Authors DOI: https://doi.org/10.5489/cuaj.8342 Keywords: Female; Bladder outlet obstruction; Urethral pressure profile; Urodynamics; Urethrolysis Abstract

INTRODUCTION: Long-term urodynamic (UDS) and urethral pressure profilometry (UPP) parameters in women with voiding phase dysfunction following an anti-incontinence (AI) procedure have been poorly characterized. We report our 10-year UDS findings in women with voiding phase dysfunction after AI procedure, who underwent urethrolysis.

METHODS: We identified sequential records containing urethrolysis current procedural terminology codes over a 10-year period. Records of women with preoperative UDS were reviewed for demographics, UDS tracing, and outcomes following urethrolysis.

RESULTS: Twenty-five women (mean age 60 years) had voiding phase dysfunction and underwent urethrolysis at a mean of 47 months (interquartile range [IQR] 12–61) after AI procedure. Preoperatively, six (24%) women required intermittent catheterization. Free uroflowmetry revealed a mean maximum peak flow (Qmax) of 9.6 ml/s (IQR 7.0–11.0), voided volume of 137 ml (IQR 81–169), and postvoid residual of 167 ml (IQR 43–288). UDS revealed a mean UPP length of 24 mm (IQR 20–27), UPP closure pressure of 78 cmH2O (IQR 59–103), detrusor pressure at maximum flow (Pdet@Qmax) of 31 cmH2O (IQR 19–43), Qmax of 7.9 ml/s (IQR 5.0–12.0), bladder outlet obstruction index of 15 (IQR 0–34), and bladder contractility index of 71 (IQR 60–81). UPP length was significantly associated (Pearson correlation, p<0.05) with bladder outlet obstruction index (r=0.80), Pdet@Qmax (r=0.75), and time since AI procedure (r=-0.70). UPP closure pressure was significantly associated with age (r=-0.64), volume of first (r=-0.64) and strong (r=-0.78) desire, and capacity (r=-0.71). Following urethrolysis, spontaneous voiding was achieved in 23 (92%) women at followup (mean 308 days).

CONCLUSIONS: UPP may help characterize outlet parameters in women with voiding phase dysfunction following an AI procedure, who ultimately undergo urethrolysis.

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How to Cite

Dobberfuhl, A. D., Comiter, C. V., & Deb, S. (2023). Urodynamic and urethral pressure profilometry findings in women with voiding phase dysfunction treated with surgical urethrolysis. Canadian Urological Association Journal, 17(11), 374–80. https://doi.org/10.5489/cuaj.8342

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