Altmeyer A, Josset E, Denis JM, Gueulette J, Slabbert J, Mutter D, Noel G, Bischoff P (2012) The mTOR inhibitor RAD001 augments radiation-induced growth inhibition in a hepatocellular carcinoma cell line by increasing autophagy. Int J Oncol 41:1381–1386
Article CAS PubMed Google Scholar
Ariaans G, Jalving M, Vries EG, Jong S (2017) Anti-tumor effects of everolimus and metformin are complementary and glucose-dependent in breast cancer cells. BMC Cancer 17:232
Article PubMed PubMed Central Google Scholar
Avniel-Polak S, Leibowitz G, Doviner V, Gross DJ, Grozinsky-Glasberg S (2018) Combining chloroquine with RAD001 inhibits tumor growth in a NEN mouse model. Endocr Relat Cancer 25:677–686
Article CAS PubMed Google Scholar
Bedke J, Gauler T, Grunwald V, Hegele A, Herrmann E, Hinz S, Janssen J, Schmitz S, Schostak M, Tesch H, Zastrow S, Miller K (2017) Systemic therapy in metastatic renal cell carcinoma. World J Urol 35:179–188
Article CAS PubMed Google Scholar
Bhat S (2010) Role of surgery in advanced/metastatic renal cell carcinoma. Indian J Urol 26:167–176
Article PubMed PubMed Central Google Scholar
Calderwood SK (2013) Tumor heterogeneity, clonal evolution, and therapy resistance: an opportunity for multitargeting therapy. Discov Med 15:188–194
PubMed PubMed Central Google Scholar
Chao A, Lin CY, Wu RC, Lee YS, Lee LY, Tsai CL, Yang LY, Liu H, Chen SJ, Wang TH, Lai CH (2018) The combination of everolimus and terameprocol exerts synergistic antiproliferative effects in endometrial cancer: molecular role of insulin-like growth factor binding protein 2. J Mol Med (berl) 96:1251–1266
Article CAS PubMed Google Scholar
FDA approves drug combo for kidney cancer (2016) Cancer Discov 6:687–688
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386
Article CAS PubMed Google Scholar
Fisher R, Gore M, Larkin J (2013) Current and future systemic treatments for renal cell carcinoma. Semin Cancer Biol 23:38–45
Francois RA, Maeng K, Nawab A, Kaye FJ, Hochwald SN, Zajac-Kaye M (2015) Targeting focal adhesion kinase and resistance to mTOR inhibition in pancreatic neuroendocrine tumors. J Natl Cancer Inst 107(8):djv123. https://doi.org/10.1093/jnci/djv123
Gottlieb DJ, Hek K, Chen TH, Watson NF, Eiriksdottir G, Byrne EM, Cornelis M, Warby SC, Bandinelli S, Cherkas L, Evans DS, Grabe HJ, Lahti J, Li M, Lehtimäki T, Lumley T, Marciante KD, Pérusse L, Psaty BM, Robbins J, Tiemeier H (2015) Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Molecular psychiatry 20(10):1232–1239. https://doi.org/10.1038/mp.2014.133
Article CAS PubMed Google Scholar
Huang JJ, Li ZM, Huang Y, Tian Y, He XX, Xiao J, Lin TY (2012) Schedule-dependent inhibition of T-cell lymphoma cells by cotreatment with the mTOR inhibitor everolimus and anticancer drugs. Invest New Drugs 30:223–235
Article CAS PubMed Google Scholar
Hurvitz SA, Kalous O, Conklin D, Desai AJ, Dering J, Anderson L, O’Brien NA, Kolarova T, Finn RS, Linnartz R, Chen D, Slamon DJ (2015) In vitro activity of the mTOR inhibitor everolimus, in a large panel of breast cancer cell lines and analysis for predictors of response. Breast Cancer Res Treat 149:669–680
Article CAS PubMed Google Scholar
Karam JA, Zhang XY, Tamboli P, Margulis V, Wang H, Abel EJ, Culp SH, Wood CG (2011) Development and characterization of clinically relevant tumor models from patients with renal cell carcinoma. Eur Urol 59:619–628
Liu GY, Sabatini DM (2020) Author correction: mTOR at the nexus of nutrition, growth, ageing and disease. Nat Rev Mol Cell Biol 21:246
Lui A, New J, Ogony J, Thomas S, Lewis-Wambi J (2016) Everolimus downregulates estrogen receptor and induces autophagy in aromatase inhibitor-resistant breast cancer cells. BMC Cancer 16:487
Article PubMed PubMed Central Google Scholar
Saran U, Foti M, Dufour JF (2015) Cellular and molecular effects of the mTOR inhibitor everolimus. Clin Sci (lond) 129:895–914
Article CAS PubMed Google Scholar
Sharma R, Kadife E, Myers M, Kannourakis G, Prithviraj P, Ahmed N (2021) Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma. J Exp Clin Cancer Res 40:186
Article PubMed PubMed Central Google Scholar
Wang Y, Yuan X, Li J, Liu Z, Li X, Wang Z, Wei L, Li Y, Wang X (2021) The Synergistic Effects of SHR6390 Combined With Pyrotinib on HER2+/HR+ Breast Cancer. Frontiers in cell and developmental biology 9. https://doi.org/10.3389/fcell.2021.785796
Wedel S, Hudak L, Seibel JM, Juengel E, Tsaur I, Wiesner C, Haferkamp A, Blaheta RA (2011) Inhibitory effects of the HDAC inhibitor valproic acid on prostate cancer growth are enhanced by simultaneous application of the mTOR inhibitor RAD001. Life Sci 88:418–424
Article CAS PubMed Google Scholar
Zhang Q, Zhang Y, Chen Y, Qian J, Zhang X, Yu K (2019) A novel mTORC1/2 inhibitor (MTI-31) inhibits tumor growth, epithelial-mesenchymal transition, metastases, and improves antitumor immunity in preclinical models of lung cancer. Clin Cancer Res 25:3630–3642
Article CAS PubMed Google Scholar
Zhang R, Chen X, Miao C, Chen Y, Li Y, Shen J, Yuan M, Chen M, Cheng J, Liu S, Sun Q, Wu J (2024) Tumor-associated macrophage-derived exosomal miR-513b-5p is a target of jianpi yangzheng decoction for inhibiting gastric cancer. Journal of ethnopharmacology 318(Pt B). https://doi.org/10.1016/j.jep.2023.117013
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