations in amyloid positron emission tomography brain imaging. World J Nucl Med. 2018;17:21–6.

Article  PubMed  PubMed Central  Google Scholar 

Grothe MJ, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel SJ, Alzheimer’s Disease Neuroimaging I. In vivo staging of regional amyloid deposition. Neurology. 2017;89:2031–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsubaki Y, Akamatsu G, Shimokawa N, Katsube S, Takashima A, Sasaki M, Japanese Alzheimer’s Disease Neuroimaging I. Development and evaluation of an automated quantification tool for amyloid PET images. EJNMMI Phys. 2020;7:59.

Article  PubMed  PubMed Central  Google Scholar 

Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC. Single App knock-in mouse models of Alzheimer’s disease. Nat Neurosci. 2014;17:661–3.

Article  CAS  PubMed  Google Scholar 

Sasaguri H, Hashimoto S, Watamura N, Sato K, Takamura R, Nagata K, Tsubuki S, Ohshima T, Yoshiki A, Sato K, et al. Recent advances in the modeling of Alzheimer’s disease. Front Neurosci. 2022;16: 807473.

Article  PubMed  PubMed Central  Google Scholar 

Massimi L, Pieroni N, Maugeri L, Fratini M, Brun F, Bukreeva I, Santamaria G, Medici V, Poloni TE, Balducci C, Cedola A. Assessment of plaque morphology in Alzheimer’s mouse cerebellum using three-dimensional X-ray phase-based virtual histology. Sci Rep. 2020;10:11233.

Article  PubMed  PubMed Central  Google Scholar 

Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Nakazato Y. Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by beta protein immunostain. Acta Neuropathol. 1989;77:314–9.

Article  CAS  PubMed  Google Scholar 

Low AYT, Goldstein N, Gaunt JR, Huang KP, Zainolabidin N, Yip AKK, Carty JRE, Choi JY, Miller AM, Ho HST, et al. Reverse-translational identification of a cerebellar satiation network. Nature. 2021;600:269–73.

Article  CAS  PubMed  Google Scholar 

Bakken TE, Hodge RD, Miller JA, Yao Z, Nguyen TN, Aevermann B, Barkan E, Bertagnolli D, Casper T, Dee N, et al. Single-nucleus and single-cell transcriptomes compared in matched cortical cell types. PLoS ONE. 2018;13: e0209648.

Article  PubMed  PubMed Central  Google Scholar 

Zeisel A, Hochgerner H, Lonnerberg P, Johnsson A, Memic F, van der Zwan J, Haring M, Braun E, Borm LE, La Manno G, et al. Molecular Architecture of the mouse nervous system. Cell. 2018;174(999–1014): e1022.

Google Scholar 

Pandey S, Shen K, Lee SH, Shen YA, Wang Y, Otero-Garcia M, Kotova N, Vito ST, Laufer BI, Newton DF, et al. Disease-associated oligodendrocyte responses across neurodegenerative diseases. Cell Rep. 2022;40: 111189.

Article  CAS  PubMed  Google Scholar 

Arranz AM, De Strooper B. The role of astroglia in Alzheimer’s disease: pathophysiology and clinical implications. Lancet Neurol. 2019;18:406–14.

Article  CAS  PubMed  Google Scholar 

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Munch AE, Chung WS, Peterson TC, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bandyopadhyay S. Role of neuron and glia in Alzheimer’s disease and associated vascular dysfunction. Front Aging Neurosci. 2021;13: 653334.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, David E, Baruch K, Lara-Astaiso D, Toth B, et al. A unique microglia type associated with restricting development of Alzheimer’s disease. Cell. 2017;169(1276–1290): e1217.

Google Scholar 

Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, et al. The major risk factors for Alzheimer’s disease: age, sex, and genes modulate the microglia response to abeta plaques. Cell Rep. 2019;27(1293–1306): e1296.

Google Scholar 

Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, et al. Single-cell transcriptomic analysis of Alzheimer’s disease. Nature. 2019;570:332–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Friedman BA, Srinivasan K, Ayalon G, Meilandt WJ, Lin H, Huntley MA, Cao Y, Lee SH, Haddick PCG, Ngu H, et al. Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer’s disease not evident in mouse models. Cell Rep. 2018;22:832–47.

Article  CAS  PubMed  Google Scholar 

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O’Loughlin E, Xu Y, Fanek Z, et al. The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases. Immunity. 2017;47(566–581): e569.

Google Scholar 

Habib N, McCabe C, Medina S, Varshavsky M, Kitsberg D, Dvir-Szternfeld R, Green G, Dionne D, Nguyen L, Marshall JL, et al. Disease-associated astrocytes in Alzheimer’s disease and aging. Nat Neurosci. 2020;23:701–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee S, Kim TK, Choi JE, Kim HS, Im HI. Striatal ZBTB16 is associated with cognitive deficits in Alzheimer disease mice. Int Neurourol J. 2022;26:S106-116.

Article  PubMed  PubMed Central  Google Scholar 

Pratap AA, Holsinger RMD. Altered brain leptin and leptin receptor expression in the 5XFAD mouse model of Alzheimer’s disease. Pharmaceuticals. 2020;13:401.

Article  CAS  PubMed  PubMed Central  Google Scholar