Fang C, Lau WL, Sun J, Chang R, Vallejo A, Lee D, et al. Chronic kidney disease promotes cerebral microhemorrhage formation. J Neuroinflammation. 2023;20:51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fisher M, French S, Ji P, Kim RC. Cerebral microbleeds in the elderly: a pathological analysis. Stroke. 2010;41:2782–5.

Article  PubMed  PubMed Central  Google Scholar 

Fisher MJ. Brain regulation of thrombosis and hemostasis: from theory to practice. Stroke. 2013;44:3275–85.

Article  PubMed  PubMed Central  Google Scholar 

Zerna C, Modi J, Bilston L, Shoamanesh A, Coutts SB, Smith EE. Cerebral microbleeds and cortical superficial siderosis in patients presenting with minor cerebrovascular events. Stroke. 2016;47:2236–41.

Article  PubMed  Google Scholar 

Caunca MR, Del Brutto V, Gardener H, Shah N, Dequatre-Ponchelle N, Cheung YK, et al. Cerebral microbleeds, vascular risk factors, and magnetic resonance imaging markers: the northern Manhattan study. J Am Heart Assoc. 2016;5: e003477.

Article  PubMed  PubMed Central  Google Scholar 

Poels MM, Vernooij MW, Ikram MA, Hofman A, Krestin GP, van der Lugt A, et al. Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study. Stroke. 2010;41:S103–6.

Article  PubMed  Google Scholar 

Altmann-Schneider I, Trompet S, de Craen AJ, van Es AC, Jukema JW, Stott DJ, et al. Cerebral microbleeds are predictive of mortality in the elderly. Stroke. 2011;42:638–44.

Article  PubMed  Google Scholar 

Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol. 2009;8:165–74.

Article  PubMed  PubMed Central  Google Scholar 

Vazquez-Justes D, Aguirregoicoa I, Fernandez L, Carnes-Vendrell A, Dakterzada F, Sanjuan L, et al. Clinical impact of microbleeds in patients with Alzheimer’s disease. BMC Geriatr. 2022;22:774.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wadi LC, Grigoryan MM, Kim RC, Fang C, Kim J, Corrada MM, et al. Mechanisms of cerebral microbleeds. J Neuropathol Exp Neurol. 2020;42:1093–9.

PubMed  Google Scholar 

Fisher M. Cerebral microbleeds: where are we now? Neurology. 2014;83:1304–5.

Article  PubMed  Google Scholar 

Pan P, Xu L, Zhang H, Liu Y, Lu X, Chen G, et al. A review of hematoma components clearance mechanism after subarachnoid hemorrhage. Front Neurosci. 2020;14:685.

Article  PubMed  PubMed Central  Google Scholar 

Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, et al. Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds. Neuropathol Appl Neurobiol. 2014;40:258–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang R, Castillo J, Zambon AC, Krasieva TB, Fisher MJ, Sumbria RK. Brain endothelial erythrophagocytosis and hemoglobin transmigration across brain endothelium: implications for pathogenesis of cerebral microbleeds. Front Cell Neurosci. 2018;12:279.

Article  PubMed  PubMed Central  Google Scholar 

Sun J, Vyas P, Mann S, Paganini-Hill A, Nunes ACF, Lau WL, et al. Insights into the mechanisms of brain endothelial erythrophagocytosis. Front Cell Dev Biol. 2021;9: 672009.

Article  PubMed  PubMed Central  Google Scholar 

Fens MH, van Wijk R, Andringa G, van Rooijen KL, Dijstelbloem HM, Rasmussen JT, et al. A role for activated endothelial cells in red blood cell clearance: implications for vasopathology. Haematologica. 2012;97:500–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, et al. Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation. Sci Transl Med. 2014;6:226ra31.

Article  PubMed  Google Scholar 

van der Wijk AE, Georgakopoulou T, Majolee J, van Bezu JSM, van der Stoel MM, van Het Hof BJ, et al. Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain. Acta Neuropathol Commun. 2020;8:195.

