Research progress on the mechanism of traditional Chinese medicine regulating intestinal microbiota to combat influenza a virus infection

Gaitonde DY, Moore FC, Morgan MK. Influenza: diagnosis and treatment. Am Family Phys. 2019;100(12):751–8.

Google Scholar 

Michaelis M, Doerr HW, Cinatl J. Jr. An Influenza A H1N1 virus revival - pandemic H1N1/09 virus. Infection. 2009;37(5):381–9.

Article  CAS  PubMed  Google Scholar 

Ghebrehewet S, MacPherson P, Ho A, Influenza. BMJ (Clinical Research ed). 2016;355:i6258.

PubMed  Google Scholar 

Paules CI, Sullivan SG, Subbarao K, Fauci AS. Chasing Seasonal Influenza - The need for a Universal Influenza Vaccine. N Engl J Med. 2018;378(1):7–9.

Article  PubMed  Google Scholar 

Wang X, Li Y, O’Brien KL, Madhi SA, Widdowson MA, Byass P, et al. Global burden of Respiratory Infections associated with seasonal Influenza in children under 5 years in 2018: a systematic review and modelling study. The Lancet Global Health. 2020;8(4):e497–e510.

Article  PubMed  PubMed Central  Google Scholar 

Takamatsu K, Marumo S, Fukui M, Hata A. Safety and efficacy of anti-influenza Drugs, intravenous peramivir against Influenza virus Infection in elderly patients with underlying Disease. Journal of microbiology, immunology, and Infection = Wei Mian Yu Gan ran Za Zhi. 2017;50(4):541–4.

Dunning J, Baillie JK, Cao B, Hayden FG. Antiviral combinations for severe Influenza. Lancet Infect Dis. 2014;14(12):1259–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ludwig S, Zell R, Schwemmle M, Herold S. Influenza, a One Health paradigm–novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential. Int J Med Microbiology: IJMM. 2014;304(7):894–901.

Article  Google Scholar 

Ono H, Okamura M, Fukushima A. [Similarity of clinically significant neuropsychiatric adverse reactions listed in Package inserts between the anti-influenza Drugs Oseltamivir and Amantadine (Possibility Attributable to Common Pharmacological effects)]. Yakugaku Zasshi. J Pharm Soc Japan. 2018;138(9):1201–15.

Article  CAS  Google Scholar 

Wu X, Wu X, Sun Q, Zhang C, Yang S, Li L, et al. Progress of small molecular inhibitors in the development of anti-influenza virus agents. Theranostics. 2017;7(4):826–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, et al. Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 2008;133(2):235–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu S, Chen Y, Wu Z, Chen Y, Gao H, Lv L, et al. Alterations of the gut microbiota in patients with Coronavirus Disease 2019 or H1N1 Influenza. Clin Infect Diseases: Official Publication Infect Dis Soc Am. 2020;71(10):2669–78.

Article  CAS  Google Scholar 

Lv L, Gu S, Jiang H, Yan R, Chen Y, Chen Y, et al. Gut mycobiota alterations in patients with COVID-19 and H1N1 Infections and their associations with clinical features. Commun Biology. 2021;4(1):480.

Article  CAS  Google Scholar 

Xi S, Li Y, Yue L, Gong Y, Qian L, Liang T, et al. Role of traditional Chinese medicine in the management of viral Pneumonia. Front Pharmacol. 2020;11:582322.

Article  CAS  PubMed  PubMed Central  Google Scholar 

JIN Y-H CAIL, Zhen-ShunCHENG CHENGH, DENG T, FAN Y-P, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected Pneumonia(full version). Med J Chin People’s Liberation Army | Med J Chin PLA. 2020;45(01):1–20.

Google Scholar 

Tao W, Li-feng H, Yue-fei W, Lin M, Jian Y, Jun-hua Z, et al. Recent advances in treatment of viral Pneumonia using Chinese patent medicine. China J Chin Materia Med. 2020;45(07):1509–14.

Google Scholar 

Feng W, Ao H, Peng C, Yan D. Gut microbiota, a new frontier to understand traditional Chinese medicines. Pharmacol Res. 2019;142:176–91.

Article  CAS  PubMed  Google Scholar 

Xu J, Chen HB, Li SL. Understanding the Molecular mechanisms of the interplay between Herbal Medicines and Gut Microbiota. Med Res Rev. 2017;37(5):1140–85.

Article  PubMed  Google Scholar 

Liu JX, Yuan HY, Li YN, Wei Z, Liu Y, Liang J. Ephedra sinica polysaccharide alleviates airway inflammations of mouse asthma-like induced by PM2.5 and ovalbumin via the regulation of gut microbiota and short chain fatty acid. J Pharm Pharmacol. 2022;74(12):1784–96.