Article  PubMed  PubMed Central  Google Scholar 

Sun J, Ou W, Han D, Paganini-Hill A, Fisher MJ, Sumbria RK. Comparative studies between the murine immortalized brain endothelial cell line (bEnd.3) and induced pluripotent stem cell-derived human brain endothelial cells for paracellular transport. PLoS ONE. 2022;17:e0268860.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hierso R, Waltz X, Mora P, Romana M, Lemonne N, Connes P, et al. Effects of oxidative stress on red blood cell rheology in sickle cell patients. Br J Haematol. 2014;166:601–6.

Article  CAS  PubMed  Google Scholar 

Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, et al. Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. Am J Pathol. 2007;170:967–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hannemann A, Rees DC, Brewin JN, Noe A, Low B, Gibson JS. Oxidative stress and phosphatidylserine exposure in red cells from patients with sickle cell anaemia. Br J Haematol. 2018;182:567–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turpin C, Meilhac O, Bourdon E, Canonne-Hergaux F, Rondeau P. Methodologies and tools to shed light on erythrophagocytosis. Biochimie. 2022;202:166–79.

Article  CAS  PubMed  Google Scholar 

Healey G, Veale MF, Sparrow RLA. fluorometric quantitative erythrophagocytosis assay using human THP-1 monocytic cells and PKH26-labelled red blood cells. J Immunol Methods. 2007;322:50–6.

Article  CAS  PubMed  Google Scholar 

Chang R, Sumbria RK. Quantitative evaluation of cerebral microhemorrhages in the mouse brain. Methods Mol Biol. 2023;2616:181–90.

Article  CAS  PubMed  Google Scholar 

Grieco SF, Qiao X, Zheng X, Liu Y, Chen L, Zhang H, et al. Subanesthetic ketamine reactivates adult cortical plasticity to restore vision from amblyopia. Curr Biol. 2020;30(3591–3603): e8.

Google Scholar 

Yu Z, Guindani M, Grieco SF, Chen L, Holmes TC, Xu X. Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research. Neuron. 2022;110:21–35.

Article  CAS  PubMed  Google Scholar 

Jurga AM, Paleczna M, Kuter KZ. Overview of general and discriminating markers of differential microglia phenotypes. Front Cell Neurosci. 2020;14:198.

Article  PubMed  PubMed Central  Google Scholar 

Gottlieb Y, Topaz O, Cohen LA, Yakov LD, Haber T, Morgenstern A, et al. Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro. Haematologica. 2012;97:994–1002.

Article  PubMed  PubMed Central  Google Scholar 

Kiefer CR, Snyder LM. Oxidation and erythrocyte senescence. Curr Opin Hematol. 2000;7:113–6.

Article  CAS  PubMed  Google Scholar 

Lizarralde-Iragorri MA, Lefevre SD, Cochet S, El Hoss S, Brousse V, Filipe A, et al. Oxidative stress activates red cell adhesion to laminin in sickle cell disease. Haematologica. 2021;106:2478–88.

Article  CAS  PubMed  Google Scholar 

Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J. Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Nature. 2010;465:478–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adams Y, Olsen RW, Bengtsson A, Dalgaard N, Zdioruk M, Satpathi S, et al. Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood-brain barrier in cerebral malaria. J Exp Med. 2021;218: e20201266.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Catan A, Turpin C, Diotel N, Patche J, Guerin-Dubourg A, Debussche X, et al. Aging and glycation promote erythrocyte phagocytosis by human endothelial cells: potential impact in atherothrombosis under diabetic conditions. Atherosclerosis. 2019;291:87–98.

Article  CAS  PubMed  Google Scholar 

Erdener SE, Tang J, Sajjadi A, Kilic K, Kura S, Schaffer CB, et al. Spatio-temporal dynamics of cerebral capillary segments with stalling red blood cells. J Cereb Blood Flow Metab. 2019;39:886–900.

Article  PubMed  Google Scholar 

Chang R, Al Maghribi A, Vanderpoel V, Vasilevko V, Cribbs DH, Boado R, et al. Brain penetrating bifunctional erythropoietin-transferrin receptor antibody fusion protein for Alzheimer’s disease. Mol Pharm. 2018;15:4963–73.

Article  CAS