Article  PubMed  Google Scholar 

Chen Z, Zhang Z, Liu J, Qi H, Li J, Chen J, et al. Gut microbiota: therapeutic targets of Ginseng against multiple disorders and Ginsenoside Transformation. Front Cell Infect Microbiol. 2022;12:853981.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang YJ, Li S, Gan RY, Zhou T, Xu DP, Li HB. Impacts of gut bacteria on human health and Diseases. Int J Mol Sci. 2015;16(4):7493–519.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Donaldson GP, Lee SM, Mazmanian SK. Gut biogeography of the bacterial microbiota. Nat Rev Microbiol. 2016;14(1):20–32.

Article  CAS  PubMed  Google Scholar 

Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci USA. 2008;105(6):2117–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heiss CN, Olofsson LE. The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system. J Neuroendocrinol. 2019;31(5):e12684.

Article  PubMed  Google Scholar 

Dang AT, Marsland BJ. Microbes, metabolites, and the gut-lung axis. Mucosal Immunol. 2019;12(4):843–50.

Article  CAS  PubMed  Google Scholar 

Espírito Santo C, Caseiro C, Martins MJ, Monteiro R, Brandão I. Gut microbiota, in the halfway between Nutrition and lung function. Nutrients. 2021;13(5).

Bradley CP, Teng F, Felix KM, Sano T, Naskar D, Block KE, et al. Segmented filamentous Bacteria provoke lung autoimmunity by Inducing Gut-Lung Axis Th17 cells expressing dual TCRs. Cell Host Microbe. 2017;22(5):697–704e4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dumas A, Bernard L, Poquet Y, Lugo-Villarino G, Neyrolles O. The role of the lung microbiota and the gut-lung axis in respiratory infectious Diseases. Cell Microbiol. 2018;20(12):e12966.

Article  PubMed  Google Scholar 

Enaud R, Prevel R, Ciarlo E, Beaufils F, Wieërs G, Guery B, et al. The gut-lung Axis in Health and Respiratory Diseases: a place for inter-organ and Inter-kingdom Crosstalks. Front Cell Infect Microbiol. 2020;10:9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu B, Yu Y, Zhao M, Xiao K, Yan P, Duan Z, et al. Correlation analysis of the Microbiome and Immune function in the Lung-Gut Axis of critically Ill patients in the ICU. Front Med. 2022;9:808302.

Article  Google Scholar 

Gauguet S, D’Ortona S, Ahnger-Pier K, Duan B, Surana NK, Lu R, et al. Intestinal microbiota of mice influences resistance to Staphylococcus aureus Pneumonia. Infect Immun. 2015;83(10):4003–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Groves HT, Cuthbertson L, James P, Moffatt MF, Cox MJ, Tregoning JS. Respiratory Disease following viral lung Infection alters the murine gut microbiota. Front Immunol. 2018;9:182.

Article  PubMed  PubMed Central  Google Scholar 

Deriu E, Boxx GM, He X, Pan C, Benavidez SD, Cen L, et al. Influenza virus affects intestinal microbiota and Secondary Salmonella Infection in the gut through type I interferons. PLoS Pathog. 2016;12(5):e1005572.

Article  PubMed  PubMed Central  Google Scholar 

Gierse LC, Meene A, Schultz D, Schwaiger T, Schröder C, Mücke P, et al. Influenza a H1N1 Induced Disturbance of the respiratory and fecal microbiome of German Landrace pigs - a Multi-omics characterization. Microbiol Spectr. 2021;9(2):e0018221.

Article  PubMed  Google Scholar 

Schuijt TJ, Lankelma JM, Scicluna BP, de Sousa e Melo F, Roelofs JJ, de Boer JD, et al. The gut microbiota plays a protective role in the host defence against pneumococcal Pneumonia. Gut. 2016;65(4):575–83.

Article  CAS  PubMed  Google Scholar 

Bartley JM, Zhou X, Kuchel GA, Weinstock GM, Haynes L. Impact of Age, caloric restriction, and Influenza Infection on mouse gut microbiome: an exploratory study of the role of age-related Microbiome changes on Influenza responses. Front Immunol. 2017;8:1164.

Article  PubMed  PubMed Central  Google Scholar 

Yildiz S, Mazel-Sanchez B, Kandasamy M, Manicassamy B, Schmolke M. Influenza A virus Infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis. Microbiome. 2018;6(1):9.

Article  PubMed  PubMed Central  Google Scholar 

Sencio V, Barthelemy A, Tavares LP, Machado MG, Soulard D, Cuinat C, et al. Gut dysbiosis during Influenza contributes to pulmonary pneumococcal superinfection through altered short-chain fatty acid production. Cell Rep. 2020;30(9):2934–47e6.

Article  CAS  PubMed  Google Scholar 

Zhang FX, Li ZT, Yang X, Xie ZN, Chen MH, Yao ZH, et al. Discovery of anti-flu substances and mechanism of Shuang-Huang-Lian water extract based on serum pharmaco-chemistry and network pharmacology. J Ethnopharmacol. 2021;268:113660.

Article  CAS  PubMed 

Comments (0)

No login
gif